Association between lesion location and symptoms of restless leg syndrome (RLS) among patients with multiple sclerosis (MS)

Hunter SF (2016) Overview and diagnosis of multiple sclerosis. Am J Manag Care 22(6 Suppl):s141–s150

PubMed  Google Scholar 

AlJumah M, Bunyan R, Al Otaibi H et al (2020) Rising prevalence of multiple sclerosis in Saudi Arabia: a descriptive study. BMC Neurol 20(1):49

Article  PubMed  PubMed Central  Google Scholar 

Bebo B, Cintina I, LaRocca N et al (2022) The economic burden of multiple sclerosis in the United States: estimate of direct and indirect costs. Neurology 98(18):e1810–e1817

Article  PubMed  PubMed Central  Google Scholar 

Lublin FD, Reingold SC, Cohen JA et al (2014) Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology 83(3):278–286

Article  PubMed  PubMed Central  Google Scholar 

White CP, White MB, Russell CS (2008) Invisible and visible symptoms of multiple sclerosis: which are more predictive of health distress? J Neurosci Nurs 40(2):85–95

Article  PubMed  Google Scholar 

Stanton BR, Barnes F, Silber E (2006) Sleep and fatigue in multiple sclerosis. Mult Scler 12(4):481–486

Article  CAS  PubMed  Google Scholar 

Tachibana N, Howard RS, Hirsch NP et al (1994) Sleep problems in multiple sclerosis. Eur Neurol 34(6):320–323

Article  CAS  PubMed  Google Scholar 

Fleming WE, Pollak CP (2005) Sleep disorders in multiple sclerosis. Semin Neurol 25(1):64–68

Article  PubMed  Google Scholar 

Bamer A, Johnson K, Amtmann D et al (2008) Prevalence of sleep problems in individuals with multiple sclerosis. Mult Scler 14(8):1127–1130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Veauthier C, Gaede G, Radbruch H et al (2015) Sleep disorders reduce health-related quality of life in multiple sclerosis. Int J Mol Sci 16(7):16514–16528

Article  PubMed  PubMed Central  Google Scholar 

Trotti LM, Rye DB (2011) Restless legs syndrome. Handb Clin Neurol 99:661–673

Google Scholar 

Wali S, Abaalkhail B (2015) Prevalence of restless legs syndrome and associated risk factors among middle-aged Saudi population. Ann Thorac Med 10(3):193

Article  PubMed  PubMed Central  Google Scholar 

Aljarallah S, Alkhawajah N, Aldosari O et al (2023) Restless leg syndrome in multiple sclerosis: a case-control study. Front Neurol 14:1194212

Article  PubMed  PubMed Central  Google Scholar 

Ning P, Hu F, Yang B et al (2018) Systematic review and meta-analysis of observational studies to understand the prevalence of restless legs syndrome in multiple sclerosis: an update. Sleep Med 50:97–104

Article  PubMed  Google Scholar 

Bruno E, Nicoletti A, Messina S et al (2015) Restless legs syndrome and multiple sclerosis: a population based case-control study in Catania. Sicily. Eur J Neurol 22(6):1018–1021

Article  CAS  PubMed  Google Scholar 

Guo S, Huang J, Jiang H et al (2017) Restless legs syndrome: from pathophysiology to clinical diagnosis and management. Front Aging Neurosci 9:171

Article  PubMed  PubMed Central  Google Scholar 

Ward RJ, Zucca FA, Duyn JH et al (2014) The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol 13(10):1045–1060

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Borreguero D, Williams AM (2014) An update on restless legs syndrome (Willis-Ekbom disease): clinical features, pathogenesis and treatment. Curr Opin Neurol 27(4):493–501

Article  CAS  PubMed  Google Scholar 

Winkelmann J, Schadrack J, Wetter TC et al (2001) Opioid and dopamine antagonist drug challenges in untreated restless legs syndrome patients. Sleep Med 2(1):57–61

Article  CAS  PubMed  Google Scholar 

Galbiati A, Marelli S, Giora E et al (2015) Neurocognitive function in patients with idiopathic restless legs syndrome before and after treatment with dopamine-agonist. Int J Psychophysiol 95(3):304–309

Article  PubMed  Google Scholar 

Paulus W, Trenkwalder C (2006) Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome. Lancet Neurol 5(10):878–886

Article  CAS  PubMed  Google Scholar 

Connor JR, Boyer PJ, Menzies SL et al (2003) Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61(3):304–309

Article  CAS  PubMed  Google Scholar 

Manconi M, Rocca MA, Ferini-Strambi L et al (2008) Restless legs syndrome is a common finding in multiple sclerosis and correlates with cervical cord damage. Mult Scler 14(1):86–93

Article  CAS  PubMed  Google Scholar 

Baba C, Ozdogar AT, Ozcelik S et al (2022) Relationship between presence of spinal cord lesion and restless legs syndrome in multiple sclerosis. Somatosens Mot Res 39(2–4):116–120

Article  PubMed  Google Scholar 

Frohlich K, Knott M, Hock S et al (2022) Voxel-wise lesion mapping of restless legs syndrome in multiple sclerosis. Neurol Sci 43(8):4953–4959

Article  PubMed  PubMed Central  Google Scholar 

Foschi M, Rizzo G, Liguori R et al (2019) Sleep-related disorders and their relationship with MRI findings in multiple sclerosis. Sleep Med 56:90–95

Article  CAS  PubMed  Google Scholar 

Allen, R. P., et al. (2005). Restless legs syndrome prevalence and impact: REST general population study. Archives of Internal Medicine.

Ohayon, M. M., et al. (2012). Prevalence and characteristics of restless legs syndrome in the general population. Sleep Medicine.

Trenkwalder, C., et al. (2016). Restless legs syndrome: pathophysiology, clinical presentation, and management. Nature Reviews Neurology.

Lichstein, K. L., et al. (2007). Fatigue and sleep disorders. Sleep Medicine Reviews.

Buysse DJ et al (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatr Res. https://doi.org/10.1016/0165-1781(89)90047-4

Article  Google Scholar 

Wali SO et al. (2015) The association between vitamin D deficiency and restless legs syndrome. Annals of Thoracic Medicine

Gao Q et al. (2018) Vitamin D and sleep: a systematic review and meta-analysis. Nutrients

Sateia MJ (2014) International classification of sleep disorders. Chest

Wagner M, Thönnissen E, Winkelmann J et al (2022) Voxel-wise lesion mapping of restless legs syndrome in multiple sclerosis. Front Neurol 13:943872

Google Scholar 

Allen RP, Walters AS, Montplaisir J et al (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165(11):1286–1292

Article  PubMed  Google Scholar 

Ohayon MM, O’Hara R, Vitiello MV (2012) Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev 16(4):283–295

Article  PubMed  Google Scholar 

Lichstein KL, Means MK, Noe SL, Aguillard RN (2007) Fatigue and sleep disorders. Sleep Med Rev 11(5):367–377

Google Scholar 

Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213

Article  CAS  PubMed  Google Scholar 

Joo EY, Kim SH, Lim YH, Koo DL, Hong SB (2012) Reduced cerebral perfusion in the limbic and subcortical structures in restless legs syndrome patients. Eur J Neurol 19(8):1049–1055

Google Scholar 

Park YK, Song JH, Kim HS, Cho YW, Chung S (2022) Restless legs syndrome as a network disorder beyond the dopaminergic system: evidence from neuroimaging studies. Sleep Med Rev 63:101621

Google Scholar 

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