Lamptey RNL, Chaulagain B, Trivedi R et al (2022) A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics. Int J Mol Sci. https://doi.org/10.3390/ijms23031851

Article  PubMed  PubMed Central  Google Scholar 

Chopade P, Chopade N, Zhao Z et al (2023) Alzheimer’s and parkinson’s disease therapies in the clinic. Bioeng Transl Med 8:e10367. https://doi.org/10.1002/btm2.10367

Article  PubMed  CAS  Google Scholar 

Goedert M, Spillantini MG, Del Tredici K, Braak H (2013) 100 years of lewy pathology. Nat Rev Neurol 9:13–24. https://doi.org/10.1038/nrneurol.2012.242

Article  PubMed  CAS  Google Scholar 

Palathoti JJB, Dhanasekaran N M, et al (2023) Neurotrophin mimetics and Tropomyosin kinase receptors: a futuristic Pharmacological tool for parkinson’s. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. https://doi.org/10.1007/s10072-023-06684-1

Kumar A, Sidhu J, Lui F, Tsao JW (2024) Alzheimer disease. Treasure Island (FL)

Dugger BN, Dickson DW (2017) Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol 9. https://doi.org/10.1101/cshperspect.a028035

Vacchi E, Kaelin-Lang A, Melli G (2020) Tau and alpha synuclein synergistic effect in neurodegenerative diseases: when the periphery is the core. Int J Mol Sci 21. https://doi.org/10.3390/ijms21145030

Picca A, Calvani R, Coelho-Junior HJ et al (2020) Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration. Antioxid (Basel Switzerland) 9. https://doi.org/10.3390/antiox9080647

Duka T, Duka V, Joyce JN, Sidhu A (2009) Alpha-synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in parkinson’s disease models. FASEB J 23:2820–2830. https://doi.org/10.1096/fj.08-120410

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang H, Wei W, Zhao M et al (2021) Interaction between Aβ and Tau in the Pathogenesis of Alzheimer’s Disease. Int J Biol Sci 17:2181–2192. https://doi.org/10.7150/ijbs.57078

Article  PubMed  PubMed Central  CAS  Google Scholar 

Giri M, Kendre PN, Bhalke R et al (2024) Chap. 26 - Combinatorial therapy in Alzheimer’s disease. In: Prajapati BG, Chellappan DK, Kendre PNBT-AD and ADDS (eds). Academic Press, pp 439–461

Badiola N, de Oliveira RM, Herrera F et al (2011) Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy. PLoS ONE 6:e26609. https://doi.org/10.1371/journal.pone.0026609

Padilla-Godínez FJ, Vázquez-García ER, Trujillo-Villagrán MI et al (2025) Α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies. Front Neurosci 19:1570553. https://doi.org/10.3389/fnins.2025.1570553

Article  PubMed  PubMed Central  Google Scholar 

Twohig D, Nielsen HM (2019) α-synuclein in the pathophysiology of alzheimer’s disease. Mol Neurodegener 14:23. https://doi.org/10.1186/s13024-019-0320-x

Article  PubMed  PubMed Central  Google Scholar 

Lu J, Zhang S, Ma X et al (2020) Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation. J Biol Chem 295:7470–7480. https://doi.org/10.1074/jbc.RA119.012284

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moussaud S, Jones DR, Moussaud-Lamodière EL et al (2014) Alpha-synuclein and tau: teammates in neurodegeneration? Mol Neurodegener 9:43. https://doi.org/10.1186/1750-1326-9-43

Article  PubMed  PubMed Central  Google Scholar 

Irwin DJ, Lee VM-Y, Trojanowski JQ (2013) Parkinson’s disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat Rev Neurosci 14:626–636. https://doi.org/10.1038/nrn3549

Article  PubMed  PubMed Central  CAS  Google Scholar 

Morales R, Moreno-Gonzalez I, Soto C (2013) Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases. PLoS Pathog 9:e1003537. https://doi.org/10.1371/journal.ppat.1003537

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vidović M, Rikalovic MG (2022) Alpha-Synuclein aggregation pathway in parkinson’s disease: current status and novel therapeutic approaches. https://doi.org/10.3390/cells11111732. Cells 11:

Van Den Berge N, Ferreira N, Gram H et al (2019) Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats. Acta Neuropathol 138:535–550. https://doi.org/10.1007/s00401-019-02040-w

Article  PubMed  CAS  Google Scholar 

Buerger K, Ewers M, Pirttilä T et al (2006) CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer’s disease. Brain 129:3035–3041. https://doi.org/10.1093/brain/awl269

Article  PubMed  Google Scholar 

Shah JV, Flanagan LA, Janmey PA, Leterrier J-F (2000) Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell 11:3495–3508. https://doi.org/10.1091/mbc.11.10.3495

Article  PubMed  PubMed Central  CAS  Google Scholar 

Manfredsson FP, Luk KC, Benskey MJ et al (2018) Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiol Dis 112:106–118. https://doi.org/10.1016/j.nbd.2018.01.008

Article  PubMed  PubMed Central  CAS  Google Scholar 

Allen Reish HE, Standaert DG (2015) Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. J Parkinsons Dis 5:1–19. https://doi.org/10.3233/JPD-140491

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahn EH, Kang SS, Liu X et al (2020) Initiation of Parkinson’s disease from gut to brain by δ-secretase. Cell Res 30:70–87. https://doi.org/10.1038/s41422-019-0241-9

Article  PubMed  Google Scholar 

Morgan MJ, Gamez G, Menke C et al (2014) Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy 10:1814–1826. https://doi.org/10.4161/auto.32135

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with Parkinson disease. J Neurol Sci 289:18–22. https://doi.org/10.1016/j.jns.2009.08.034

Article  PubMed  Google Scholar 

Whittaker HT, Qui Y, Bettencourt C, Houlden H (2017) Multiple system atrophy: genetic risks and alpha-synuclein mutations. https://doi.org/10.12688/f1000research.12193.1. F1000Research 6:2072

Kanaan NM, Manfredsson FP (2012) Loss of functional alpha-synuclein: a toxic event in parkinson’s disease? J Parkinsons Dis 2:249–267. https://doi.org/10.3233/JPD-012138

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nordengen K, Morland C (2024) From synaptic physiology to synaptic pathology: the enigma of α-Synuclein. Int J Mol Sci 25. https://doi.org/10.3390/ijms25020986

Stefanis L (2012) α-Synuclein in parkinson’s disease. Cold Spring Harb Perspect Med 2:a009399. https://doi.org/10.1101/cshperspect.a009399

Gholami A (2023) Alzheimer’s disease: the role of proteins in formation, mechanisms, and new therapeutic approaches. Neurosci Lett 817:137532. https://doi.org/10.1016/j.neulet.2023.137532

Article  PubMed  CAS  Google Scholar 

Guo T, Noble W, Hanger DP (2017) Roles of Tau protein in health and disease. Acta Neuropathol 133:665–704. https://doi.org/10.1007/s00401-017-1707-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mandelkow E-M, Mandelkow E (2012) Biochemistry and cell biology of Tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2:a006247. https://doi.org/10.1101/cshperspect.a006247

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bartošík V, Plucarová J, Laníková A et al (2024) Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways. J Biol Chem 300:107551. https://doi.org/10.1016/j.jbc.2024.107551

Shim KH, Kang MJ, Youn YC et al (2022) Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease. Alzheimers Res Ther 14:201.https://doi.org/10.1186/s13195-022-01150-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Spires-Jones TL, Attems J, Thal DR (2017) Interactions of pathological proteins in neurodegenerative diseases. Acta Neuropathol 134:187–205.