miR-107 modulates EMT progression of OSCC by targeting SNCG and inhibiting the ERK/NF-κB signaling pathways

Crowe DL, Hacia JG, Hsieh CL, Sinha UK, Rice H. Molecular pathology of head and neck cancer. Histol Histopathol. 2002;17:909–14.

CAS  PubMed  Google Scholar 

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: Cancer J Clin. 2011;61:69–90.

PubMed  Google Scholar 

Wang B, Zhang S, Yue K, Wang XD. The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases. Chin J Cancer. 2013;32:614–8.

PubMed  PubMed Central  Google Scholar 

Noguti J, De Moura CF, De Jesus GP, Da Silva VH, Hossaka TA, Oshima CT, Ribeiro DA. Metastasis from oral cancer: an overview. Cancer Genomics Proteomics. 2012;9:329–35.

CAS  PubMed  Google Scholar 

Patel RS, Dirven R, Clark JR, Swinson BD, Gao K, O’Brien CJ. The prognostic impact of extent of bone invasion and extent of bone resection in oral carcinoma. Laryngoscope. 2008;118:780–5.

PubMed  Google Scholar 

Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM. The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis. Virchows Archiv: Int J Pathol. 2015;466:363–73.

CAS  Google Scholar 

Liao CT, Lee LY, Huang SF, Chen IH, Kang CJ, Lin CY, Fan KH, Wang HM, Ng SH, Yen TC. Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes. Int J Radiat Oncol Biol Phys. 2011;81:930–7.

PubMed  Google Scholar 

Siriwardena B, Karunathilaka H, Kumarasiri PVR, Tilakaratne WM. Impact of histological and molecular parameters on prognosis of oral squamous cell carcinoma: analysis of 290 cases. Biomed Res Int. 2020;2020:2059240.

CAS  PubMed  PubMed Central  Google Scholar 

Jia B, Zhang S, Wu S, Zhu Q, Li W. MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway. IUBMB Life. 2021;73:264–72.

CAS  PubMed  Google Scholar 

Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15:509–24.

CAS  PubMed  Google Scholar 

Parkins EV, Gross C. Small differences and big changes: the many variables of MicroRNA expression and function in the brain. J Neurosci: Off J Soc Neurosci. 2024;44:e0365242024.

CAS  Google Scholar 

Alkhazaali-Ali Z, Sahab-Negah S, Boroumand AR, Tavakol-Afshari J. MicroRNA (miRNA) as a biomarker for diagnosis, prognosis, and therapeutics molecules in neurodegenerative disease. Biomed & Pharmacotherapy = Biomed & Pharmacotherapie. 2024;177:116899.

CAS  Google Scholar 

Mustafov D, Ahmad MS, Serrano A, Braoudaki M, Siddiqui SS. MicroRNA:Siglec crosstalk in cancer progression. Curr Opin Chem Biol. 2024;81: 102502.

CAS  PubMed  Google Scholar 

Dioguardi M, Spirito F, Iacovelli G, Sovereto D, Laneve E, Laino L, Caloro GA, Nabi AQ, Ballini A, Lo Muzio L, Troiano G. The potential microRNA prognostic signature in HNSCCs: a systematic review. Non-coding RNA. 2023;9:54.

CAS  PubMed  PubMed Central  Google Scholar 

Malekjafarian SM, Mohtasham N, Mirhashemi M, Sadeghi M, Arab F, Mohajertehran F. Metastasis and cell proliferation inhibition by microRNAs and its potential therapeutic applications in OSCC: a systematic review. Pathol Res Pract. 2024;262: 155532.

CAS  PubMed  Google Scholar 

Na C, Li X, Zhang J, Han L, Li Y, Zhang H. miR-107 targets TRIAP1 to regulate oral squamous cell carcinoma proliferation and migration. Int J Clin Exp Pathol. 2019;12:1820–5.

CAS  PubMed  PubMed Central  Google Scholar 

Liu KYP, Zhu SY, Brooks D, Bowlby R, Durham JS, Ma Y, Moore RA, Mungall AJ, Jones S, Poh CF. Tumor microRNA profile and prognostic value for lymph node metastasis in oral squamous cell carcinoma patients. Oncotarget. 2020;11:2204–15.

PubMed  PubMed Central  Google Scholar 

Guo J, Shou C, Meng L, Jiang B, Dong B, Yao L, Xie Y, Zhang J, Chen Y, Budman DR, Shi YE. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer. 2007;121:1296–305.

