Borrego-Écija S, Montagut N, Martín-Trias P, Vaqué-Alcázar L, Illán-Gala I, Balasa M et al (2023) Multifocal Transcranial Direct Current Stimulation in Primary Progressive Aphasia Does Not Provide a Clinical Benefit Over Speech Therapy. J Alzheimers Dis 93:1169–1180. https://doi.org/10.3233/JAD-220388

Article  CAS  PubMed  Google Scholar 

Mesulam MM (1987) Primary progressive aphasia–differentiation from Alzheimer’s disease. Ann Neurol 22:533–534

CAS  PubMed  Google Scholar 

Norata D, Motolese F, Magliozzi A, Pilato F, Di Lazzaro V, Luzzi S et al (2023) Transcranial direct current stimulation in semantic variant of primary progressive aphasia: a state-of-the-art review. Front Hum Neurosci 17:1219737. https://doi.org/10.3389/fnhum.2023.1219737

Article  PubMed  PubMed Central  Google Scholar 

Cotelli M, Manenti R, Ferrari C, Gobbi E, Macis A, Cappa SF (2020) Effectiveness of language training and non-invasive brain stimulation on oral and written naming performance in Primary Progressive Aphasia: A meta-analysis and systematic review. Neurosci Biobehav Rev 108:498–525

PubMed  Google Scholar 

Fregni F, El-Hagrassy MM, Pacheco-Barrios K et al (2021) Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders. Int J Neuropsychopharmacol 24(4):256–313. https://doi.org/10.1093/ijnp/pyaa051

Article  PubMed  Google Scholar 

Lefaucheur JP, Antal A, Ayache SS et al (2017) Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol 128(1):56–92. https://doi.org/10.1016/j.clinph.2016.10.087

Article  PubMed  Google Scholar 

Bindman LJ, Lippold OC, Redfearn JW (1962) Long-lasting changes in the level of the electrical activity of the cerebral cortex produced bypolarizing currents. Nature 196:584–585

CAS  PubMed  Google Scholar 

Di Lazzaro V, Bella R, Benussi A, Bologna M, Borroni B, Capone F et al (2021) Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia. Clin Neurophysiol 132:2568–2607. https://doi.org/10.1016/j.clinph.2021.06.022

Article  PubMed  Google Scholar 

Bindman LJ, Lippold OCJ, Redfearn JWT (1964) The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J Physiol (London) 172:369–382

CAS  PubMed  Google Scholar 

Nissim NR, Moberg PJ, Hamilton RH (2020) Efficacy of noninvasive brain stimulation (tDCS or TMS) paired with language therapy in the treatment of primary progressive aphasia: An exploratory meta-analysis. Brain Sci 10(9):597. https://doi.org/10.3390/brainsci10090597

Article  PubMed  PubMed Central  Google Scholar 

Nissim NR, Harvey DY, Haslam C, Friedman L, Bharne P, Litz G et al (2022) Through Thick and Thin: Baseline Cortical Volume and Thickness Predict Performance and Response to Transcranial Direct Current Stimulation in Primary Progressive Aphasia. Front Hum Neurosci 16:907425. https://doi.org/10.3389/fnhum.2022.907425

Article  PubMed  PubMed Central  Google Scholar 

Roncero C, Kniefel H, Service E, Thiel A, Probst S, Chertkow H. (2017) Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer’s disease and frontotemporal dementia. Alzheimers Dement (N Y);3(2):247-253. https://doi.org/10.1016/j.trci.2017.03.003

Roncero C, Service E, De Caro M, Popov A, Thiel A, Probst S, et al. Maximizing the treatment benefit of tDCS in neurodegenerative anomia. Front Neurosci. 2019;13:1231. https://doi.org/10.3389/fnins.2019.

Gorman AL (1966) Differential patterns of activation of the pyramidal system elicited by surface anodal and cathodal cortical stimulation. J Neurophysiol 29:547–564

CAS  PubMed  Google Scholar 

Ardolino G, Bossi B, Barbieri S, Priori A (2005) Non-synaptic mechanisms underlie the after- effects of cathodal transcutaneous direct current stimulation of the human brain. J Physiol (London) 568:653–663

CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372. https://doi.org/10.1136/bmj.n71

Wechsler D (1981) WAIS-R Manual: Wechsler Adult Intelligence Scale-Revised. Psychological Corporation, New York

Google Scholar 

Snodgrass JG, Vanderwart M (1980) A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol Hum Learn 6:174–215

CAS  PubMed  Google Scholar 

Kertesz A (2006) Western aphasia battery-revised (WAB-R). Pro-Ed, Austin, TX

Bates E, Andonova E, D’Amico S, Jacobsen T, Kohnert K, Lu C et al (2000) Introducing the CRL international picture-naming project (CRL-IPNP). Center for Research in Language Newsletter 12:1–14

