Heart failure and chronic obstructive pulmonary disease. A combination not to be underestimated

Boers E, Barrett M, Su JG et al (2023) Global burden of chronic obstructive pulmonary disease through 2050. JAMA Netw Open 6(12):e2346598. https://doi.org/10.1001/jamanetworkopen.2023.46598

Article  PubMed  PubMed Central  Google Scholar 

Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS (2023) Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res 118(17):3272–3287. https://doi.org/10.1093/cvr/cvac013

Article  PubMed  CAS  Google Scholar 

Rosano GMC, Teerlink JR, Kinugawa K et al (2025) The use of left ventricular ejection fraction in the diagnosis and management of heart failure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC, the Heart Failure Society of America (HFSA), and the Japanese Heart Failure Society (JHFS). Eur J Heart Fail 27(7):1174–1187. https://doi.org/10.1002/ejhf.3646

Article  PubMed  Google Scholar 

Basile C, Maggioni AP (2025) Heart failure in an ageing world: closing the evidence-equity gap. Eur Heart J Qual Care Clin Outcomes: qcaf046. https://doi.org/10.1093/ehjqcco/qcaf046. (Published online June 25)

Lagan J, Schelbert EB, Naish JH et al (2021) Mechanisms underlying the association of chronic obstructive pulmonary disease with heart failure. JACC Cardiovasc Imaging 14(10):1963–1973. https://doi.org/10.1016/j.jcmg.2021.03.026

Article  PubMed  PubMed Central  Google Scholar 

Axson EL, Sundaram V, Bloom CI, Bottle A, Cowie MR, Quint JK (2020) Temporal trends in the incidence of heart failure among patients with chronic obstructive pulmonary disease and its association with mortality. Ann ATS 17(8):939–948. https://doi.org/10.1513/AnnalsATS.201911-820OC

Article  Google Scholar 

Chen H, Luo X, Du Y et al (2023) Association between chronic obstructive pulmonary disease and cardiovascular disease in adults aged 40 years and above: data from NHANES 2013–2018. BMC Pulm Med 23(1):318. https://doi.org/10.1186/s12890-023-02606-1

Article  PubMed  PubMed Central  Google Scholar 

Kibbler J, Wade C, Mussell G, Ripley DP, Bourke SC, Steer J (2023) Systematic review and meta-analysis of prevalence of undiagnosed major cardiac comorbidities in COPD. ERJ Open Res 9(6):00548–02023. https://doi.org/10.1183/23120541.00548-2023

Article  PubMed  PubMed Central  Google Scholar 

Gulea C, Zakeri R, Quint JK (2022) Differences in outcomes between heart failure phenotypes in patients with coexistent chronic obstructive pulmonary disease: a cohort study. Ann Am Thorac Soc 19(6):971–980. https://doi.org/10.1513/AnnalsATS.202107-823OC

Article  PubMed  Google Scholar 

Axson EL, Ragutheeswaran K, Sundaram V et al (2020) Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis. Respir Res 21(1):54. https://doi.org/10.1186/s12931-020-1312-7

Article  PubMed  PubMed Central  Google Scholar 

Yang M, Kondo T, Adamson C et al (2023) Impact of comorbidities on health status measured using the Kansas City cardiomyopathy questionnaire in patients with heart failure with reduced and preserved ejection fraction. Eur J Heart Fail 25(9):1606–1618. https://doi.org/10.1002/ejhf.2962

Article  PubMed  CAS  Google Scholar 

Becher PM, Lindberg F, Benson L et al (2024) Phenotyping patients with chronic obstructive pulmonary disease and heart failure. ESC Heart Fail. https://doi.org/10.1002/ehf2.15127. (Published online November 7, 2024)

Article  PubMed  PubMed Central  Google Scholar 

Lau F, Schupp T, Schmitt A et al (2024) Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction. Respir Med 223:107536. https://doi.org/10.1016/j.rmed.2024.107536

Article  PubMed  Google Scholar 

Canepa M, Straburzynska-Migaj E, Drozdz J et al (2018) Characteristics, treatments and 1-year prognosis of hospitalized and ambulatory heart failure patients with chronic obstructive pulmonary disease in the European Society of Cardiology Heart Failure Long-Term Registry. Eur J Heart Fail 20(1):100–110. https://doi.org/10.1002/ejhf.964

