Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: A review. JAMA. 2021;325:568–78.
Article CAS PubMed PubMed Central Google Scholar
Courties A, Kouki I, Soliman N, Mathieu S, Sellam J. Osteoarthritis year in review 2024: epidemiology and therapy. Osteoarthritis Cartilage. 2024;32:1397–404.
Collaborators G, B D O M D. Global, regional, and National burden of other musculoskeletal disorders, 1990–2020, and projections to 2050: a systematic analysis of the global burden of disease study 2021. Lancet Rheumatol. 2023;5:e670–82.
Cisternas MG, Murphy L, Sacks JJ, Solomon DH, Pasta DJ, Helmick CG. Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US Population-Based survey. Arthritis Care Res (Hoboken). 2016;68:574–80.
Losina E, Paltiel AD, Weinstein AM, Yelin E, Hunter DJ, Chen SP, et al. Lifetime medical costs of knee osteoarthritis management in the united States: impact of extending indications for total knee arthroplasty. Arthritis Care Res (Hoboken). 2015;67:203–15.
Murphy LB, Cisternas MG, Pasta DJ, Helmick CG, Yelin EH. Medical expenditures and earnings losses among US adults with arthritis in 2013. Arthritis Care Res (Hoboken). 2018;70:869–76.
Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104:293–311.
Welhaven HD, Welfley AH, June RK. Osteoarthritis year in review 2024: molecular biomarkers of osteoarthritis. Osteoarthritis Cartilage. 2025;33:67–87.
Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2017;13:302–11.
Article CAS PubMed Google Scholar
Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble uric acid promotes atherosclerosis via AMPK (AMP-Activated protein Kinase)-Mediated inflammation. Arterioscler Thromb Vasc Biol. 2020;40:570–82.
Article CAS PubMed Google Scholar
Gherghina ME, Peride I, Tiglis M, Neagu TP, Niculae A, Checherita IA. Uric acid and oxidative Stress-Relationship with cardiovascular, metabolic, and renal impairment. Int J Mol Sci 2022, 23.
Garcia Puig J, Beltran L, Mejia Chew C, Torres R, Tebar Marquez D, Pose Reino A. Ultrasound in the diagnosis of asymptomatic hyperuricaemia and gout. Rev Clin Esp (Barc). 2016;216:445–50.
Rohatgi A, Westerterp M, von Eckardstein A, Remaley A, Rye KA. HDL in the 21st century: A multifunctional roadmap for future HDL research. Circulation. 2021;143:2293–309.
Article PubMed PubMed Central Google Scholar
Xie Y, Huang K, Zhang X, Wu Z, Wu Y, Chu J, et al. Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis. Front Med (Lausanne). 2023;10:1164096.
Huang X, Hu L, Tao S, Xue T, Hou C, Li J. Relationship between uric acid to high-density cholesterol ratio (UHR) and Circulating alpha-klotho: evidence from NHANES 2007–2016. Lipids Health Dis. 2024;23:244.
Article CAS PubMed PubMed Central Google Scholar
Li Z, Liu Q, Yao Z. The serum uric acid-to-high-density lipoprotein cholesterol ratio is a predictor for all-cause and cardiovascular disease mortality: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1417485.
Dikker O, Aktas A, Sahin M, Dogan M, Dag H. The association of serum uric acid levels and various uric acid-Related ratios with insulin resistance and obesity: A preliminary study in adolescents. Child (Basel) 2023, 10.
Wang L, Liu L, Luo H, Wu Y, Zhu L. Correlation between the ratio of uric acid to High-Density lipoprotein cholesterol (UHR) and diabetic retinopathy in patients with type 2 diabetes mellitus:a Cross-Sectional study. Diabetes Metab Syndr Obes. 2025;18:173–83.
Article PubMed PubMed Central Google Scholar
Liu Z, Tang Y, Sun Y, Lei M, Cheng M, Pan X, et al. Uric acid-to-high-density lipoprotein cholesterol ratio and osteoporosis: evidence from the National health and nutrition examination survey. J Orthop Surg (Hong Kong). 2024;32:10225536241293489.
Hart DJ, Doyle DV, Spector TD. Association between metabolic factors and knee osteoarthritis in women: the Chingford study. J Rheumatol. 1995;22:1118–23.
Chen D, Xu H, Sun L, Li Y, Wang T, Li Y. Assessing causality between osteoarthritis with urate levels and gout: a bidirectional Mendelian randomization study. Osteoarthritis Cartilage. 2022;30:551–8.
Article CAS PubMed Google Scholar
Herrero-Manley L, Alabajos-Cea A, Suso-Marti L, Cuenca-Martinez F, Calatayud J, Casana J, et al. Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis. Front Nutr. 2023;10:1126796.
Article PubMed PubMed Central Google Scholar
Zhang K, Ji Y, Dai H, Khan AA, Zhou Y, Chen R, et al. High-Density lipoprotein cholesterol and Apolipoprotein A1 in synovial fluid: potential predictors of disease severity of primary knee osteoarthritis. Cartilage. 2021;13:S1465–73.
Li H, George DM, Jaarsma RL, Mao X. Metabolic syndrome and components exacerbate osteoarthritis symptoms of pain, depression and reduced knee function. Ann Transl Med. 2016;4:133.
Article CAS PubMed PubMed Central Google Scholar
Schwager JL, Nevitt MC, Torner J, Lewis CE, Matthan NR, Wang N, et al. Association of serum Low-Density lipoprotein, High-Density lipoprotein, and total cholesterol with development of knee osteoarthritis. Arthritis Care Res (Hoboken). 2022;74:274–80.
Article CAS PubMed Google Scholar
Aydın C, Emlek N. The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion. Kardiologiia. 2021;61:61–5.
Farnaghi S, Prasadam I, Cai G, Friis T, Du Z, Crawford R, et al. Protective effects of mitochondria-targeted antioxidants and Statins on cholesterol-induced osteoarthritis. Faseb J. 2017;31:356–67.
Article CAS PubMed Google Scholar
Hosokawa H, Akagi R, Watanabe S, Horii M, Shinohara M, Mikami Y, et al. Nuclear receptor subfamily 1 group D member 1 in the pathology of obesity-induced osteoarthritis progression. J Orthop Res. 2023;41:930–41.
Article CAS PubMed Google Scholar
Liu X, Guo Q, Wang L, Gu Y, Meng S, Gu Y, et al. Metformin attenuates high-fat diet induced metabolic syndrome related osteoarthritis through Inhibition of prostaglandins. Front Cell Dev Biol. 2023;11:1184524.
Article PubMed PubMed Central Google Scholar
Ossoli A, Wolska A, Remaley AT, Gomaraschi M. High-density lipoproteins: A promising tool against cancer. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159068.
Article CAS PubMed Google Scholar
Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Smith TO, et al. Adherence to a mediterranean diet is associated with lower prevalence of osteoarthritis: data from the osteoarthritis initiative. Clin Nutr. 2017;36:1609–14.
Stanton KM, Kienzle V, Dinnes DLM, Kotchetkov I, Jessup W, Kritharides L, et al. Moderate- and High-Intensity exercise improves lipoprotein profile and cholesterol efflux capacity in healthy young men. J Am Heart Assoc. 2022;11:e023386.
Article PubMed PubMed Central Google Scholar
Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids Health Dis. 2017;16:132.
Article PubMed PubMed Central Google Scholar
Kim SK, Bae J, Choe JY. The relationship between alcohol consumption and knee osteoarthritis in Korean population over 50 years-old: results from Korea National health and nutrition examination survey. Med (Baltim). 2021;100:e24746.
Comments (0)