Use of Sodium Butyrate and Its Microencapsulated Forms in Intestinal Diseases—Current Clinical Approach

Kaźmierczak-Siedlecka K, Marano L, Merola E, Roviello F, Połom K. Sodium butyrate in both prevention and supportive treatment of colorectal cancer. Front Cell Infect Microbiol. 2022;12:1023806. https://doi.org/10.3389/fcimb.2022.1023806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016;7:189–200. https://doi.org/10.1080/19490976.2015.1134082.

Article  PubMed  PubMed Central  Google Scholar 

Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EM, Sanders ME, Shamir R, Swann JR, Szajewska H, Vinderola G. The international scientific association of probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021;18:649–667. https://doi.org/10.1038/s41575-021-00440-6.

Article  PubMed  PubMed Central  Google Scholar 

Banasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Determination of butyric acid dosage based on clinical and experimental studies - a literature review. Gastroenterol Rev. 2020;15:119–125. https://doi.org/10.5114/pg.2020.95556.

Article  CAS  Google Scholar 

Chen H, Qian Y, Jiang C, Tang L, Yu J, Zhang L, Dai Y, Jiang G. Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier. Biochim Biophys Acta Mol Basis Dis 2024;1870:166984. https://doi.org/10.1016/j.bbadis.2023.166984.

Article  CAS  PubMed  Google Scholar 

Tarnowski W, Borycka-Kiciak K, Kiciak A, Friediger J, Cienciała A, Zabielski R. Outcome of treatment with butyric acid in irritable bowel syndrome – preliminary report. Gastroenterologia Praktyczna. 2011;1.

Banasiewicz T, Kaczmarek E, Maik J, Stojcev Z, Marciniak R, Krokowicz P, Drews M. Quality of life and clinical symptoms in patients with irritable bowel syndrome receiving complementary treatment with protected sodium butyrate. Gastroenterologia Praktyczna. 2011;5.

Banasiewicz T, Krokowicz Ł, Stojcev Z, Kaczmarek BF, Kaczmarek E, Maik J, Marciniak R, Krokowicz P, Walkowiak J, Drews M. Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome. Colorectal Dis. 2013;15:204–209. https://doi.org/10.1111/j.1463-1318.2012.03152.x.

Article  CAS  PubMed  Google Scholar 

Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, Padysz M, Siedlecka M, Bierła JB, Steinert RE, Cukrowska B. Effects of microencapsulated sodium butyrate, probiotics and short chain fructooligosaccharides in patients with irritable bowel syndrome: a study protocol of a randomized double-blind placebo-controlled trial. J Clin Med. 2022;11:6587. https://doi.org/10.3390/jcm11216587.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewandowski K, Kaniewska M, Karłowicz K, Rosołowski M, Rydzewska G. The effectiveness of microencapsulated sodium butyrate at reducing symptoms in patients with irritable bowel syndrome. Gastroenterology Rev. 2022;17:28–34. https://doi.org/10.5114/pg.2021.112681.

Article  CAS  Google Scholar 

Panufnik P, Więcek M, Szwarc P, Kaniewska M, Lewandowski K, Franek E, Rydzewska G. Effect of butyrate on GI signs, SIBO, and diabetes control—randomized, placebo-controlled study in patients with type 2 diabetes. Diabetes. 2024;73:610. https://doi.org/10.2337/db24-610-P.

Article  Google Scholar 

Goldiș A, Dragomir R, Mercioni MA, Sirca D, Goldiș C, Enatescu I, Olariu L, Belei O. Clinical efficacy of sodium butyrate in managing pediatric inflammatory bowel disease. Life (Basel). 2025;15:902. https://doi.org/10.3390/life15060902.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guilloteau P, Martin L, Eeckhaut V, Ducatelle R, Zabielski R, Van Immerseel F. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev. 2010;23:366–384. https://doi.org/10.1017/S0954422410000247.