CAS  Google Scholar 

Lezak MD (2004) Neuropsychological Assessment. Oxford University Press, New York

Google Scholar 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2021) Cochrane handbook for systematic reviews of interventions version 6.4. Cochrane, London. https://training.cochrane.org/handbook. Accessed 8 Aug 2024

Sheppard SM, Goldberg EB, Sebastian R, Walker A, Meier EL, Hillis AE (2022) Transcranial Direct Current Stimulation Paired With Verb Network Strengthening Treatment Improves Verb Naming in Primary Progressive Aphasia: A Case Series. Am J Speech Lang Pathol 31(4):1736–1754. https://doi.org/10.1044/2022_AJSLP-21-00272

Article  PubMed  PubMed Central  Google Scholar 

Themistocleous C, Webster K, Tsapkini K (2021) Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia. Brain Sci 11:335. https://doi.org/10.3390/brainsci11030335

Article  PubMed  PubMed Central  Google Scholar 

Cotelli M, Manenti R, Petesi M, Brambilla M, Cosseddu M, Zanetti O et al (2014) Treatment of primary progressive aphasias by transcranial direct current stimulation combined with language training. J Alzheimers Dis 39:799–808. https://doi.org/10.3233/JAD-131108

Article  PubMed  Google Scholar 

Harris AD, Wang Z, Ficek B, Webster K, Edden RA, Tsapkini K (2019) Reductions in GABA following a tDCS-language intervention for primary progressive aphasia. Neurobiol Aging 79:75–82. https://doi.org/10.1016/j.neurobiolaging.2019.03.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neophytou K, Williamson K, Herrmann O, et al. Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study. Brain Sci. 2024;14(4):391. Published 2024 Apr 17. https://doi.org/10.3390/brainsci14040391

Wang Z, Ficek BN, Webster KT, Herrmann O, Frangakis CE, Desmond JE et al (2023) Specificity in Generalization Effects of Transcranial Direct Current Stimulation Over the Left Inferior Frontal Gyrus in Primary Progressive Aphasia. Neuromodulation 26:850–860. https://doi.org/10.1111/ner.13376

Article  PubMed  Google Scholar 

Teichmann M, Lesoil C, Godard J, Vernet M, Bertrand A, Levy R et al (2016) Direct current stimulation over the anterior temporal areas boosts semantic processing in primary progressive aphasia. Ann Neurol 80:693–707. https://doi.org/10.1002/ana.24774

Article  CAS  PubMed  Google Scholar 

Wechsler D. WAIS-IV: Wechsler Adult Intelligence Scale. San Antonio: Pearson; 2008.

ClinicalTrials.gov [Internet]. [cited 2024 Nov 1]. Available from: https://clinicaltrials.gov/study/NCT02928848?tab=results#outcome-measures

Byeon H (2020) Meta-Analysis on the Effects of Transcranial Direct Current Stimulation on Naming of Elderly with Primary Progressive Aphasia. Int J Environ Res Public Health 17: https://doi.org/10.3390/ijerph17031095

Chu CS, Li CT, Brunoni AR et al (2021) Cognitive effects and acceptability of non-invasive brain stimulation on Alzheimer’s disease and mild cognitive impairment: a component network meta-analysis. J Neurol Neurosurg Psychiatry 92(2):195–203. https://doi.org/10.1136/jnnp-2020-323870

Article  PubMed  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng H-Y, Corbett MS, Eldridge SM, Hernán MA, Hopewell S, Hróbjartsson A, Junqueira DR, Jüni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898

PubMed  Google Scholar 

Tang Y, Xing Y, Sun L, et al. TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer's Disease (TRANSFORM-AD): a randomized controlled clinical trial. Alzheimers Res Ther. 2024;16(1):203. Published 2024 Sep 12. https://doi.org/10.1186/s13195- 024–01570–0

Wang F, Wang Q, Wang L, et al. Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment. Front Aging Neurosci. 2022;14:814560. Published 2022 Feb 21. https://doi.org/10.3389/fnagi.2022.814560

Tsapkini K, Webster KT, Ficek BN (2018) The left inferior frontal gyrus tDCS enhances spelling skills in primary progressive aphasia. Front Hum Neurosci 12:70. https://doi.org/10.3389/fnhum.2018.00070

Article  Google Scholar 

ClinicalTrials.gov [Internet]. Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy. [cited 2024 Nov 12]. Available from: https://clinicaltrials.gov/study/NCT03728582

Friederici AD, Gierhan SME (2013) The language network. Curr Opin Neurobiol 23(2):250–254. https://doi.org/10.1016/j.conb.2012.10.002

Article  CAS  PubMed  Google Scholar 

Roncero C, Kniefel H, Service E, Thiel A, Probst S, Chertkow H (2017) Inferior parietal transcranial direct current stimulation with training improves cognition in anomic Alzheimer’s disease and frontotemporal dementia. Alzheimers Dement 3:247–253. https://doi.org/10.1016/j.trci.2017.01.003

Article  Google Scholar