Anwanwan D, Singh SK, Singh S, Saikam V, Singh R (2020) Challenges in liver cancer and possible treatment approaches. Biochimica et Biophysica Acta (BBA) - Rev Cancer 1873(1):188314. https://doi.org/10.1016/j.bbcan.2019.188314

Article  CAS  Google Scholar 

Gravitz L (2014) Liver cancer. Nature 516(7529):S1–S1. https://doi.org/10.1038/516S1a

Article  CAS  PubMed  Google Scholar 

Dubois B et al (2014) Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol 13(6):614–629. https://doi.org/10.1016/S1474-4422(14)70090-0

Article  PubMed  Google Scholar 

Li C, Götz EJ (2017) Tau-based therapies in neurodegeneration: opportunities and challenges. Nat Rev Drug Discov 16(12):863–883. https://doi.org/10.1038/nrd.2017.155

Article  CAS  PubMed  Google Scholar 

Chételat G (2018) Multimodal neuroimaging in Alzheimer’s disease: early diagnosis, physiopathological mechanisms, and impact of lifestyle. J Alzheimer’s Dis 64(s1):S199–S211. https://doi.org/10.3233/JAD-179920

Article  Google Scholar 

Sun B-L et al (2018) Clinical research on Alzheimer’s disease: progress and perspectives. Neurosci Bull 34(6):1111–1118. https://doi.org/10.1007/s12264-018-0249-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Shukla M, Wang W, Li S (2024) Unlocking gut-liver-brain axis communication metabolites: energy metabolism, immunity and barriers. NPJ Biofilms Microbiomes 10(1):136. https://doi.org/10.1038/s41522-024-00610-9

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Kim S, Seki E (2019) Inflammation and liver cancer: molecular mechanisms and therapeutic targets. Semin Liver Dis 39(01):026–042. https://doi.org/10.1055/s-0038-1676806

Article  CAS  Google Scholar 

Liu XL et al (2024) Past, present, and future of liver-brain axis in Alzheimer’s disease: a bibliometric review. J Alzheimer’s Dis 101(4):1267–1280. https://doi.org/10.3233/JAD-240688

Article  CAS  Google Scholar 

Butterworth RF (2011) Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 53(4):1372–1376. https://doi.org/10.1002/hep.24228

Article  PubMed  Google Scholar 

Fujikawa R, Tsuda M (2023) The functions and phenotypes of microglia in Alzheimer’s disease. Cells 12(8):1207. https://doi.org/10.3390/cells12081207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C et al (2023) The effects of microglia-associated neuroinflammation on Alzheimer’s disease. Front Immunol. https://doi.org/10.3389/fimmu.2023.1117172

Article  PubMed  PubMed Central  Google Scholar 

Yang X, Qiu K, Jiang Y, Huang Y, Zhang Y, Liao Y (2024) Metabolic crosstalk between liver and brain: from diseases to mechanisms. Int J Mol Sci 25(14):7621. https://doi.org/10.3390/ijms25147621

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paouri E, Georgopoulos S (2019) Systemic and CNS inflammation crosstalk: implications for Alzheimer’s disease. Curr Alzheimer Res 16(6):559–574. https://doi.org/10.2174/1567205016666190321154618

Article  CAS  PubMed  Google Scholar 

Wei X, Zhang L, Zeng Y (2020) DNA methylation in Alzheimer’s disease: in brain and peripheral blood. Mech Ageing Dev 191:111319. https://doi.org/10.1016/j.mad.2020.111319

Article  CAS  PubMed  Google Scholar 

Larsson SC, Butterworth AS, Burgess S (2023) Mendelian randomization for cardiovascular diseases: principles and applications. Eur Heart J 44(47):4913–4924. https://doi.org/10.1093/eurheartj/ehad736

Article  PubMed  PubMed Central  Google Scholar 

Pang W-W et al (2024) Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis. Front Immunol. https://doi.org/10.3389/fimmu.2024.1334479

Article  PubMed  PubMed Central  Google Scholar 

Davis AP et al (2021) Comparative toxicogenomics database (CTD): update 2021. Nucleic Acids Res 49(D1):D1138–D1143. https://doi.org/10.1093/nar/gkaa891

Article  CAS  PubMed  Google Scholar 

Safran M et al (2010) (2010) “GeneCards Version 3: the human gene integrator.” Database 2010:baq020–baq020. https://doi.org/10.1093/database/baq020

Article  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9(1):559. https://doi.org/10.1186/1471-2105-9-559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrett T et al (2012) Ncbi geo: archive for functional genomics data sets—update. Nucleic Acids Res 41(D1):D991–D995. https://doi.org/10.1093/nar/gks1193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523. https://doi.org/10.1038/s41467-019-09234-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou C-H et al (2018) miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. Nucleic Acids Res 46(D1):D296–D302. https://doi.org/10.1093/nar/gkx1067

Article  CAS  PubMed  Google Scholar 

Davies NM, Holmes MV, Davey Smith EG (2018) “Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians”. BMJ, k601. https://doi.org/10.1136/bmj.k601

Calsolaro V, Edison P (2016) Neuroinflammation in Alzheimer’s disease: current evidence and future directions. Alzheimer’s Dementia 12(6):719–732. https://doi.org/10.1016/j.jalz.2016.02.010

Article  PubMed  Google Scholar 

Schmidt-Arras D, Rose-John S (2016) IL-6 pathway in the liver: from physiopathology to therapy. J Hepatol 64(6):1403–1415. https://doi.org/10.1016/j.jhep.2016.02.004

Article  CAS  PubMed  Google Scholar 

Dhapola R, Hota SS, Sarma P, Bhattacharyya A, Medhi B, Reddy DH (2021) Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease. Inflammopharmacology 29(6):1669–1681. https://doi.org/10.1007/s10787-021-00889-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N (2010) A meta-analysis of cytokines in Alzheimer’s disease. Biol Psychiatry 68(10):930–941. https://doi.org/10.1016/j.biopsych.2010.06.012

Article  CAS  PubMed  Google Scholar 

Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073–1081. https://doi.org/10.1093/carcin/bgp127

Article  CAS  PubMed  Google Scholar 

Zhang C et al (2023) A novel NFAT1-IL6/JAK/STAT3 signaling pathway related nomogram predicts overall survival in gliomas. Sci Rep 13(1):11401. https://doi.org/10.1038/s41598-023-38629-1

Article  CAS