Diabetes and longitudinal changes in deep learning–derived measures of vertebral bone mineral density using conventional CT: the Multi-Ethnic Study of Atherosclerosis

Wang H, Ba Y, Xing Q, Du J-L. Diabetes mellitus and the risk of fractures at specific sites: a meta-analysis. BMJ Open. 2019;9:e024067.

PubMed  PubMed Central  Google Scholar 

Miao J, Brismar K, Nyrén O, Ugarph-Morawski A, Ye W. Elevated hip fracture risk in type 1 diabetic patients: a population-based cohort study in Sweden. Diabetes Care. 2005;28:2850–5.

PubMed  Google Scholar 

Holloway-Kew KL, Marijanovic N, De Abreu LLF, Sajjad MA, Pasco JA, Kotowicz MA. Bone mineral density in diabetes and impaired fasting glucose. Osteoporos Int. 2019;30:1799–806.

CAS  PubMed  Google Scholar 

Holloway KL, De Abreu LLF, Hans D, Kotowicz MA, Sajjad MA, Hyde NK, et al. Trabecular bone score in men and women with impaired fasting glucose and diabetes. Calcif Tissue Int. 2018;102:32–40.

CAS  PubMed  Google Scholar 

Oei L, Zillikens MC, Dehghan A, Buitendijk GHS, Castaño-Betancourt MC, Estrada K, et al. High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study. Diabetes Care. 2013;36:1619–28.

CAS  PubMed  PubMed Central  Google Scholar 

Davie GS, Pal K, Orton E, Tyrrell EG, Petersen I. Incident type 2 diabetes and risk of fracture: a comparative cohort analysis using U.K. primary care records. Diabetes Care. 2021;44:58–66.

PubMed  Google Scholar 

Kindler JM, Kelly A, Khoury PR, Levitt Katz LE, Urbina EM, Zemel BS. Bone mass and density in youth with type 2 diabetes, obesity, and healthy weight. Diabetes Care. 2020;43:2544–52.

CAS  PubMed  PubMed Central  Google Scholar 

Hunt HB, Miller NA, Hemmerling KJ, Koga M, Lopez KA, Taylor EA, et al. Bone tissue composition in postmenopausal women varies with glycemic control from normal glucose tolerance to type 2 diabetes mellitus. J Bone Miner Res. 2021;36:334–46.

CAS  PubMed  Google Scholar 

American Diabetes Association Professional Practice Committee. 4. Comprehensive medical evaluation and assessment of comorbidities: standards of care in diabetes-2025. Diabetes Care. 2025;48:S59–85.

Guo L, Gao Z, Ge H. Effects of serum 25-hydroxyvitaminD level on decreased bone mineral density at femoral neck and total hip in Chinese type 2 diabetes. PLoS ONE. 2017;12:e0188894.

PubMed  PubMed Central  Google Scholar 

Rasmussen NH-H, Dal J, Kvist AV, van den Bergh JP, Jensen MH, Vestergaard P. Bone parameters in T1D and T2D assessed by DXA and HR-pQCT - a cross-sectional study: the DIAFALL study. Bone. 2023;172:116753.

Schwartz AV, Ewing SK, Porzig AM, McCulloch CE, Resnick HE, Hillier TA, et al. Diabetes and change in bone mineral density at the hip, calcaneus, spine, and radius in older women. Front Endocrinol (Lausanne). 2013;4:62.

PubMed  PubMed Central  Google Scholar 

Tramontana F, Napoli N, Litwack-Harrison S, Bauer DC, Orwoll ES, Cauley JA, et al. More rapid bone mineral density loss in older men with diabetes: the osteoporotic fractures in men (MrOS) study. J Clin Endocrinol Metab. 2024;109:e2283–90.

CAS  PubMed  PubMed Central  Google Scholar 

Gal-Moscovici A, Sprague SM. Osteoporosis and chronic kidney disease. Semin Dial. 2007;20:423–30.