Article  PubMed  CAS  Google Scholar 

Yeoh SE, Dewan P, Serenelli M et al (2022) Effects of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction patients with chronic obstructive pulmonary disease in EMPHASIS-HF and RALES. Eur J Heart Fail 24(3):529–538. https://doi.org/10.1002/ejhf.2350

Article  PubMed  CAS  Google Scholar 

Ehteshami-Afshar S, Mooney L, Dewan P et al (2021) Clinical characteristics and outcomes of patients with heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: insights from PARADIGM-HF. J Am Heart Assoc 10(4):e019238. https://doi.org/10.1161/JAHA.120.019238

Article  PubMed  PubMed Central  Google Scholar 

Dewan P, Docherty KF, Bengtsson O et al (2021) Effects of dapagliflozin in heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: an analysis of DAPA-HF. Eur J Heart Fail 23(4):632–643. https://doi.org/10.1002/ejhf.2083

Article  PubMed  CAS  Google Scholar 

Ramalho SHR, Claggett BL, Sweitzer NK et al (2020) Impact of pulmonary disease on the prognosis in heart failure with preserved ejection fraction: the TOPCAT trial. Eur J Heart Fail 22(3):557–559. https://doi.org/10.1002/ejhf.1593

Article  PubMed  Google Scholar 

Mooney L, Hawkins NM, Jhund PS et al (2021) Impact of chronic obstructive pulmonary disease in patients with heart failure with preserved ejection fraction: insights from PARAGON-HF. J Am Heart Assoc 10(23):e021494. https://doi.org/10.1161/JAHA.121.021494

Article  PubMed  PubMed Central  CAS  Google Scholar 

Butt JH, Lu H, Kondo T et al (2023) Heart failure, chronic obstructive pulmonary disease and efficacy and safety of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction: insights from DELIVER. Eur J Heart Fail 25(11):2078–2090. https://doi.org/10.1002/ejhf.3000

Article  PubMed  CAS  Google Scholar 

Von Haehling S, Butler J, Anker SD (2024) Effectiveness of empagliflozin in patients with heart failure and COPD: results from emperor-preserved and emperor-reduced. Eur Heart J 45(Supplement_1):ehae666.1171. https://doi.org/10.1093/eurheartj/ehae666.1171

Article  Google Scholar 

Xu S, Gu Z, Zhu W, Feng S (2024) Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction. ESC Heart Fail. https://doi.org/10.1002/ehf2.14958. (Published online July 12, 2024)

Article  PubMed  PubMed Central  Google Scholar 

Caravita S, Vachiéry JL (2016) Obstructive ventilatory disorder in heart failure—caused by the heart or the lung? Curr Heart Fail Rep 13(6):310–318. https://doi.org/10.1007/s11897-016-0309-5

Article  PubMed  Google Scholar 

Wetzel RC, Herold CJ, Zerhouni EA, Robotham JL (1993) Intravascular volume loading reversibly decreases airway cross-sectional area. Chest 103(3):865–870. https://doi.org/10.1378/chest.103.3.865

Article  PubMed  CAS  Google Scholar 

Orea-Tejeda A, Gómez-Martínez M, González-Islas D et al (2022) The impact of hydration status and fluid distribution on pulmonary function in COPD patients. Sci Rep 12(1):1216. https://doi.org/10.1038/s41598-022-05192-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Agostoni P, Bussotti M, Cattadori G et al (2006) Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J 27(21):2538–2543. https://doi.org/10.1093/eurheartj/ehl302

Article  PubMed  Google Scholar 

Magrì D, Brioschi M, Banfi C et al (2009) Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure. Circ Heart Fail 2(3):175–180. https://doi.org/10.1161/CIRCHEARTFAILURE.108.819607

Article  PubMed  CAS  Google Scholar 

Pezzuto B, Contini M, Berna G et al (2024) Dynamic trend of lung fluid movement during exercise in heart failure: from lung imaging to alveolar-capillary membrane function. Int J Cardiol 407:132041. https://doi.org/10.1016/j.ijcard.2024.132041

Article  PubMed  Google Scholar 

Malfatto G, Caravita S, Giglio A et al (2015) Pulmonary congestion at rest and abnormal ventilation during exercise in chronic systolic heart failure. J Am Heart Assoc 4(5):e001678. https://doi.org/10.1161/JAHA.114.001678

Article  PubMed  PubMed Central 

Comments (0)

No login
gif