Article  CAS  PubMed  Google Scholar 

Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011;17:1519–1528. https://doi.org/10.3748/wjg.v17.i12.1519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salvi PS, Cowles RA. Butyrate and the intestinal epithelium: modulation of proliferation and inflammation in homeostasis and disease. Cells. 2021;10:1775. https://doi.org/10.3390/cells10071775.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siddiqui MT, Cresci GAM. The Immunomodulatory functions of butyrate. J Inflamm Res. 2021;14:6025–6041. https://doi.org/10.2147/JIR.S300989.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin-Gallausiaux C, Marinelli L, Blottière HM, Larraufie P, Lapaque N. SCFA: mechanisms and functional importance in the gut. Proc Nutr Soc. 2021;80:37–49. https://doi.org/10.1017/S0029665120006916.

Article  CAS  PubMed  Google Scholar 

Hodgkinson K, El Abbar F, Dobranowski P, Manoogian J, Butcher J, Figeys D, Mack D, Stintzi A. Butyrate’s role in human health and the current progress towards its clinical application to treat gastrointestinal disease. Clin Nutr. 2023;42:61–75. https://doi.org/10.1016/j.clnu.2022.10.024.

Article  CAS  PubMed  Google Scholar 

Xu S, Liu CX, Xu W, Huang L, Zhao JY, Zhao SM. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduct Target Ther. 2017;2:16035. https://doi.org/10.1038/sigtrans.2016.35.

Article  PubMed  PubMed Central  Google Scholar 

Zeng H, Hamlin SK, Safratowich BD, Cheng WH, Johnson LK. Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis: linking dietary fiber to cancer prevention. Nutr Res. 2020;83:63–72. https://doi.org/10.1016/j.nutres.2020.08.009.

Article  CAS  PubMed  Google Scholar 

Astbury SM, Corfe BM. Uptake and metabolism of the short-chain fatty acid butyrate, a critical review of the literature. Curr Drug Metab. 2012;13:815–821. https://doi.org/10.2174/138920012800840428.

Article  CAS  PubMed  Google Scholar 

Geirnaert A, Calatayud M, Grootaert C, Laukens D, Devriese S, Smagghe G, De Vos M, Boon N, Van de Wiele T. Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity. Sci Rep. 2017;7:11450. https://doi.org/10.1038/s41598-017-11734-11738.

Article  PubMed  PubMed Central  Google Scholar 

Bach Knudsen KE, Lærke HN, Hedemann MS, Nielsen TS, Ingerslev AK, Gundelund Nielsen DS, Theil PK, Purup S, Hald S, Schioldan AG, Marco ML, Gregersen S, Hermansen K. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients. 2018;10:1499. https://doi.org/10.3390/nu10101499.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pietrzak A, Banasiewicz T. Applicability of sodium butyrate preparations from a surgeon’s and gastroenterologist’s perspective. Pol Przegl Chir. 2024;96:68–73. https://doi.org/10.5604/01.3001.0054.4152.

Article  PubMed  Google Scholar 

Borycka-Kiciak K, Banasiewicz T, Rydzewska G. Butyric acid - a well-known molecule revisited. Gastroenterol Rev. 2017;12:83–89. https://doi.org/10.5114/pg.2017.68342.

Article  CAS  Google Scholar 

La Monica MB, Kirby T, Hartshorn SL, Gustat A, Grdic J, Sandrock J. A pharmacokinetic comparison of three butyrate products. J Exercise Nutr. 2025;8:4. https://doi.org/10.53520/jen2025.103189.

Article  Google Scholar 

Banasiewicz T, Borycka-Kiciak K, Dobrowolska-Zachwieja A et al. Clinical aspects of sodium butyrate application in dietary treatment of bowel diseases. Gastroenterol Rev. 2010;5:329–334. https://doi.org/10.5114/pg.2010.18476.

Article  Google Scholar 

Smith DJ, Barri A, Herges G, Hahn J, Yersin AG, Jourdan A. In vitro dissolution and in vivo absorption of calcium [1-(14)c]butyrate in free or protected forms. J Agric Food Chem. 2012;60:3151–3157. https://doi.org/10.1021/jf3001058.

Article  CAS  PubMed  Google Scholar 

Facchin S, Vitulo N, Calgaro M, Buda A, Romualdi C, Pohl D, Perini B, Lorenzon G, Marinelli C, D’Incà R, Sturniolo GC, Savarino EV. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterol Motil. 2020;32:e13914. https://doi.org/10.1111/nmo.13914.

Article  CAS 

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