PubMed  Google Scholar 

Moseley KF. Type 2 diabetes and bone fractures. Curr Opin Endocrinol Diabetes Obes. 2012;19:128–35.

CAS  PubMed  PubMed Central  Google Scholar 

Lipkin EW, Schwartz AV, Anderson AM, Davis C, Johnson KC, Gregg EW, et al. The look AHEAD trial: bone loss at 4-year follow-up in type 2 diabetes. Diabetes Care. 2014;37:2822–9.

CAS  PubMed  PubMed Central  Google Scholar 

Bilha SC, Leustean L, Preda C, Branisteanu DD, Mihalache L, Ungureanu M-C. Bone mineral density predictors in long-standing type 1 and type 2 diabetes mellitus. BMC Endocr Disord. 2021;21:156.

CAS  PubMed  PubMed Central  Google Scholar 

Jitraknatee J, Ruengorn C, Nochaiwong S. Prevalence and risk factors of chronic kidney disease among type 2 diabetes patients: a cross-sectional study in primary care practice. Sci Rep. 2020;10:6205.

CAS  PubMed  PubMed Central  Google Scholar 

de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, et al. Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2022;102:974–89.

PubMed  Google Scholar 

Hathaway QA, Kasaeian A, Pan T, Bluemke DA, Ghotbi E, Klein JG, et al. A deep learning model for three-dimensional determination of whole thoracic vertebral bone mineral density from noncontrast chest CT: The Multi-Ethnic Study of Atherosclerosis. Radiology [Internet]. 2025 [cited 2025 Mar 20];314. Available from: https://pubmed.ncbi.nlm.nih.gov/40067103/. Accessed 20 Mar 2025.

MESA overview and protocol. https://www.mesa-nhlbi.org/aboutMESAOverviewProtocol.aspx. Accessed 20 Mar 2025.

Wang M, Aaron CP, Madrigano J, Hoffman EA, Angelini E, Yang J, et al. Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function. JAMA [Internet]. 2019 [cited 2025 Mar 31];322:546–56. Available from: https://pubmed.ncbi.nlm.nih.gov/31408135/. Accessed 31 Mar 2025.

Bancks MP, Carnethon M, Chen H, Cotch MF, Klein B, Klein R, et al. Diabetes subgroups and risk for complications: the Multi-Ethnic Study of Atherosclerosis (MESA). J Diabetes Complications. 2021;35:107915.

CAS  PubMed  PubMed Central  Google Scholar 

Genuth S, Alberti KGMM, Bennett P, Buse J, Defronzo R, Kahn R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26:3160–7.

PubMed  Google Scholar 

American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care. 2003;26(Suppl 1):S33-50.

Google Scholar 

Sieren JP, Newell JD, Barr RG, Bleecker ER, Burnette N, Carretta EE, et al. SPIROMICS protocol for multicenter quantitative computed tomography to phenotype the lungs. Am J Respir Crit Care Med [Internet]. 2016 [cited 2025 Mar 31];194:794–806. Available from: https://pubmed.ncbi.nlm.nih.gov/27482984/. Accessed 31 Mar 2025.

Motahari A, Barr RG, Han MLK, Anderson WH, Barjaktarevic I, Bleecker ER, et al. Repeatability of pulmonary quantitative computed tomography measurements in chronic obstructive pulmonary disease. Am J Respir Crit Care Med [Internet]. 2023 [cited 2025 Mar 31];208:657–66. Available from: https://pubmed.ncbi.nlm.nih.gov/37490608/. Accessed 31 Mar 2025.

Wasserthal J, Breit H-C, Meyer MT, Pradella M, Hinck D, Sauter AW, et al. TotalSegmentator: robust segmentation of 104 anatomic structures in CT images. Radiol Artif Intell. 2023;5:e230024.

