Do Canto AM, Donatti A, Geraldis JC et al (2021) Neuroproteomics in epilepsy: what do we know so far? Front Mol Neurosci 13:1–18. https://doi.org/10.3389/fnmol.2020.604158
Dua T, De Boer HM, Prilipko LL, Saxena S (2006) Epilepsy care in the world: results of an ILAE/IBE/WHO global campaign against epilepsy survey. Epilepsia 47:1225–1231. https://doi.org/10.1111/j.1528-1167.2006.00595.x
Shingalapur RV, Hosamani KM, Keri RS, Hugar MH (2010) Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies. Eur J Med Chem 45:1753–1759. https://doi.org/10.1016/j.ejmech.2010.01.007
Article PubMed CAS Google Scholar
Imran I, Hillert MH, Klein J (2015) Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. J Neurochem 135:1007–1018. https://doi.org/10.1111/jnc.13360
Article PubMed CAS Google Scholar
Sasa M (2006) A new frontier in epilepsy: novel antiepileptogenic drugs. J Pharmacol Sci 100:487–494. https://doi.org/10.1254/jphs.CPJ06010X
Article PubMed CAS Google Scholar
Vezzani A, Aronica E, Mazarati A, Pittman QJ (2013) Epilepsy and brain inflammation. Exp Neurol 244:11–21. https://doi.org/10.1016/j.expneurol.2011.09.033
Article PubMed CAS Google Scholar
Paudel YN, Shaikh MF, Shah S et al (2018) Role of inflammation in epilepsy and neurobehavioral comorbidities: implication for therapy. Eur J Pharmacol 837:145–155. https://doi.org/10.1016/j.ejphar.2018.08.020
Article PubMed CAS Google Scholar
McNamara JO, Huang YZ, Leonard AS (2006) Molecular signaling mechanisms underlying epileptogenesis. Sci STKE. https://doi.org/10.1126/stke.3562006re12. 2006:
Al-Obaidi JR, Jambari NN, Ahmad-Kamil EI (2021) Mycopharmaceuticals and nutraceuticals: promising agents to improve human well-being and life quality. J Fungi 7:1–21. https://doi.org/10.3390/jof7070503
Bulam S, Üstün NŞ, Pekşen A (2019) Health benefits of ganoderma lucidum as a medicinal mushroom. Turkish J Agric - Food Sci Technol 7:84–93. https://doi.org/10.24925/turjaf.v7isp1.84-93.2728
Ahmad MF (2018) Ganoderma lucidum: persuasive biologically active constituents and their health endorsement. Biomed Pharmacother 107:507–519. https://doi.org/10.1016/j.biopha.2018.08.036
Article PubMed CAS Google Scholar
Sun XZ, Liao Y, Li W, Guo LM (2017) Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Neural Regen Res 12:953–958. https://doi.org/10.4103/1673-5374.208590
Article PubMed PubMed Central CAS Google Scholar
Zhou Y, Qu Z, qiang, Zeng Y, shan et al (2012) Neuroprotective effect of preadministration with ganoderma lucidum spore on rat hippocampus. Exp Toxicol Pathol 64:673–680. https://doi.org/10.1016/j.etp.2010.12.011
Li P, Liu L, Huang S et al (2020) Anti-cancer effects of a neutral triterpene fraction from ganoderma lucidum and its active constituents on SW620 human colorectal cancer cells. Anticancer Agents Med Chem 20:237–244. https://doi.org/10.2174/1871520619666191015102442
Article PubMed CAS Google Scholar
Itto rahou A, Aboubaker E-H, Youssef B et al (2025) Evaluation of the potential anticonvulsant and neuroprotective effects of ganoderma lucidum extract in an animal model of pentylenetetrazol-induced seizures. Neurochem Res 50:279. https://doi.org/10.1007/s11064-025-04536-2
Tong A, Wu W, Chen Z et al (2023) Current research in food science modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by ganoderma lucidum triterpenoids. Curr Res Food Sci 6:100427. https://doi.org/10.1016/j.crfs.2022.100427
