(2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390:1211–1259. https://doi.org/10.1016/S0140-6736(17)32154-2

Buchbinder R, Underwood M, Hartvigsen J, Maher CG (2020) The Lancet series call to action to reduce low value care for low back pain: an update. Pain 161(1):S57–S64. https://doi.org/10.1097/j.pain.0000000000001869

Article  PubMed  PubMed Central  Google Scholar 

Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR (1988) Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 166:193–199

Article  CAS  PubMed  Google Scholar 

Modic MT, Masaryk TJ, Ross JS, Carter JR (1988) Imaging of degenerative disk disease. Radiology 168:177–186

Article  CAS  PubMed  Google Scholar 

Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M (2022) A definition and clinical grading of Modic changes. J Orthop Res 40:301–307. https://doi.org/10.1002/jor.25240

Article  PubMed  Google Scholar 

Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC (2016) Pathobiology of Modic changes. Eur Spine J 25:3723–3734

Article  PubMed  Google Scholar 

Dudli S, Sing DC, Hu SS, Berven SH, Burch S, Deviren V, Cheng I, Tay BKB, Alamin TF, Ith MAM, Pietras EM, Lotz JC (2017) ISSLS prize in basic science 2017: intervertebral disc/bone marrow cross-talk with Modic changes. Eur Spine J 26:1362–1373. https://doi.org/10.1007/s00586-017-4955-4

Article  PubMed  Google Scholar 

Nian S, Tang S, Shen S, Yue W, Zhao C, Zou T, Li W, Li N, Lu S, Chen J (2024) Landscape of the lumbar cartilaginous end plate microbiota and metabolites in patients with Modic changes. J Bone Joint Surg Am. https://doi.org/10.2106/JBJS.23.00805

Article  PubMed  Google Scholar 

Ramos LAV, França FJR, Callegari B, Burke TN, Magalhães MO, Marques AP (2016) Are lumbar multifidus fatigue and transversus abdominis activation similar in patients with lumbar disc herniation and healthy controls? A case control study. Eur Spine J 25:1435–1442. https://doi.org/10.1007/s00586-015-4375-2

Article  PubMed  Google Scholar 

Mitra D, Cassar-Pullicino VN, McCall IW (2004) Longitudinal study of vertebral type-1 end-plate changes on MR of the lumbar spine. Eur Radiol 14:1574–1581

Article  CAS  PubMed  Google Scholar 

Kuisma M, Karppinen J, Niinimäki J, Ojala R, Haapea M, Heliövaara M, Korpelainen R, Taimela S, Natri A, Tervonen O (2007) Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine 32:1116–1122

Article  PubMed  Google Scholar 

Feng X, Nian S, Chen J, Li N, Duan P (2024) Modic changes in patients with lumbar disc herniation followed more than 1 year after lumbar discectomy: a systematic review and meta-analysis. PeerJ 12:e17851. https://doi.org/10.7717/peerj.17851

Article  PubMed  PubMed Central  Google Scholar 

Nian S, Li N, Kong F, Lu S, Chen J (2023) Is discectomy effective for treating low back pain in patients with lumbar disc herniation and Modic changes? A systematic review and meta-analysis of cohort studies. Spine J 23:533–549. https://doi.org/10.1016/j.spinee.2022.10.008

Article  PubMed  Google Scholar 

Espeland A, Kristoffersen PM, Bråten LCH, Grøvle L, Grotle M, Haugen AJ, Rolfsen MP, Hellum C, Zwart J-A, Storheim K, Assmus J, Vetti N (2023) Longitudinal relationship between reduced Modic change edema and disability and pain in patients with chronic low back pain. Spine 48:1699–1708. https://doi.org/10.1097/BRS.0000000000004837

Article  PubMed  PubMed Central  Google Scholar 

Gillies RJ, Kinahan PE, Hricak H (2016) Radiomics: images are more than pictures, they are data. Radiology 278:563–577. https://doi.org/10.1148/radiol.2015151169

Article  PubMed  Google Scholar 

Lambin P, Leijenaar RTH, Deist TM, Peerlings J, de Jong EEC, van Timmeren J, Sanduleanu S, Larue RTHM, Even AJG, Jochems A, van Wijk Y, Woodruff H, van Soest J, Lustberg T, Roelofs E, van Elmpt W, Dekker A, Mottaghy FM, Wildberger JE, Walsh S (2017) Radiomics: the bridge between medical imaging and personalized medicine. Nat Rev Clin Oncol 14:749–762. https://doi.org/10.1038/nrclinonc.2017.141

