Immune-sparing potential of isocentric lateral decubitus positioning in adjuvant whole-breast radiotherapy

Xu C, Jin JY, Zhang M, Liu A, Wang J, Mohan R et al (2020) The impact of the effective dose to immune cells on lymphopenia and survival of esophageal cancer after chemoradiotherapy. Radiother Oncol 146:180–186

CAS  PubMed  PubMed Central  Google Scholar 

Yu Y, Fu P, Jin JY, Gao S, Wang W, Machtay M et al (2021) Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC. Radiother Oncol 162:26–33

PubMed  Google Scholar 

Grassberger C, Shinnick D, Yeap BY, Tracy M, Ellsworth SG, Hess CB et al (2021) Circulating lymphocyte counts early during radiation therapy are associated with recurrence in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys 110(4):1044–1052

PubMed  PubMed Central  Google Scholar 

Leon-Ferre RA, Jonas SF, Salgado R, Loi S, de Jong V, Carter JM et al (2024) Tumor-infiltrating lymphocytes in triple-negative breast cancer. JAMA 331(13):1135–1144

CAS  PubMed  PubMed Central  Google Scholar 

Liu F, Hardiman T, Wu K, Quist J, Gazinska P, Ng T et al (2021) Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication. Npj Breast Cancer 7:86

PubMed  PubMed Central  Google Scholar 

Imber BS, Chau KW, Lee J, Lee J, Casey DL, Yang JC et al (2021) Excellent response to very-low-dose radiation (4 Gy) for indolent B‑cell lymphomas: is 4 Gy suitable for curable patients? Blood Adv 5(20):4185–4197

PubMed  PubMed Central  Google Scholar 

Chao C, Wong SL, Woo C, Edwards MJ, Tuttle T, Noyes RD et al (2001) Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast. Am J Surg 182(4):307–311

CAS  PubMed  Google Scholar 

Loap P, Vu-Bezin J, De Marzi L, Kirova Y (2024) Proton therapy reduces the effective dose to immune cells in breast cancer patients. Strahlenther Onkol 200(12):1074–1079

PubMed  Google Scholar 

Loap P, Bezin VJ, De Marzi L, Kirova Y (2025) Determinants of radiation dose to immune cells during breast radiotherapy. Strahlenther Onkol 201(2):106–114

PubMed  Google Scholar 

Kirova YM, Hijal T, Campana F, Fournier-Bidoz N, Stilhart A, Dendale R et al (2014) Whole breast radiotherapy in the lateral decubitus position: a dosimetric and clinical solution to decrease the doses to the organs at risk (OAR). Radiother Oncol 110(3):477–481

PubMed  Google Scholar 

Loap P, Bezin VJ, Fourquet A, Kirova Y (2025) Heart and lung sparing with isocentric lateral decubitus positioning compared with dorsal decubitus positioning during adjuvant localized breast cancer radiotherapy. Br J Radiol. https://doi.org/10.1093/bjr/tqaf049

Article  PubMed  Google Scholar 

Campana F, Kirova YM, Rosenwald JC, Dendale R, Vilcoq JR, Dreyfus H et al (2005) Breast radiotherapy in the lateral decubitus position: a technique to prevent lung and heart irradiation. Int J Radiat Oncol Biol Phys 61(5):1348–1354

PubMed  Google Scholar 

Krhili S, Costa E, Xu HP, Kirova YM (2019) Whole breast radiotherapy in the isocentric lateral decubitus position: role of the immobilization device and table on clinical results. Cancer Radiother 23(3):209–215

CAS  PubMed  Google Scholar 

Offersen BV, Boersma LJ, Kirkove C, Hol S, Aznar MC, Sola AB et al (2015) ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol 114(1):3–10

PubMed  Google Scholar 

Msika R, Fourquet A, Laki F, Porte B, Servois V, Kirova Y (2020) Institut Curie guidelines on breast target volume delineation for patients treated in lateral position. Cancer Radiother 24(8):795–798

CAS  PubMed  Google Scholar 

Vescovi JD, Zimmerman SL, Miller WC, Hildebrandt L, Hammer RL, Fernhall B (2001) Evaluation of the BOD POD for estimating percentage body fat in a heterogeneous group of adult humans. Eur J Appl Physiol 85(3):326–332

CAS  PubMed  Google Scholar 

Holland R, Veling SH, Mravunac M, Hendriks JH (1985) Histologic multifocality of Tis, T1–2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56(5):979–990

CAS  PubMed  Google Scholar 

Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N et al (2014) Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 384(9938):164–172

PubMed  Google Scholar 

Pusztai L, Denkert C, O’Shaughnessy J, Cortes J, Dent R, McArthur H et al (2024) Event-free survival by residual cancer burden with pembrolizumab in early-stage TNBC: exploratory analysis from KEYNOTE-522. Ann Oncol 35(5):429–436

CAS  PubMed  Google Scholar 

Pons-Tostivint E, Alouani E, Kirova Y, Dalenc F, Vaysse C (2021) Is there a role for locoregional treatment of the primary tumor in de novo metastatic breast cancer in the era of tailored therapies?: Evidences, unresolved questions and a practical algorithm. Crit Rev Oncol Hematol 157:103146

CAS  PubMed  Google Scholar 

Herrera FG, Ronet C, Ochoa de Olza M, Barras D, Crespo I, Andreatta M et al (2022) Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy. Cancer Discov 12(1):108–133

CAS  PubMed  Google Scholar 

Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y et al (2016) Fulminant myocarditis with combination immune checkpoint blockade. N Engl J Med 375(18):1749–1755

PubMed  PubMed Central  Google Scholar 

Mahmood SS, Fradley MG, Cohen JV, Nohria A, Reynolds KL, Heinzerling LM et al (2018) Myocarditis in patients treated with immune checkpoint inhibitors. J Am Coll Cardiol 71(16):1755–1764

CAS  PubMed  PubMed Central  Google Scholar 

Loap P, Kirova Y (2023) In regard to Alcorn et al. Int J Radiat Oncol Biol Phys 116(2):469–470

PubMed  Google Scholar 

Reimer T, Stachs A, Veselinovic K, Kühn T, Heil J, Polata S et al (2025) Axillary surgery in breast cancer—primary results of the INSEMA trial. N Engl J Med 392(11):1051–1064

PubMed  Google Scholar 

Gentilini OD, Botteri E, Sangalli C, Galimberti V, Porpiglia M, Agresti R et al (2023) Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND randomized clinical trial. JAMA Oncol 9(11):1557–1564

PubMed  PubMed Central  Google Scholar 

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