EVADR lncRNA Mitigates Neonatal Hypoxic–Ischemic Brain Injury via the miR-145→WNT/β-Catenin Axis and Exhibits Biomarker Potential

Torres-Cuevas I, Corral-Debrinski M, Gressens P (2019) Brain oxidative damage in murine models of neonatal hypoxia/ischemia and reoxygenation. Free Radic Biol Med 142:3–15

Article  PubMed  CAS  Google Scholar 

Mohammadi A (2024) Bridging preclinical and clinical perspectives: new insights on melatonin’s neuroprotective effects in neonatal rats with Hypoxic-Ischemic brain injury and discovering prognostic biomarkers in patients with traumatic brain injury

Levison SW, Rocha-Ferreira E, Kim BH, Hagberg H, Fleiss B, Gressens P, Dobrowolski R (2022) Mechanisms of tertiary neurodegeneration after neonatal hypoxic-ischemic brain damage. Pediatric Medicine (Hong Kong). 5:28

Jha NK, Chen W-C, Kumar S, Dubey R, Tsai L-W, Kar R, Jha SK, Gupta PK, Sharma A, Gundamaraju R (2022) Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review. Open Biol 12(3):210289

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ilieva MS (2024) Non-coding RNAs in neurological and neuropsychiatric disorders: unraveling the hidden players in disease pathogenesis. Cells 13(12):1063

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ratti M, Lampis A, Ghidini M, Salati M, Mirchev MB, Valeri N, Hahne JC (2020) MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside. Target Oncol 15(3):261–278

Article  PubMed  PubMed Central  Google Scholar 

Li C, Fei K, Tian F, Gao C, Song Y (2019) Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction. Croatian Med J 60(5):439–448

Article  CAS  Google Scholar 

Shi Y, Li K, Xu K, Liu Q-H (2020) MiR-155-5p accelerates cerebral ischemia-reperfusion injury via targeting DUSP14 by regulating NF-κB and MAPKs signaling pathways. Eur Rev Med Pharmacol Sci. 24(3)

Chen Y, Liu W, Chen M, Sun Q, Chen H, Li Y (2021) Up-regulating LncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. Int Immunopharmacol 92:107339

Article  PubMed  CAS  Google Scholar 

Rao G, Zhang W, Song S (2019) MicroRNA-217 Inhibition relieves cerebral ischemia/reperfusion injury by targeting SIRT1. Mol Med Rep 20(2):1221–1229

PubMed  PubMed Central  CAS  Google Scholar 

Shi L, Tian Z, Fu Q, Li H, Zhang L, Tian L, Mi W (2020) miR-217-regulated MEF2D-HDAC5/ND6 signaling pathway participates in the oxidative stress and inflammatory response after cerebral ischemia. Brain Res 1739:146835

Article  PubMed  CAS  Google Scholar 

Zhang S, Sun W-c, Liang Z-d, Yin X-r, Ji Z-r, Chen X-h, Wei M-j, Pei L (2020) LncRNA SNHG4 attenuates inflammatory responses by sponging miR-449c-5p and up-regulating STAT6 in microglial during cerebral ischemia-reperfusion injury. Drug Design Dev Ther. 3683–95

Shangguan Y, Han J, Su H (2020) GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury. Behav Brain Res 379:112370

Article  PubMed  CAS  Google Scholar 

Tu Y, Hu Y (2021) MiRNA-34c-5p protects against cerebral ischemia/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities. Metab Brain Dis 36(6):1341–1351

Article  PubMed  CAS  Google Scholar 

Ye D, Shen Z, Zhou S (2019) Function of microRNA-145 and mechanisms underlying its role in malignant tumor diagnosis and treatment. Cancer Manage Res. 969–979

Gibb EA, Warren RL, Wilson GW, Brown SD, Robertson GA, Morin GB, Holt RA (2015) Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma. Genome Med 7(1):22

Article  PubMed  PubMed Central  Google Scholar 

Song Y, Wen H, Zhai X, Jia L, Li L (2024) Functional bidirectionality of ERV-derived long non-coding RNAs in humans. Int J Mol Sci 25(19):10481