Article  PubMed  Google Scholar 

Jamaludin A, Lootus M, Kadir T, Zisserman A, Urban J, Battié MC, Fairbank J, McCall I (2017) ISSLS prize in bioengineering science 2017: automation of reading of radiological features from magnetic resonance images (MRIs) of the lumbar spine without human intervention is comparable with an expert radiologist. Eur Spine J 26:1374–1383. https://doi.org/10.1007/s00586-017-4956-3

Article  PubMed  Google Scholar 

Nian S, Zhao Y, Li C, Zhu K, Li N, Li W, Chen J (2024) Development and validation of a radiomics-based model for predicting osteoporosis in patients with lumbar compression fractures. Spine J 24:1625–1634. https://doi.org/10.1016/j.spinee.2024.04.016

Article  PubMed  Google Scholar 

Riley RD, Snell KIE, Archer L, Ensor J, Debray TPA, van Calster B, van Smeden M, Collins GS (2024) Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study. BMJ 384:e074821. https://doi.org/10.1136/bmj-2023-074821

Article  PubMed  PubMed Central  Google Scholar 

Riley RD, Ensor J, Snell KIE, Harrell FE, Martin GP, Reitsma JB, Moons KGM, Collins G, van Smeden M (2020) Calculating the sample size required for developing a clinical prediction model. BMJ 368:m441. https://doi.org/10.1136/bmj.m441

Article  PubMed  Google Scholar 

Gao KT, Tibrewala R, Hess M, Bharadwaj UU, Inamdar G, Link TM, Chin CT, Pedoia V, Majumdar S (2022) Automatic detection and voxel-wise mapping of lumbar spine Modic changes with deep learning. JOR Spine 5:e1204. https://doi.org/10.1002/jsp2.1204

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Griethuysen JJM, Fedorov A, Parmar C, Hosny A, Aucoin N, Narayan V, Beets-Tan RGH, Fillion-Robin J-C, Pieper S, Aerts HJWL (2017) Computational radiomics system to decode the radiographic phenotype. Cancer Res 77:e104–e107. https://doi.org/10.1158/0008-5472.CAN-17-0339

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yüksek M, Yokuş A, Arslan H, Canayaz M, Akdemir Z (2024) The success of deep learning modalities in evaluating Modic changes. World Neurosurg 184:e354–e359. https://doi.org/10.1016/j.wneu.2024.01.129

Article  PubMed  Google Scholar 

Liu G, Wang L, You S-N, Wang Z, Zhu S, Chen C, Ma X-L, Yang L, Zhang S, Yang Q (2024) Automatic detection and classification of Modic changes in MRI images using deep learning: intelligent assisted diagnosis system. Orthop Surg 16:196–206. https://doi.org/10.1111/os.13894

Article  CAS  PubMed  Google Scholar 

Teraguchi M, Hashizume H, Oka H, Cheung JPY, Samartzis D, Tamai H, Muraki S, Akune T, Tanaka S, Yoshida M, Yoshimura N, Yamada H (2021) Detailed subphenotyping of lumbar Modic changes and their association with low back pain in a large population-based study: the Wakayama Spine Study. Pain Ther 11:57–71. https://doi.org/10.1007/s40122-021-00337-x

Article  PubMed  PubMed Central  Google Scholar 

Wei H, Lu H, Li L, Qu C, Zhang H, Ma X (2025) Bibliometric and visualized analysis of research relating to spinal Modic changes reported over the period 2004–2024. Orthop Surg 17:3185–3200. https://doi.org/10.1111/os.70162

Article  PubMed  PubMed Central  Google Scholar 

Chen R, Zou K, Liu J, Li K, Zhou Y, Huang H, Yang F (2024) Do modic changes affect the fusion rate in spinal interbody fusion surgery? A systematic review and network meta-analysis. J Clin Neurosci 125:110–119. https://doi.org/10.1016/j.jocn.2024.05.019

Article  PubMed  Google Scholar 

Xiao Y, Zhu C, Xiu P, Wang L, Zhang Z, Deng Z, Song Y, Yang X (2024) Postoperative sclerotic Modic changes after transforaminal lumbar interbody fusion: the prevalence, risk factors, and impact on fusion. Spine 49:E135–E141. https://doi.org/10.1097/BRS.0000000000004890

Article  PubMed  Google Scholar 

Feng ZY, Hu XJ, Zheng QQ, Battié MC, Chen Z, Wang Y (2021) Cartilaginous endplate avulsion is associated with modic changes and endplate defects, and residual back and leg pain following lumbar discectomy. Osteoarthritis Cartilage 29:707–717. https://doi.org/10.1016/j.joca.2021.01.010

Article  CAS  PubMed