Weight-based tranexamic acid lowers the risk of postoperative blood loss and transfusion requirements compared with fixed-dose regimen in revision knee arthroplasty: a comparative study

Bedard NA, Carender CN, DeMik DE, Browne JA, Schwarzkopf R, Callaghan JJ (2021) The impact of transitioning from international classification of diseases, ninth revision to international classification of diseases, tenth revision on reported complication rates following primary total knee arthroplasty. J Arthroplasty 36(5):1617–1620. https://doi.org/10.1016/j.arth.2020.12.009

Article  PubMed  Google Scholar 

Premkumar A, Kolin DA, Farley KX, Wilson JM, McLawhorn AS, Cross MB, Sculco PK (2021) Projected economic burden of periprosthetic joint infection of the hip and knee in the United States. J Arthroplasty 36(5):1484-1489.e3. https://doi.org/10.1016/j.arth.2020.12.005

Article  PubMed  Google Scholar 

Laver L, Maman D, Hirschmann MT, Mahamid A, Bar O, Steinfeld Y, Berkovich Y (2024) Big data analysis reveals significant increases in complications, costs, and hospital stay in revision total knee arthroplasty compared to primary TKA. Knee Surg Sport Tr A. https://doi.org/10.1002/ksa.12499

Article  Google Scholar 

Dobson PF, Reed MR (2020) Prevention of infection in primary THA and TKA. Efort Open Rev. https://doi.org/10.1302/2058-5241.5.200004

Article  PubMed  PubMed Central  Google Scholar 

Liu KC, Piple AS, Richardson MK, Mayer LW, Mayfield CK, Christ AB, Lieberman JR, Heckmann ND (2023) Increased risk of venous thromboembolism in patients with postoperative anemia after total joint arthroplasty: are transfusions to blame? J Bone Joint Surg Am 105(17):1354–1361. https://doi.org/10.2106/JBJS.23.00146

Article  PubMed  Google Scholar 

Albana MF, Yayac MF, Sun K, Post ZD, Ponzio DY, Ong AC (2024) Early discharge for revision total knee and hip arthroplasty: predictors of success. J Arthroplasty 39(5):1298–1303. https://doi.org/10.1016/j.arth.2023.11.008

Article  PubMed  Google Scholar 

Yamasaki S, Masuhara K, Fuji T (2004) Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases. Int Orthop 28(2):69–73. https://doi.org/10.1007/s00264-003-0511-4

Article  PubMed  Google Scholar 

Drain NP, Gobao VC, Bertolini DM, Smith C, Shah NB, Rothenberger SD, Dombrowski ME, O’Malley MJ, Klatt BA, Hamlin BR, Urish KL (2020) Administration of tranexamic acid improves long-term outcomes in total knee arthroplasty. J Arthroplasty 35(6S):S201–S206. https://doi.org/10.1016/j.arth.2020.02.047

Article  PubMed  PubMed Central  Google Scholar 

Nielsen CS, Jans Ø, Ørsnes T, Foss NB, Troelsen A, Husted H (2016) Combined intra-articular and intravenous tranexamic acid reduces blood loss in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. J Bone Joint Surg Am 98(10):835–841. https://doi.org/10.2106/JBJS.15.00810

Article  PubMed  Google Scholar 

Abdel MP, Chalmers BP, Taunton MJ, Pagnano MW, Trousdale RT, Sierra RJ, Lee YY, Boettner F, Su EP, Haas SB, Figgie MP, Mayman DJ (2018) Intravenous versus topical tranexamic acid in total knee arthroplasty: both effective in a randomized clinical trial of 640 patients. J Bone Joint Surg Am 100(12):1023–1029. https://doi.org/10.2106/JBJS.17.00908

Article  PubMed  Google Scholar 

Smit KM, Naudie DD, Ralley FE, Berta DM, Howard JL (2013) One dose of tranexamic acid is safe and effective in revision knee arthroplasty. J Arthroplasty 28:112–115. https://doi.org/10.1016/j.arth.2013.05.036

Article  PubMed  Google Scholar 

Laoruengthana A, Rattanaprichavej P, Rasamimongkol S, Galassi M, Weerakul S, Pongpirul K (2019) Intra-articular tranexamic acid mitigates blood loss and morphine use after total knee arthroplasty. A randomized controlled trial. J Arthroplasty. https://doi.org/10.1016/j.arth.2019.01.030

Article  PubMed  Google Scholar 

Shichman I, Oakley CT, Thomas J, Rozell JC, Aggarwal VK, Schwarzkopf R (2023) Comparison of aseptic partial- and full-component revision total knee arthroplasty. J Arthroplasty. https://doi.org/10.1016/j.arth.2022.09.025