CAS  PubMed  Google Scholar 

Liu C, Dong B, Lu A, Qu L, Xing X, Meng L, Wu J, Eric Shi Y, Shou C. Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen. BMC Cancer. 2010;10:359.

PubMed  PubMed Central  Google Scholar 

Pan Y, Zheng Y, Yang J, Wei Y, Wu H, Liu S, Yin A, Hu J, Zeng Y. A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG. Future Oncol (London, England). 2022;18:3179–90.

CAS  Google Scholar 

Zhang J, Liu XH, Li C, Wu XX, Chen YL, Li WW, Li X, Gong F, Tang Q, Jiang D. Sncg promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway. J Exp Clin Cancer Res: CR. 2020;39:79.

PubMed  PubMed Central  Google Scholar 

Liang W, Miao S, Zhang B, He S, Shou C, Manivel P, Krishna R, Chen Y, Shi YE. Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Oncogene. 2015;34:2398–405.

CAS  PubMed  Google Scholar 

He J, Xie N, Yang J, Guan H, Chen W, Wu H, Yuan Z, Wang K, Li G, Sun J, Yu L. SiRNA-mediated suppression of synuclein γ inhibits MDA-MB-231 cell migration and proliferation by downregulating the phosphorylation of AKT and ERK. J Breast Cancer. 2014;17:200–6.

PubMed  PubMed Central  Google Scholar 

Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. Cancer Res. 2007;67:626–33.

CAS  PubMed  Google Scholar 

Wang K, Shen Y, Xu J, Li Z, Liu Y, Yu C, Peng L, Zheng J, Zeng Y. Evaluation of synuclein-γ levels by novel monoclonal antibody in saliva and cancer tissues from oral squamous cell carcinoma patients. Neoplasma. 2020;67:707–13.

CAS  PubMed  Google Scholar 

Yang J, Pan Y, Peng L, Zhang L, Zhao J, Zheng Z, Zheng J, Xu X, Zeng Y. Upregulation of Synuclein-γ and Snai1 contributes to poor clinical prognosis in oral squamous cell carcinoma patients. BioMed Res Int. 2022;2022:6534626.

PubMed  PubMed Central  Google Scholar 

Yang J, Ren Z, Wang F, Zheng J, Zhuang Z, Zeng Y. γ-Synuclein promotes proliferation and inhibits apoptosis of oral squamous cell carcinoma via JAK2/STAT5b signaling pathway. Am J Cancer Res. 2024;14:2408–23.

CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Zhang Y, Luo F, Zhou Q, Zhu L. The role of microRNAs in the gastric cancer tumor microenvironment. Mol Cancer. 2024;23:170.

CAS  PubMed  PubMed Central  Google Scholar 

Ellakwa DE, Mushtaq N, Khan S, Jabbar A, Abdelmalek MA, Wadan AS, Ellakwa TE, Raza A. Molecular functions of micrornas in colorectal cancer: recent roles in proliferation, angiogenesis, apoptosis, and chemoresistance. Naunyn-Schmiedebergs Arch Pharmacol. 2024;397:5617–30.

CAS  PubMed  Google Scholar 

Piao L, Zhang M, Datta J, Xie X, Su T, Li H, Teknos TN, Pan Q. Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma. Molecular Therapy: J Am Soc Gene Therapy. 2012;20:1261–9.

CAS  Google Scholar 

Bracken CP, Goodall GJ, Gregory PA. RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer. Semin Cancer Biol. 2024;102–103:4–16.

PubMed  Google Scholar 

Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22:894–907.

CAS  PubMed  PubMed Central  Google Scholar 

Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008;9:582–9.

CAS  PubMed  PubMed Central  Google Scholar 

Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68:7846–54.

CAS  PubMed  Google Scholar 

Gregory PA, Bracken CP, Bert AG, Goodall GJ. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell cycle (Georgetown, Tex). 2008;7:3112–8.

CAS  PubMed  Google Scholar 

Su SG, Yang M, Zhang MF, Peng QZ, Li MY, Liu LP, Bao SY. miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma. Int J Biochem Cell Biol. 2017;91:53–9.

CAS  PubMed  Google Scholar 

Xiong J, Wang D, Wei A, Lu H, Tan C, Li A, Tang J, Wang Y, He S, Liu X, Hu W. Deregulated expression of miR-107 inhibits metastasis of PDAC t

Comments (0)

No login
gif