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G (2019) Endogenous retrovirus-derived long noncoding RNA enhances innate immune responses via derepressing RELA expression. MBio 10(4):00937–00919. https://doi.org/10.1128/mbio

Article  Google Scholar 

Jarosz AS, Halo JV (2024) Transcription of endogenous retroviruses: broad and precise mechanisms of control. Viruses 16(8):1312

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alkailani MI, Aittaleb M, Tissir F (2022) WNT signaling at the intersection between neurogenesis and brain tumorigenesis. Front Mol Neurosci 15:1017568

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zuccarini M, Giuliani P, Ziberi S, Carluccio M, Di Iorio P, Caciagli F, Ciccarelli R (2018) The role of Wnt signal in glioblastoma development and progression: a possible new Pharmacological target for the therapy of this tumor. Genes 9(2):105

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Zhang Y, Ding Y, Huang J, Yao J, Xie Z, Lv Y, Zuo J (2022) Regulating the expression of HIF-1α or lncrna: potential directions for cancer therapy. Cells 11(18):2811

Article  PubMed  PubMed Central  Google Scholar 

Bandarra D, Biddlestone J, Mudie S, Müller H-AJ, Rocha S (2015) HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. Dis Models Mech 8(2):169–181

Google Scholar 

Zeng G, Apte U, Cieply B, Singh S, Monga SP (2007) siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia 9(11):951–959

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng D, Bao Y, Wang X, Xiang H, Guo T, Du Y, Zhang Z, Guo H (2025) WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway. Eur J Med Res 30(1):68

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wen Q, Wittens MMJ, Engelborghs S, van Herwijnen MH, Tsamou M, Roggen E, Smeets B, Krauskopf J, Briedé JJ (2024) Beyond CSF and neuroimaging assessment: evaluating plasma miR-145-5p as a potential biomarker for mild cognitive impairment and alzheimer’s disease. ACS Chem Neurosci 15(5):1042–1054

Article  PubMed  CAS  Google Scholar 

D’Ignazio L, Bandarra D, Rocha S (2016) NF-κB and HIF crosstalk in immune responses. FEBS J 283(3):413–424

Article  PubMed  Google Scholar 

Xu W-X, Liu Z, Deng F, Wang D-D, Li X-W, Tian T, Zhang J, Tang J-H (2019) MiR-145: a potential biomarker of cancer migration and invasion. Am J Transl Res 11(11):6739

PubMed  PubMed Central  CAS  Google Scholar 

Xu L, Zhang Y, Tang J, Wang P, Li L, Yan X, Zheng X, Ren S, Zhang M, Xu M (2019) The prognostic value and regulatory mechanisms of microRNA-145 in various tumors: a systematic review and meta-analysis of 50 studies. Cancer Epidemiol Biomark Prev 28(5):867–881

Article  CAS  Google Scholar 

Sachdeva M, Mo Y-Y (2010) miR-145-mediated suppression of cell growth, invasion and metastasis. Am J Transl Res 2(2):170

CAS  Google Scholar 

Agostini R, Ceccaroli P, Polidori E, Ferracin M, Pace I, Maggio S, Cioccoloni A, Battistelli M, Matacchione G, Sbriscia M (2025) Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting achr clustering. Cell Commun Sign 23(1):360

Article  CAS  Google Scholar 

Zappaterra MW, Lehtinen MK (2012) The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci 69(17):2863–2878

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sporn K, Kumar R, Marla K, Ravi P, Vaja S, Paladugu P, Zaman N, Tavakkoli A (2025) Epigenetic profiling of Cell-Free DNA in cerebrospinal fluid: a novel biomarker approach for metabolic brain diseases. Life 15(8):1181

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim SH, Chae SA (2021) Promising candidate cerebrospinal fluid biomarkers of seizure disorder, infection, inflammation, tumor, and traumatic brain injury in pediatric patients. Clin Exp Pediatr 65(2):56

Article  PubMed  PubMed Central  Google Scholar 

Drusco A, Bottoni A, Laganà A, Acunzo M, Fassan M, Cascione L, Antenucci A, Kumchala P, Vicentini C, Gardiman MP (2015) A differentially expressed set of MicroRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies. Oncotarget 6(25):20829

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