Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J (2018) Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res 6(1):15

Article  PubMed  PubMed Central  Google Scholar 

Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M, Cai J, Rose P, Mao J, Zhu YZ (2023) Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct Target Ther 8(1):68

Article  PubMed  PubMed Central  Google Scholar 

Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376(9746):1094–1108. https://doi.org/10.1016/s0140-6736(10)60826-4

Article  PubMed  Google Scholar 

Anderson J, Caplan L, Yazdany J, Robbins ML, Neogi T, Michaud K, Saag KG, O’Dell JR, Kazi S (2012) Rheumatoid arthritis disease activity measures: American college of rheumatology recommendations for use in clinical practice. Arthritis Care Res (Hoboken) 64(5):640–647. https://doi.org/10.1002/acr.21649

Article  PubMed  Google Scholar 

Pisaniello HL, Whittle SL, Lester S, Menz F, Metcalf R, McWilliams L, Hill CL, Proudman S (2022) Using the derived 28-joint disease activity score patient-reported components (DAS28-P) index as a discriminatory measure of response to disease-modifying anti-rheumatic drug therapy in early rheumatoid arthritis. BMC Rheumatol 6(1):67. https://doi.org/10.1186/s41927-022-00299-3

Article  PubMed  PubMed Central  Google Scholar 

Orr CK, Najm A, Young F, McGarry T, Biniecka M, Fearon U, Veale DJ (2018) The utility and limitations of CRP, ESR and DAS28-CRP in appraising disease activity in rheumatoid arthritis. Front Med 5:185

Article  Google Scholar 

Greenmyer JR, Stacy JM, Sahmoun AE, Beal JR, Diri E (2020) DAS28-CRP cutoffs for high disease activity and remission are lower than DAS28-ESR in rheumatoid arthritis. ACR open rheumatology 2(9):507–511

Article  PubMed  PubMed Central  Google Scholar 

Hansen SM, Hetland ML, Pedersen J, Østergaard M, Rubak TS, Bjorner JB (2017) Work ability in rheumatoid arthritis patients: a register study on the prospective risk of exclusion and probability of returning to work. Rheumatology 56(7):1135–1143

Article  PubMed  Google Scholar 

Fleischmann R, van der Heijde D, Koenig AS, Pedersen R, Szumski A, Marshall L, Bananis E (2015) How much does disease activity score in 28 joints ESR and CRP calculations underestimate disease activity compared with the simplified disease activity index? Ann Rheum Dis 74(6):1132–1137

Article  CAS  PubMed  Google Scholar 

Álvaro-Gracia JM, Sanchez-Piedra C, Culqui D, Rosello R, Garcia-Dorta A, Campos C, Manrique-Arija S, Ruiz-Montesinos D, Ros-Vilamajo I, Rodríguez-Lozano C (2023) Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study. RMD Open 9(1):e002936

Article  PubMed  Google Scholar 

Sproston NR, Ashworth JJ (2018) Role of C-reactive protein at sites of inflammation and infection. Front Immunol 9:754. https://doi.org/10.3389/fimmu.2018.00754

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranneh Y, Ali F, Akim AM, Hamid HA, Khazaai H, Fadel A (2017) Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review. Appl Biol Chem 60:327–338

Article  CAS  Google Scholar 

Zainal Z, Khaza’ai H, Radhakrishnan AK, Chang SK (2022) Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: evidence from preclinical and clinical studies. Food Res Int 156:111175

Article  CAS  PubMed  Google Scholar 

Zainal Z, Longman AJ, Hurst S, Duggan K, Hughes CE, Caterson B, Harwood JL (2009) Modification of palm oil for anti-inflammatory nutraceutical properties. Lipids 44:581–592

Article  CAS  PubMed  Google Scholar 

Saboori S, Shab-Bidar S, Speakman J, Yousefi Rad E, Djafarian K (2015) Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials. Eur J Clin Nutr 69(8):867–873

Article  CAS  PubMed  Google Scholar 

Qureshi AA (2022) Tocotrienols: exciting biological and pharmacological properties of tocotrienols and other naturally occurring compounds, Part I. Ann Clin Case Rep 7(1):2194

