Bifidobacteria in antibiotic-associated dysbiosis: restoring balance in the gut microbiome

Afzaal M, Saeed F, Shah YA, Hussain M, Rabail R, Socol CT, Hassoun A, Pateiro M, Lorenzo JM, Rusu AV, Aadil RM (2022) Human gut microbiota in health and disease: unveiling the relationship. Front Microbiol 13:999001. https://doi.org/10.3389/fmicb.2022.999001

Article  PubMed  PubMed Central  Google Scholar 

Alessandri G, van Sinderen D, Ventura M (2021) The genus bifidobacterium: from genomics to functionality of an important component of the mammalian gut microbiota running title: bifidobacterial adaptation to and interaction with the host. Comput Struct Biotechnol J 19:1472–1487. https://doi.org/10.1016/j.csbj.2021.03.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allegretti JR, Kearney S, Li N, Bogart E, Bullock K, Gerber GK, Bry L, Clish CB, Alm E, Korzenik JR (2016) Recurrent Clostridium difficile infection associates with distinct bile acid and Microbiome profiles. Aliment Pharmacol Ther 43:1142–1153. https://doi.org/10.1111/apt.13616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen SJ, Wareham K, Bradley C, Harris W, Dhar A, Brown H, Foden A, Cheung WY, Gravenor MB, Plummer S, Phillips CJ, Mack D (2012) A multicentre randomised controlled trial evaluating lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea in older people admitted to hospital: the PLACIDE study protocol. BMC Infect Dis 12:108. https://doi.org/10.1186/1471-2334-12-108

Article  PubMed  PubMed Central  Google Scholar 

Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W, Dhar A, Brown H, Foden A, Gravenor MB, Mack D (2013) Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 382:1249–1257. https://doi.org/10.1016/S0140-6736(13)61218-0

Article  PubMed  Google Scholar 

Anthony WE, Wang B, Sukhum KV, D’Souza AW, Hink T, Cass C, Seiler S, Reske KA, Coon C, Dubberke ER, Burnham CD, Dantas G, Kwon JH (2022) Acute and persistent effects of commonly used antibiotics on the gut Microbiome and resistome in healthy adults. Cell Rep 39:110649. https://doi.org/10.1016/j.celrep.2022.110649

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arboleya S, Watkins C, Stanton C, Ross RP (2016) Gut bifidobacteria populations in human health and aging. Front Microbiol 7:1204. https://doi.org/10.3389/fmicb.2016.01204

Article  PubMed  PubMed Central  Google Scholar 

Balsells E, Shi T, Leese C, Lyell I, Burrows J, Wiuff C, Campbell H, Kyaw MH, Nair H (2019) Global burden of Clostridium difficile infections: a systematic review and meta-analysis. J Glob Health 9:010407. https://doi.org/10.7189/jogh.09.010407

Article  PubMed  Google Scholar 

Barker AK, Duster M, Valentine S, Hess T, Archbald-Pannone L, Guerrant R, Safdar N (2017) A randomized controlled trial of probiotics for Clostridium difficile infection in adults (PICO). J Antimicrob Chemother 72:3177–3180. https://doi.org/10.1093/jac/dkx254

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baumler AJ, Sperandio V (2016) Interactions between the microbiota and pathogenic bacteria in the gut. Nature 535:85–93. https://doi.org/10.1038/nature18849

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bejaoui S, Poulsen M (2020) The impact of early life antibiotic use on atopic and metabolic disorders: Meta-analyses of recent insights. Evol Med Public Health 24:279–289. https://doi.org/10.1093/emph/eoaa039

Google Scholar 

Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G, Davies R, Al Khatib H, Bonnett C, Ganesh S, Bakker E, Hart D, Mangino M, Merino J, Linenberg I, Wyatt P, Ordovas JM, Gardner CD, Delahanty LM, Chan AT, Segata N, Franks PW, Spector TD (2020) Human postprandial responses to food and potential for precision nutrition. Nat Med 26:964–973. https://doi.org/10.1038/s41591-020-0934-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhalodi AA, van Engelen TSR, Virk HS, Wiersinga WJ (2019) Impact of antimicrobial therapy on the gut Microbiome. J Antimicrob Chemother 74:i6–i15. https://doi.org/10.1093/jac/dky530