PubMed  PubMed Central  Google Scholar 

Buenger F, Sakr Y, Eckardt N, Senft C, Schwarz F. Correlation of quantitative computed tomography derived bone density values with Hounsfield units of a contrast medium computed tomography in 98 thoraco-lumbar vertebral bodies. Arch Orthop Trauma Surg. 2022;142:3335–40.

PubMed  Google Scholar 

Buenger F, Eckardt N, Sakr Y, Senft C, Schwarz F. Correlation of bone density values of quantitative computed tomography and Hounsfield units measured in native computed tomography in 902 vertebral bodies. World Neurosurg. 2021;151:e599-606.

PubMed  Google Scholar 

Farr JN, Khosla S. Determinants of bone strength and quality in diabetes mellitus in humans. Bone. 2016;82:28–34.

CAS  PubMed  Google Scholar 

Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, et al. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013;28:313–24.

PubMed  Google Scholar 

McCabe C, Sauer TJ, Zarei M, Segars WP, Samei E, Abadi E. A systematic assessment of photon-counting CT for bone mineral density and microarchitecture quantifications. Proc SPIE Int Soc Opt Eng. 2023;12463.

Quintiens J, van Lenthe GH. Photon-counting computed tomography for microstructural imaging of bone and joints. Curr Osteoporos Rep. 2024;22:387–95.

PubMed  Google Scholar 

Nowak T, Eberhard M, Schmidt B, Frey D, Distler O, Saltybaeva N, et al. Bone mineral density quantification from localizer radiographs: accuracy and precision of energy-integrating detector CT and photon-counting detector CT. Radiology. 2021;298:147–52.

PubMed  Google Scholar 

Thomsen FSL, Horstmeier S, Niehoff JH, Peña JA, Borggrefe J. Effective spatial resolution of photon counting CT for imaging of trabecular structures is superior to conventional clinical CT and similar to high resolution peripheral CT. Invest Radiol. 2022;57:620–6.

CAS  PubMed  Google Scholar 

Depalle B, Chapurlat R, Walter-Le-Berre H, Bou-Saïd B, Follet H. Finite element dependence of stress evaluation for human trabecular bone. J Mech Behav Biomed Mater. 2013;18:200–12.

CAS  PubMed  Google Scholar 

Mizrahi J, Silva MJ, Keaveny TM, Edwards WT, Hayes WC. Finite-element stress analysis of the normal and osteoporotic lumbar vertebral body. Spine (Phila Pa 1976). 1993;18:2088–96.

Wesseling-Perry K, Salusky IB. Chronic kidney disease: mineral and bone disorder in children. Semin Nephrol. 2013;33:169–79.

CAS  PubMed  PubMed Central  Google Scholar 

Schousboe JT, Lewis JR, Kiel DP. Abdominal aortic calcification on dual-energy X-ray absorptiometry: methods of assessment and clinical significance. Bone. 2017;104:91–100.

CAS  PubMed  Google Scholar 

Başaloğlu C, Güngör Ö, Balcı A. The effect of abdominal anatomy on the measurement of bone mineral density with dual-energy X-ray absorptiometry. J Comput Assist Tomogr. 2021;45:458–62.

PubMed  Google Scholar 

Ho LT, Sprague SM. Renal osteodystrophy in chronic renal failure. Semin Nephrol. 2002;22:488–93.

PubMed  Google Scholar 

Hu N, Wang M, Yang M, Chen X, Wang J, Xie C, et al. Bone mineral density in lower thoracic vertebra for osteoporosis diagnosis in older adults during CT lung cancer screening. BMC Geriatr. 2024;24:237.

PubMed  PubMed Central  Google Scholar 

Rühling S, Scharr A, Sollmann N, Wostrack M, Löffler MT, Menze B, et al. Proposed diagnostic volumetric bone mineral density thresholds for osteoporosis and osteopenia at the cervicothoracic spine in correlation to the lumbar spine. Eur Radiol. 2022;32:6207–14.

PubMed  PubMed Central  Google Scholar 

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