PubMed  PubMed Central  Google Scholar 

Asbaghi O, Sadeghian M, Nazarian B, Sarreshtedari M, Mozaffari-Khosravi H, Maleki V, Alizadeh M, Shokri A, Sadeghi O (2020) The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. Sci Rep 10(1):17234

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nezamoleslami S, Ghiasvand R, Feizi A, Salesi M, Pourmasoumi M (2020) The relationship between dietary patterns and rheumatoid arthritis: a case–control study. Nutr Metab 17:1–8

Article  Google Scholar 

Asbaghi O, Sadeghian M, Nazarian B, Sarreshtedari M, Mozaffari-Khosravi H, Maleki V, Alizadeh M, Shokri A, Sadeghi O (2020) The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. Sci Rep 10(1):17234. https://doi.org/10.1038/s41598-020-73741-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zainal Z, Rahim AA, Radhakrishnan AK, Chang SK, Khaza’ai H (2019) Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo. Sci Rep 9(1):16793

Article  PubMed  PubMed Central  Google Scholar 

Haleagrahara N, Swaminathan M, Chakravarthi S, Radhakrishnan A (2014) Therapeutic efficacy of vitamin E-tocotrienol in collagen-induced rat model of arthritis. BioMed Res Int. https://doi.org/10.1155/2014/539540

Article  PubMed  PubMed Central  Google Scholar 

Paglia MDG, Silva MT, Lopes LC, Barberato-Filho S, Mazzei LG, Abe FC, de Cássia BC (2021) Use of corticoids and non-steroidal anti-inflammatories in the treatment of rheumatoid arthritis: systematic review and network meta-analysis. PLoS ONE 16(4):e0248866

Article  PubMed  PubMed Central  Google Scholar 

Abbasi M, Mousavi MJ, Jamalzehi S, Alimohammadi R, Bezvan MH, Mohammadi H, Aslani S (2019) Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol 234(7):10018–10031

Article  CAS  PubMed  Google Scholar 

Stone S, Malanga GA, Capella T (2021) Corticosteroids: review of the history, the effectiveness, and adverse effects in the treatment of joint pain. Pain Physician 24(S1):S233

PubMed  Google Scholar 

Petta I, Peene I, Elewaut D, Vereecke L, De Bosscher K (2019) Risks and benefits of corticosteroids in arthritic diseases in the clinic. Biochem Pharmacol 165:112–125

Article  CAS  PubMed  Google Scholar 

Combe B (2007) Early rheumatoid arthritis: strategies for prevention and management. Best Pract Res Clin Rheumatol 21(1):27–42

Article  PubMed  Google Scholar 

Prasad P, Verma S, Surbhi GNK, Chaturvedi V, Mittal SA (2023) Rheumatoid arthritis: advances in treatment strategies. Mol Cell Biochem 478(1):69–88

Article  CAS  PubMed  Google Scholar 

Ahsan H, Ahad A, Iqbal J, Siddiqui WA (2014) Pharmacological potential of tocotrienols: a review. Nutr Metab 11(1):52. https://doi.org/10.1186/1743-7075-11-52

Article  CAS  Google Scholar 

Koay YY, Tan GCJ, Phang SCW, Ho J-I, Chuar PF, Ho LS, Ahmad B, Abdul Kadir K (2021) A phase IIb randomized controlled trial investigating the effects of tocotrienol-rich vitamin E on diabetic kidney disease. Nutrients 13(1):258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Musa AF, Dillon J, Taib MEM, Yunus AM, Nordin RB, Hay YK (2018) A study protocol for a randomized controlled trial on the prevention of atrial fibrillation after coronary artery bypass grafting surgery using tocotrienol, an isomer of Vitamin E. F1000Research 7:215

Article  Google Scholar 

Brunnström K, Barkowsky M (2018) Statistical quality of experience analysis: on planning the sample size and statistical significance testing. J Electron Imaging 27(5):053013–053013

Article