Article PubMed CAS Google Scholar
Ahmed H, Aslam M (2018) Evaluation of aphrodisiac activity of ethanol extract of ganoderma lucidum in male Wistar rats. Clin Phytoscience 26:4–26. https://doi.org/10.1186/s40816-018-0086-7
Muke S, Kaikini A, Peshattiwar V et al (2018) Neuroprotective effect of coumarin nasal formulation: kindling model assessment of epilepsy. Front Pharmacol 9:1–16. https://doi.org/10.3389/fphar.2018.00992
Akif Q, Kurt H, Bosnak M et al (2015) Pharmacological reports epileptogenic effects of G protein-coupled Estrogen receptor 1 in the rat Pentylenetetrazole kindling model of epilepsy. Pharmacol Rep 374:1–5. https://doi.org/10.1016/j.pharep.2015.07.001
Maciejak P, Szyndler J, Lehner M et al (2010) The differential effects of protein synthesis Inhibition on the expression and reconsolidation of Pentylenetetrazole kindled seizures. Epilepsy Behav 18:193–200. https://doi.org/10.1016/j.yebeh.2010.04.005
Badawi GA, Shokr MM, Elshazly SM et al (2024) Sigma-1 receptor modulation by clemastine highlights its repurposing as neuroprotective agent against seizures and cognitive deficits in PTZ-kindled rats. Eur J Pharmacol 980:176851. https://doi.org/10.1016/j.ejphar.2024.176851
Article PubMed CAS Google Scholar
Mizoguchi H, Nakade J, Tachibana M et al (2011) Matrix metalloproteinase-9 contributes to kindled seizure development in Pentylenetetrazole-Treated mice by converting Pro-BDNF to mature BDNF in the hippocampus. J Neurosci 31:12963–12971. https://doi.org/10.1523/JNEUROSCI.3118-11.2011
Article PubMed PubMed Central CAS Google Scholar
Shan W, Ding Y, Ding XY et al (2016) Effectiveness of ketogenic diet in pentylenetetrazol-induced and kindling rats as well as its potential mechanisms. Neurosci Lett 614:1–6. https://doi.org/10.1016/j.neulet.2015.12.058
Eroğlu HA, Beytut E (2018) Effect of ganoderma lucidum polysaccharides on oxidative damage in liver of STZ-diabetic rats. Biomed Res 29:3436–3443. https://doi.org/10.4066/biomedicalresearch.29-18-831
Nieoczym D, Socała K, Zelek-Molik A et al (2021) Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies. Psychopharmacology 238:3167–3181. https://doi.org/10.1007/s00213-021-05933-5
Article PubMed PubMed Central CAS Google Scholar
Hughes RN (2004) The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 28:497–505. https://doi.org/10.1016/j.neubiorev.2004.06.006
Article PubMed CAS Google Scholar
Sierksma ASR, Van Den Hove DLA, Pfau F et al (2014) Improvement of Spatial memory function in APPswe/PS1dE9 mice after chronic Inhibition of phosphodiesterase type 4D. Neuropharmacology 77:120–130. https://doi.org/10.1016/j.neuropharm.2013.09.015
Article PubMed CAS Google Scholar
Rossato BJS, Da Silva WC et al (2007) On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of Spatial memory. Neuroscience 147:37–45. https://doi.org/10.1016/j.neuroscience.2007.04.013
Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–858. https://doi.org/10.1038/nprot.2006.116
Article PubMed PubMed Central Google Scholar
Green LC, Ruiz K, Luzuriaga DE et al (1981) Nitrate biosynthesis in man (metabolism/stable isotopes/carcinogenesis)
Ayala A, Muñoz MF, Argüelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014:1–31. https://doi.org/10.1155/2014/360438
Comments (0)