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blaser MJ (2016) Antibiotic use and its consequences for the normal Microbiome. Science 352:544–545. https://doi.org/10.1126/science.aad9358

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bubnov R, Babenko L, Lazarenko L, Kryvtsova M, Shcherbakov O, Zholobak N, Golubnitschaja O, Spivak M (2019) Can tailored nanoceria act as a prebiotic? Report on improved lipid profile and gut microbiota in obese mice. EPMA J 10:317–335. https://doi.org/10.1007/s13167-019-00190-1

Article  PubMed  PubMed Central  Google Scholar 

Campbell C, Kandalgaonkar MR, Golonka RM, Yeoh BS, Vijay-Kumar M, Saha P (2023) Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy. https://doi.org/10.3390/biomedicines11020294. Biomedicines 11

Centanni M, Lawley B, Butts CA, Roy NCLee J, Kelly WJ, Tannock GW (2018) Bifidobacterium pseudolongum in the Ceca of rats fed hi-maize starch has characteristics of a keystone species in bifidobacterial blooms. Appl Environ Microbiol 84:e00547–e00518. https://doi.org/10.1128/AEM.00547-18

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandra H, Sharma KK, Tuovinen OH, Sun X, Shukla P (2021) Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on clostridioides difficile. Gut Microbes 13:1979882. https://doi.org/10.1080/19490976.2021.1979882

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M (2013) Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea. J Assoc Physicians India 61:708–712

PubMed  Google Scholar 

Chenoll E, Casinos B, Bataller E, Astals P, Echevarria J, Iglesias JR, Balbarie P, Ramon D, Genoves S (2011) Novel probiotic Bifidobacterium bifidum CECT 7366 strain active against the pathogenic bacterium Helicobacter pylori. Appl Environ Microbiol 77:1335–1343. https://doi.org/10.1128/AEM.01820-10

Article  CAS  PubMed  Google Scholar 

Chiang JYL, Ferrell JM (2020) Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy. Am J Physiol Gastrointest Liver Physiol 318:G554–G573. https://doi.org/10.1152/ajpgi.00223.2019

Article  PubMed  PubMed Central  Google Scholar 

Choi MH, Kim D, Lee KH, Kim HJ, Sul WJ, Jeong SH (2024) Dysbiosis of the gut microbiota is associated with in-hospital mortality in patients with antibiotic-associated diarrhoea: A metagenomic analysis. Int J Antimicrob Agents 64:107330. https://doi.org/10.1016/j.ijantimicag.2024.107330

Article  CAS  PubMed  Google Scholar 

Correa NB, Peret Filho LA, Penna FJ, Lima FM, Nicoli JR (2005) A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol 39:385–389. https://doi.org/10.1097/01.mcg.0000159217.47419.5b

Article  PubMed  Google Scholar 

Cusumano G, Flores GA, Venanzoni R, Angelini P (2025) The impact of antibiotic therapy on intestinal microbiota: dysbiosis, antibiotic resistance, and restoration strategies. Antibiot (Basel) 14. https://doi.org/10.3390/antibiotics14040371

Dahiya D, Nigam PS (2023) Antibiotic-therapy-induced gut dysbiosis affecting gut microbiota-brain axis and cognition: restoration by intake of probiotics and synbiotics. Int J Mol Sci 24. https://doi.org/10.3390/ijms24043074

Dang Y, Reinhardt JD, Zhou X, Zhang G (2014) The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: a meta-analysis. PLoS ONE 9:e111030. https://doi.org/10.1371/journal.pone.0111030

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Vrese M, Kristen H, Rautenberg P, Laue C, Schrezenmeir J (2011) Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit Preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res 78:396–403. https://doi.org/10.1017/S002202991100063X

Article  CAS  PubMed  Google Scholar 

De Wolfe TJ, Eggers S, Barker AK, Kates AE, Dill-McFarland KA, Suen G, Safdar N (2018) Oral probiotic combination of Lactobacillus and Bifidobacterium alters the Gastrointestinal microbiota during antibiotic treatment for Clostridium difficile infection. PLoS ONE 13:e0204253. https://doi.org/10.1371/journal.pone.0204253

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif