Beets-Tan RGH, Lambregts DMJ, Maas M et al (2018) Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol 28:1465–1475

Article  PubMed  Google Scholar 

Glynne-Jones R, Wyrwicz L, Tiret E et al (2017) Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 28:iv22–iv40

Article  CAS  PubMed  Google Scholar 

Lee S, Kassam Z, Baheti AD et al (2023) Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel. Abdom Radiol (NY) 48:2792–2806

Article  PubMed  PubMed Central  Google Scholar 

Sauer R, Liersch T, Merkel S et al (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 30:1926–1933

Article  CAS  PubMed  Google Scholar 

Ma B, Gao P, Wang H et al (2017) What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long-term outcomes over the past decades? A systematic review and meta-analysis based on 41,121 patients. Int J Cancer 141:1052–1065

Article  CAS  PubMed  Google Scholar 

Ozturk SK, Martinez CG, Mens D et al (2024) Lymph node regression after neoadjuvant chemoradiotherapy in rectal cancer. Histopathology 84:935–946

Article  PubMed  Google Scholar 

Smith FM, Winter D (2017) Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer: long-term outcomes and prognostic significance of pathologic nodal status (KROG 09-01). Ann Surg 265:e27–e28

Article  PubMed  Google Scholar 

Tranchart H, Lefèvre JH, Svrcek M, Flejou JF, Tiret E, Parc Y (2013) What is the incidence of metastatic lymph node involvement after significant pathologic response of primary tumor following neoadjuvant treatment for locally advanced rectal cancer?. Ann Surg Oncol 20:1551–1559

Article  PubMed  Google Scholar 

Ihnát P, Židlík V, Ihnát Rudinská L, Koscielnik P, Hanzlíková P, Škarda J (2023) Magnetic resonance imaging in preoperative assessment of the mesorectal nodal status of patients with rectal cancer - Can it be trusted?. Eur J Radiol 165:110961

Article  PubMed  Google Scholar 

Lord AC, D’Souza N, Shaw A et al (2022) MRI-diagnosed tumor deposits and EMVI status have superior prognostic accuracy to current clinical TNM staging in rectal cancer. Ann Surg 276:334–344

Article  PubMed  Google Scholar 

Li T, Yang Y, Wu W et al (2021) Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location. Transl Oncol 14:101190

Article  CAS  PubMed  PubMed Central  Google Scholar 

Veronese N, Nottegar A, Pea A et al (2016) Prognostic impact and implications of extracapsular lymph node involvement in colorectal cancer: a systematic review with meta-analysis. Ann Oncol 27:42–48

Article  CAS  PubMed  Google Scholar 

Komuta K, Okudaira S, Haraguchi M, Furui J, Kanematsu T (2001) Identification of extracapsular invasion of the metastatic lymph nodes as a useful prognostic sign in patients with resectable colorectal cancer. Dis Colon Rectum 44:1838–1844

Article  CAS  PubMed  Google Scholar 

Lambregts DMJ, Bogveradze N, Blomqvist LK et al (2022) Current controversies in TNM for the radiological staging of rectal cancer and how to deal with them: results of a global online survey and multidisciplinary expert consensus. Eur Radiol 32:4991–5003

Article  PubMed  PubMed Central  Google Scholar 

Fassan M, Vianello L, Sacchi D et al (2018) Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases. Cancer Cell Int 18:131

Article  PubMed  PubMed Central  Google Scholar 

Fujii T, Tabe Y, Yajima R et al (2011) Process of distant lymph node metastasis in colorectal carcinoma: implication of extracapsular invasion of lymph node metastasis. BMC Cancer 11:216

Article  PubMed  PubMed Central  Google Scholar 

Li QY, Yang D, Guan Z et al (2024) Extranodal extension at pretreatment MRI and the prognostic value for patients with rectal cancer. Radiology 310:e232605

Article  PubMed  Google Scholar 

Prall F, Wöhlke M, Klautke G, Schiffmann L, Fietkau R, Barten M (2006) Tumour regression and mesorectal lymph node changes after intensified neoadjuvant chemoradiation for carcinoma of the rectum. APMIS 114:201–210

Article  PubMed  Google Scholar 

Battersby NJ, Dattani M, Rao S et al (2017) A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial. Trials 18:394

Article  PubMed  PubMed Central  Google Scholar 

Amin MB, Edge SB, Greene FL et al (2017) AJCC cancer staging manual. 8th edn. Springer, New York

DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845

Article  CAS  PubMed  Google Scholar 

Kim TH, Firat C, Thompson HM et al (2023) Extramural venous invasion and tumor deposit at diffusion-weighted MRI in patients after neoadjuvant treatment for rectal cancer. Radiology 308:e230079

Article  PubMed  Google Scholar 

Schaap DP, Voogt ELK, Burger JWA et al (2021) Prognostic Implications of MRI-Detected EMVI and Tumor Deposits and Their Response to Neoadjuvant Therapy in cT3 and cT4 Rectal Cancer. Int J Radiat Oncol Biol Phys 111:816–825

Article  PubMed  Google Scholar 

Chand M, Swift RI, Tekkis PP, Chau I, Brown G (2014) Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer. Br J Cancer 110:19–25

Article  CAS  PubMed  Google Scholar 

Jabi R, Al Jarroudi O, Bouziane M (2022) The extracapsular lymph node extension predicts outcomes in colorectal cancer: a short review. Curr Drug Targets 23:358–363

Article  CAS  PubMed  Google Scholar 

Kim YI, Cho H, Kim CW et al (2021) Prognostic impact of extranodal extension in rectal cancer patients undergoing radical resection after preoperative chemoradiotherapy. Clin Colorectal Cancer 20:e35–e42

Article  PubMed  Google Scholar 

Kimura Y, Sumi M, Sakihama N, Tanaka F, Takahashi H, Nakamura T (2008) MR imaging criteria for the prediction of extranodal spread of metastatic cancer in the neck. AJNR Am J Neuroradiol 29:1355–1359

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arrichiello G, Pirozzi M, Facchini BA et al (2022) Beyond N staging in colorectal cancer: current approaches and future perspectives. Front Oncol 12:937114

Article  PubMed  PubMed Central  Google Scholar 

van den Brekel MW, Lodder WL, Stel HV, Bloemena E, Leemans CR, van der Waal I (2012) Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck. Head Neck 34:840–845

Article  PubMed  Google Scholar 

Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740

Article  CAS  PubMed  Google Scholar 

Sebag-Montefiore D, Stephens RJ, Steele R et al (2009) Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 373:811–820

Article  PubMed  PubMed Central  Google Scholar 

Suzuki H, Fujii T, Asao T et al (2014) Extracapsular lymph node involvement is associated with colorectal liver metastases and impact outcome after hepatectomy for colorectal metastases. World J Surg 38:2079–2088

Article  PubMed  Google Scholar 

Heide J, Krüll A, Berger J (2004) Extracapsular spread of