Are Altered Knee Joint Biomechanics Associated with Future Post-Traumatic Osteoarthritis Outcomes? A Systematic Review and Meta-Analysis of Longitudinal Studies

Culvenor AG, Cook JL, Collins NJ, et al. Is patellofemoral joint osteoarthritis an under-recognised outcome of anterior cruciate ligament reconstruction? A narrative literature review. Br J Sports Med. 2013;47(2):66–70. https://doi.org/10.1136/bjsports-2012-091490.

Article  PubMed  Google Scholar 

Lie MM, Risberg MA, Storheim K, et al. What’s the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review. Br J Sports Med. 2019;53(18):1162–7. https://doi.org/10.1136/bjsports-2018-099751.

Article  PubMed  Google Scholar 

Filbay SR, Skou ST, Bullock GS, et al. Long-term quality of life, work limitation, physical activity, economic cost and disease burden following ACL and meniscal injury: a systematic review and meta-analysis for the OPTIKNEE consensus. Br J Sports Med. 2022;56(24):1465–74. https://doi.org/10.1136/bjsports-2022-105626.

Article  PubMed  Google Scholar 

Papandony MC, Chou L, Seneviwickrama M, et al. Patients’ perceived health service needs for osteoarthritis (OA) care: a scoping systematic review. Osteoarthr Cartil. 2017;25(7):1010–25. https://doi.org/10.1016/j.joca.2017.02.799.

Article  CAS  Google Scholar 

Duong V, Oo WM, Ding C, et al. Evaluation and treatment of knee pain: a review. JAMA. 2023;330(16):1568–80. https://doi.org/10.1001/jama.2023.19675.

Article  PubMed  CAS  Google Scholar 

Evers BJ, Van Den Bosch MHJ, Blom AB, et al. Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression. Front Med (Lausanne). 2022;9: 973870. https://doi.org/10.3389/fmed.2022.973870.

Article  PubMed  Google Scholar 

Andriacchi TP, Favre J. The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis. Curr Rheumatol Rep. 2014;16(11):463. https://doi.org/10.1007/s11926-014-0463-2.

Article  PubMed  Google Scholar 

Culvenor AG, Perraton L, Guermazi A, et al. Knee kinematics and kinetics are associated with early patellofemoral osteoarthritis following anterior cruciate ligament reconstruction. Osteoarthr Cartil. 2016;24(9):1548–53. https://doi.org/10.1016/j.joca.2016.05.010.

Article  CAS  Google Scholar 

Abram SGF, Price AJ, Judge A, et al. Anterior cruciate ligament (ACL) reconstruction and meniscal repair rates have both increased in the past 20 years in England: hospital statistics from 1997 to 2017. Br J Sports Med. 2020;54(5):286–91. https://doi.org/10.1136/bjsports-2018-100195.

Article  PubMed  Google Scholar 

Zbrojkiewicz D, Vertullo C, Grayson JE. Increasing rates of anterior cruciate ligament reconstruction in young Australians, 2000–2015. Med J Aust. 2018;208(8):354–8. https://doi.org/10.5694/mja17.00974.

Article  PubMed  Google Scholar 

Filbay SR, Roos EM, Frobell RB, et al. Delaying ACL reconstruction and treating with exercise therapy alone may alter prognostic factors for 5-year outcome: an exploratory analysis of the KANON trial. Br J Sports Med. 2017;51(22):1622–9. https://doi.org/10.1136/bjsports-2016-097124.

Article  PubMed  Google Scholar 

D’Souza N, Charlton J, Grayson J, et al. Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis. Osteoarthr Cartil. 2022;30(3):381–94. https://doi.org/10.1016/j.joca.2021.10.010.

Article  CAS  Google Scholar 

Hutchison L, Grayson J, Hiller C, et al. Relationship between knee biomechanics and pain in people with knee osteoarthritis: a systematic review and meta-analysis. Arthritis Care Res. 2023;75(6):1351–61. https://doi.org/10.1002/acr.25001.

Article  Google Scholar 

Mills K, Hunt MA, Ferber R. Biomechanical deviations during level walking associated with knee osteoarthritis: a systematic review and meta-analysis. Arthritis Care Res. 2013;65(10):1643–65. https://doi.org/10.1002/acr.22015.

Article  Google Scholar 

Teoli A, Cloutier-Gendron M, Ho SYK, et al. The relationship between knee loading during gait and cartilage thickness in nontraumatic and posttraumatic knee osteoarthritis. J Orthop Res. 2022;40(8):1778–86. https://doi.org/10.1002/jor.25219.

Article  PubMed  Google Scholar 

Robbins SM, Pelletier J-P, Abram F, et al. Gait risk factors for disease progression differ between non-traumatic and post-traumatic knee osteoarthritis. Osteoarthr Cartil. 2021;29(11):1487–97. https://doi.org/10.1016/j.joca.2021.07.014.

Article  CAS  Google Scholar 

Pfeiffer SJ, Spang J, Nissman D, et al. Gait mechanics and T1ρ MRI of tibiofemoral cartilage 6 months after ACL reconstruction. Med Sci Sports Exerc. 2019;51(4):630–9. https://doi.org/10.1249/MSS.0000000000001834.

Article  PubMed  CAS  Google Scholar 

Pietrosimone B, Loeser RF, Blackburn JT, et al. Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction. J Orthop Res. 2017;35(10):2288–97. https://doi.org/10.1002/jor.23534.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bjornsen E, Berkoff D, Blackburn JT, et al. Sustained limb-level loading: a ground reaction force phenotype common to individuals at high risk for and those with knee osteoarthritis. Arthritis Rheumatol. 2024;76(4):566–76. https://doi.org/10.1002/art.42744.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Titchenal MR, Williams AA, Chehab EF, et al. Cartilage subsurface changes to magnetic resonance imaging UTE-T2* 2 years after anterior cruciate ligament reconstruction correlate with walking mechanics associated with knee osteoarthritis. Am J Sports Med. 2018;46(3):565–72. https://doi.org/10.1177/0363546517743969.

Article  PubMed  PubMed Central  Google Scholar 

Williams AA, Titchenal MR, Andriacchi TP, et al. MRI UTE-T2* profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction. Osteoarthr Cartil. 2018;26(4):569–79. https://doi.org/10.1016/j.joca.2018.01.012.

Article  CAS  Google Scholar 

Whittaker JL, Culvenor AG, Juhl CB, et al. OPTIKNEE 2022: consensus recommendations to optimise knee health after traumatic knee injury to prevent osteoarthritis. Br J Sports Med. 2022;56(24):1393–405. https://doi.org/10.1136/bjsports-2022-106299.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, The PRISMA, et al. statement: an updated guideline for reporting systematic reviews. BMJ. 2020;2021: n71. https://doi.org/10.1136/bmj.n71.

Article  Google Scholar 

Culvenor AG, Oiestad BE, Hart HF, et al. Prevalence of knee osteoarthritis features on magnetic resonance imaging in asymptomatic uninjured adults: a systematic review and meta-analysis. Br J Sports Med. 2019;53(20):1268–78. https://doi.org/10.1136/bjsports-2018-099257.

Article  PubMed  Google Scholar 

Hayden JA, Van Der Windt DA, Cartwright JL, et al. Assessing bias in studies of prognostic factors. Ann Internal Med. 2013;158(4):280. https://doi.org/10.7326/0003-4819-158-4-201302190-00009.

Article  Google Scholar 

Higgins JPT, Thomas CJ, Cumpston M, et al. Cochrane handbook for systematic reviews of interventions version 6.4 (updated August 2023). 2023. Available from: www.training.cochrane.org/handbook. Accessed 26 Jul 2025.

Cohen J. Statistical power analysis for the behavioural sciences. Hillsdale (NJ): Routledge; 1988. https://doi.org/10.4324/9780203771587.

Article  Google Scholar 

RStudio Team U. RStudio: integrated development for R. Boston (MA): RStudio, PBC; 2020.

Capin JJ, Williams JR, Neal K, et al. Slower walking speed is related to early femoral trochlear cartilage degradation after ACL reconstruction. J Orthop Res. 2020;38(3):645–52. https://doi.org/10.1002/jor.24503.

Article  PubMed  Google Scholar 

Erhart-Hledik J, Chu C, Asay J, et al. Longitudinal changes in the total knee joint moment after anterior cruciate ligament reconstruction correlate with cartilage thickness changes. J Orthopaed Res. 2019;37(7):1546–54. https://doi.org/10.1002/jor.24295.

Article  Google Scholar 

Evans-Pickett A, Lisee C, Horton WZ, et al. Worse tibiofemoral cartilage composition is associated with insufficient gait kinetics after ACL reconstruction. Med Sci Sports Exerc. 2022;54(10):1771–81. https://doi.org/10.1249/MSS.0000000000002969.

Article  PubMed  CAS  Google Scholar 

Hall M, Wrigley TV, Metcalf BR, et al. Do moments and strength predict cartilage changes after partial meniscectomy? Med Sci Sports Exerc. 2015;47(8):1549–56. https://doi.org/10.1249/MSS.0000000000000575.

Article  PubMed  Google Scholar 

Kumar D, Su F, Wu D, et al. Frontal plane knee mechanics and early cartilage degeneration in people with anterior cruciate ligament reconstruction: a longitudinal study. Am J Sports Med. 2018;46(2):378–87. https://doi.org/10.1177/0363546517739605.

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