Global Initiative for Chronic Obstructive Lung Disease. Global Strategy For Prevention, Diagnosis and Management of COPD: 2024 Report. https://goldcopd.org/2024-gold-report/ Accessed June 1, 2025, (2024).

Buist, A. S. et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 370, 741–750 (2007).

Article  PubMed  Google Scholar 

WHO. The top 10 causes of death. https://www.who.int/newsroom/fact-sheets/detail/the-top-10-causes-of-death. Accessed June 1, 2025, (2019).

Meghji, J. et al. Improving lung health in low-income and middle-income countries: from challenges to solutions. Lancet 397, 928–940 (2021).

Article  PubMed  Google Scholar 

Chen, S. et al. The global economic burden of chronic obstructive pulmonary disease for 204 countries and territories in 2020–50: a health-augmented macroeconomic modelling study. Lancet Glob. Health 11, e1183–e1193 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathers, C. D. & Loncar, D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3, e442 (2006).

Article  PubMed  PubMed Central  Google Scholar 

Boehm, A. et al. Assessing global COPD awareness with Google Trends. Eur. Respir. J. 53, 1900351 (2019).

Article  PubMed  Google Scholar 

Wang, C. et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet 391, 1706–1717 (2018).

Article  PubMed  Google Scholar 

Zielinski, J. et al. Increasing COPD awareness. Eur. Respir. J. 27, 833–852 (2006).

Article  CAS  PubMed  Google Scholar 

Martinez, C. H. et al. Undiagnosed Obstructive Lung Disease in the United States. Associated Factors and Long-term Mortality. Ann. Am. Thorac. Soc. 12, 1788–1795 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Hill, K. et al. Prevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary care. Cmaj 182, 673–678 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Lamprecht, B. et al. Determinants of underdiagnosis of COPD in national and international surveys. Chest 148, 971–985 (2015).

Article  PubMed  Google Scholar 

Stolz, D. et al. Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission. Lancet 400, 921–972 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ambrosino, N. & Bertella, E. Lifestyle interventions in prevention and comprehensive management of COPD. Breathe 14, 186–194 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Haroon, S. M., Jordan, R. E., O’Beirne-Elliman, J. & Adab, P. Effectiveness of case finding strategies for COPD in primary care: a systematic review and meta-analysis. NPJ Prim. Care Respir. Med. 25, 1–9 (2015).

Article  Google Scholar 

Siu, A. L. et al. Screening for chronic obstructive pulmonary disease: US Preventive Services Task Force recommendation statement. JAMA 315, 1372–1377 (2016).

Article  CAS  PubMed  Google Scholar 

Mangione, C. M. et al. Screening for chronic obstructive pulmonary disease: US preventive services task force reaffirmation recommendation statement. Jama 327, 1806–1811 (2022).

Article  PubMed  Google Scholar 

Yawn, B. P. & Martinez, F. J. Point: can screening for COPD improve outcomes? Yes. Chest 157, 7–9 (2020).

Article  PubMed  Google Scholar 

Yawn, B. P. et al. The impact of screening tools on diagnosis of chronic obstructive pulmonary disease in primary care. Am. J. Prev. Med. 47, 563–575 (2014).

Article  PubMed  Google Scholar 

Zhou, Y. et al. Tiotropium in early-stage chronic obstructive pulmonary disease. N. Engl. J. Med. 377, 923–935 (2017).

Article  CAS  PubMed  Google Scholar 

Haroon, S., Adab, P., Griffin, C. & Jordan, R. Case finding for chronic obstructive pulmonary disease in primary care: a pilot randomised controlled trial. Br. J. Gen. Pract. 63, e55–e62 (2013).

Article  PubMed  Google Scholar 

Jordan, R. E. et al. Targeted case finding for chronic obstructive pulmonary disease versus routine practice in primary care (TargetCOPD): a cluster-randomised controlled trial. Lancet Respir. Med. 4, 720–730 (2016).

Article  PubMed  Google Scholar 

Lambe, T. et al. Model-based evaluation of the long-term cost-effectiveness of systematic case-finding for COPD in primary care. Thorax 74, 730–739 (2019).

Article  PubMed  Google Scholar 

Chen, Q. et al. Cost-effectiveness of population-based screening for chronic obstructive pulmonary disease in China: a simulation modeling study. Lancet Reg. Health West Pac 46, 101065 (2024).

PubMed  PubMed Central  Google Scholar 

Moher, D., Liberati, A., Tetzlaff, J.& Altman, D. G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339, b2535 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Konstantikaki, V. et al. Comparison of a network of primary care physicians and an open spirometry programme for COPD diagnosis. Respir. Med. 105, 274–281 (2011).

Article  PubMed  Google Scholar 

Qu, S. et al. Cost-effectiveness analysis of COPD screening programs in primary care for high-risk patients in China. NPJ Prim. Care Respir. Med. 31, 28 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Behr, C. M., Koffijberg, H., Degeling, K., Vliegenthart, R. & IJzerman, M. J. Can we increase efficiency of CT lung cancer screening by combining with CVD and COPD screening? Results of an early economic evaluation. Eur. Radiol. 32, 3067–3075 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Behr, C. M. et al. Model-Based Cost-Utility Analysis of Combined Low-Dose Computed Tomography Screening for Lung Cancer, Chronic Obstructive Pulmonary Disease, and Cardiovascular Disease. JTO Clin. Res. Rep. 6, 100813 (2025).

PubMed  PubMed Central  Google Scholar 

Drummond, M. F., Sculpher, M. J., Claxton, K., Stoddart, G. L. & Torrance, G. W. Methods for the Economic Evaluation of Health Care Programmes. (Oxford university press, 2015).

Nickel, F., Barth, J. & Kolominsky-Rabas, P. L. Health economic evaluations of non-pharmacological interventions for persons with dementia and their informal caregivers: a systematic review. BMC Geriatr 18, 69 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Beaulieu, E. et al. Economic evaluation in opioid modeling: systematic review. Value Health 24, 158–173 (2021).

Article  PubMed  Google Scholar 

Shields, G. E. et al. Cost-effectiveness of cardiac rehabilitation: a systematic review. Heart 104, 1403–1410 (2018).

Article  PubMed  Google Scholar 

The World Bank. World Bank Open Data. https://data.worldbank.org/.

U.S. Bureau of Labor Statistics. Consumer Price Index. https://www.bls.gov/cpi/.

Zhou, Y. M. et al. Development and validation of a chronic obstructive pulmonary disease screening questionnaire in China. Int J. Tuberc. Lung Dis. 17, 1645–1651 (2013).

Article  PubMed  Google Scholar 

Price, D. B. et al. Symptom-based questionnaire for identifying COPD in smokers. Respiration 73, 285–295 (2006).

Article  PubMed  Google Scholar 

Stanley, A. J., Hasan, I., Crockett, A. J., Van Schayck, O. C. & Zwar, N. A. COPD Diagnostic Questionnaire (CDQ) for selecting at-risk patients for spirometry: a cross-sectional study in Australian general practice. NPJ Prim. Care Respir. Med. 24, 1–5 (2014).

Article  Google Scholar 

Yawn, B. P. et al. Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction. Int J. Chron. Obstruct Pulmon Dis 5, 1–10 (2010).

PubMed