Pressure applied: Mechanisms affecting heart–lung interactions and cardiac filling in patients with HFpEF during rest and exercise

Borlaug BA (2014) The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 11:507–515. https://doi.org/10.1038/nrcardio.2014.83

Article  CAS  PubMed  Google Scholar 

Nair N (2020) Epidemiology and pathogenesis of heart failure with preserved ejection fraction. Rev Cardiovasc Med 21:531–540. https://doi.org/10.31083/j.rcm.2020.04.154

Article  PubMed  Google Scholar 

Mishra S, Kass DA (2021) Publisher correction: cellular and molecular pathobiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 18:735. https://doi.org/10.1038/s41569-021-00516-5

Article  PubMed  Google Scholar 

Youn JC, Ahn Y, Jung HO (2021) Pathophysiology of heart failure with preserved ejection fraction. Heart Fail Clin 17:327–335. https://doi.org/10.1016/j.hfc.2021.02.001

Article  PubMed  Google Scholar 

Nagueh SF (2021) Heart failure with preserved ejection fraction: insights into diagnosis and pathophysiology. Cardiovasc Res 117:999–1014. https://doi.org/10.1093/cvr/cvaa228

Article  CAS  PubMed  Google Scholar 

Fayyaz AU, Eltony M, Prokop LJ, Koepp KE, Borlaug BA, Dasari S, Bois MC, Margulies KB, Maleszewski JJ, Wang Y et al (2024) Pathophysiological insights into HFpEF from studies of human cardiac tissue. Nat Rev Cardiol. https://doi.org/10.1038/s41569-024-01067-1

Article  PubMed  PubMed Central  Google Scholar 

van Heerebeek L, Franssen CP, Hamdani N, Verheugt FW, Somsen GA, Paulus WJ (2012) Molecular and cellular basis for diastolic dysfunction. Curr Heart Fail Rep 9:293–302. https://doi.org/10.1007/s11897-012-0109-5

Article  CAS  PubMed  Google Scholar 

Obokata M, Reddy YNV, Borlaug BA (2020) Diastolic dysfunction and heart failure with preserved ejection fraction: understanding mechanisms by using noninvasive methods. JACC Cardiovasc Imaging 13:245–257. https://doi.org/10.1016/j.jcmg.2018.12.034

Article  PubMed  Google Scholar 

Noble MI (1978) The Frank-Starling curve. Clin Sci Mol Med 54:1–7. https://doi.org/10.1042/cs0540001

Article  CAS  PubMed  Google Scholar 

Levine BD, Lane LD, Buckey JC, Friedman DB, Blomqvist CG (1991) Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance. Circulation 84:1016–1023. https://doi.org/10.1161/01.cir.84.3.1016

Article  CAS  PubMed  Google Scholar 

Hieda M, Howden E, Shibata S, Tarumi T, Lawley J, Hearon CM Jr, Palmer D, Fu Q, Zhang R, Sarma S et al (1985) Preload-corrected dynamic Starling mechanism in patients with heart failure with preserved ejection fraction. J Appl Physiol 2018(124):76–82. https://doi.org/10.1152/japplphysiol.00718.2017

Article  CAS  Google Scholar 

Zile MR, Baicu CF, Gaasch WH (2004) Diastolic heart failure–abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med 350:1953–1959. https://doi.org/10.1056/NEJMoa032566

Article  CAS  PubMed  Google Scholar 

Fujimoto N, Prasad A, Hastings JL, Bhella PS, Shibata S, Palmer D, Levine BD (2012) Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction. Am Heart J 164:869–877. https://doi.org/10.1016/j.ahj.2012.06.028

Article  PubMed  Google Scholar 

Shibata S, Hastings JL, Prasad A, Fu Q, Bhella PS, Pacini E, Krainski F, Palmer MD, Zhang R, Levine BD (1985) Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism. J Appl Physiol 2011(110):964–971. https://doi.org/10.1152/japplphysiol.00826.2010

Article  Google Scholar 

Pieske B, Tschope C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP et al (2019) How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 40:3297–3317. https://doi.org/10.1093/eurheartj/ehz641

Article  PubMed  Google Scholar 

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37:2129–2200. https://doi.org/10.1093/eurheartj/ehw128

Article  PubMed  Google Scholar 

Eisman AS, Shah RV, Dhakal BP, Pappagianopoulos PP, Wooster L, Bailey C, Cunningham TF, Hardin KM, Baggish AL, Ho JE et al (2018) Pulmonary capillary wedge pressure patterns during exercise predict exercise capacity and incident heart failure. Circ Heart Fail 11:e004750. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004750

Article  PubMed  PubMed Central  Google Scholar 

Huang W, Oliveira RKF, Lei H, Systrom DM, Waxman AB (2018) Pulmonary vascular resistance during exercise predicts long-term outcomes in heart failure with preserved ejection fraction. J Card Fail 24:169–176. https://doi.org/10.1016/j.cardfail.2017.11.003

Article  CAS  PubMed  Google Scholar 

Thompson RB, Pagano JJ, Chow K, Sekowski V, Paterson I, Ezekowitz J, Anderson T, Dyck JRB, Haykowsky MJ, Alberta HEART investigators (2017) Subclinical pulmonary edema is associated with reduced exercise capacity in HFpEF and HFrEF. J Am Coll Cardiol 70:1827–1828. https://doi.org/10.1016/j.jacc.2017.07.787

Reddy YNV, Obokata M, Wiley B, Koepp KE, Jorgenson CC, Egbe A, Melenovsky V, Carter RE, Borlaug BA (2019) The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction. Eur Heart J 40:3721–3730. https://doi.org/10.1093/eurheartj/ehz713

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarma S, MacNamara JP, Balmain BN, Hearon CM Jr, Wakeham DJ, Tomlinson AR, Hynan LS, Babb TG, Levine BD (2023) Challenging the hemodynamic hypothesis in heart failure with preserved ejection fraction: is exercise capacity limited by elevated pulmonary capillary wedge pressure? Circulation 147:378–387. https://doi.org/10.1161/CIRCULATIONAHA.122.061828

Article  CAS  PubMed  Google Scholar 

Babb TG, Balmain BN, Tomlinson AR, Hynan LS, Levine BD, MacNamara JP, Sarma S (2023) Ventilatory limitations in patients with HFpEF and obesity. Respir Physiol Neurobiol 318:104167. https://doi.org/10.1016/j.resp.2023.104167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villarraga N, Warner B, Bruhn EJ, Hammer SM, Bissen TG, Olson TP, Smith JR (2023) Higher work of breathing during exercise in heart failure with preserved ejection fraction. Chest 163:1492–1505. https://doi.org/10.1016/j.chest.2022.11.039

Article  PubMed  Google Scholar 

O’Donnell DE, Revill SM, Webb KA (2001) Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164:770–777. https://doi.org/10.1164/ajrccm.164.5.2012122

Article  PubMed  Google Scholar 

Sheel AW, Dominelli PB, Molgat-Seon Y (2016) Revisiting dysanapsis: sex-based differences in airways and the mechanics of breathing during exercise. Exp Physiol 101:213–218. https://doi.org/10.1113/EP085366

Article  PubMed  Google Scholar 

Cheyne WS, Gelinas JC, Eves ND (2018) Hemodynamic effects of incremental lung hyperinflation. Am J Physiol Heart Circ Physiol 315:H474–H481. https://doi.org/10.1152/ajpheart.00229.2018

Article  CAS  PubMed  Google Scholar 

Balmain BN, Tomlinson AR, MacNamara JP, Hynan LS, Wakeham DJ, Levine BD, Sarma S, Babb TG (2023) Reducing pulmonary capillary wedge pressure during exercise exacerbates exertional dyspnea in patients with heart failure with preserved ejection fraction: implications for V˙/Q˙ mismatch. Chest 164:686–699. https://doi.org/10.1016/j.chest.2023.04.003

Article  PubMed  PubMed Central  Google Scholar 

Brecher GA, Hubay CA (1955) Pulmonary blood flow and venous return during spontaneous respiration. Circ Res 3:210–214. https://doi.org/10.1161/01.res.3.2.210

Article  CAS  PubMed  Google Scholar 

Cheyne WS, Gelinas JC, Eves ND (2018) The haemodynamic response to incremental increases in negative intrathoracic pressure in healthy humans. Exp Physiol 103:581–589. https://doi.org/10.1113/EP086654

Article  PubMed 

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