Article  PubMed  Google Scholar 

Parvizi J, Fassihi SC, Enayatollahi MA (2016) Diagnosis of periprosthetic joint infection following hip and knee arthroplasty. Orthop Clin N Am 47(3):505–515. https://doi.org/10.1016/j.ocl.2016.03.001

Article  Google Scholar 

Buijs GS, Kievit AJ, Schafroth MU, Hirschmann MT, Blankevoort L (2024) Weight-bearing pain and implant migration, progressive radiolucencies, radiolucency more than 2 mm and subsidence on radiographs and CT are generally accepted criteria for knee arthroplasty loosening: an international Delphi consensus study. Knee Surg Sport Tr A. https://doi.org/10.1002/ksa.12419

Article  Google Scholar 

McCormack PL (2012) Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 72(5):585–617. https://doi.org/10.2165/11209070-000000000-00000

Article  CAS  PubMed  Google Scholar 

Carson JL, Stanworth SJ, Guyatt G, Valentine S, Dennis J, Bakhtary S, Cohn CS, Dubon A, Grossman BJ, Gupta GK, Hess AS, Jacobson JL, Kaplan LJ, Lin Y, Metcalf RA, Murphy CH, Pavenski K, Prochaska MT, Raval JS, Salazar E, Saifee NH, Tobian AAR, So-Osman C, Waters J, Wood EM, Zantek ND, Pagano MB (2023) Red blood cell transfusion: 2023 AABB International guidelines. Jama-J Am Med Assoc 330(19):1892–1902. https://doi.org/10.1001/jama.2023.12914

Article  Google Scholar 

Sales CM, Haq F, Bustami R, Sun F (2010) Management of isolated soleal and gastrocnemius vein thrombosis. J Vasc Surg 52(5):1251–1254. https://doi.org/10.1016/j.jvs.2010.05.102

Article  PubMed  Google Scholar 

Lotke PA, Steinberg ME, Ecker ML (1994) Significance of deep venous thrombosis in the lower extremity after total joint arthroplasty. Clin Orthop Relat R 299:25–30

Article  Google Scholar 

Killip T, Kimball JT (1967) Treatment of myocardial infarction in a coronary care unit. A two-year experience with 250 patients. Am J Cardiol 20(4):457–464. https://doi.org/10.1016/0002-9149(67)90023-9

Article  PubMed  Google Scholar 

Cao G, Xie J, Huang Z, Huang Q, Chen G, Lei Y, Xu H, Pei F (2018) Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: a prospective randomized clinical trial. Thromb Res. https://doi.org/10.1016/j.thromres.2018.09.054

Article  PubMed  Google Scholar 

Wu Y, Lu X, Ma Y, Zeng Y, Xiong H, Bao X, Shen B (2018) Efficacy and safety of limb position on blood loss and range of motion after total knee arthroplasty without tourniquet: a randomized clinical trial. Int J Surg. https://doi.org/10.1016/j.ijsu.2018.11.008

Article  PubMed  Google Scholar 

Legnani C, Oriani G, Parente F, Ventura A (2019) Reducing transfusion requirements following total knee arthroplasty: effectiveness of a double infusion of tranexamic acid. Eur Rev Med Pharmaco. https://doi.org/10.26355/eurrev_201903_17273

Article  Google Scholar 

Fillingham YA, Darrith B, Calkins TE, Abdel MP, Malkani AL, Schwarzkopf R, Padgett DE, Culvern C, Sershon RA, Bini S, Della Valle CJ (2019) 2019 Mark Coventry Award: a multicentre randomized clinical trial of tranexamic acid in revision total knee arthroplasty: does the dosing regimen matter? Bone Joint J 101-B:10–16. https://doi.org/10.1302/0301-620X.101B7.BJJ-2018-1451.R1

Article  PubMed  Google Scholar 

Revel-Vilk S, Karavany B, Saban R, Zelig O, Naamad M, Turniansky M, Savitsky B, Hochner H (2016) Are we choosing wisely with blood use? An assessment of transfusion practices. Blood. https://doi.org/10.1182/blood.v128.22.1003.1003

Article  PubMed  PubMed Central  Google Scholar 

Shander A, Kaufman M, Goodnough LT (2020) How I treat anemia in the perisurgical setting. Blood. https://doi.org/10.1182/blood.2019003945

Article  PubMed  Google Scholar 

Rao SS, Chaudhry YP, Hasan SA, Puvanesarajah V, Amin RM, Oni JK, Sterling RS, Khanuja HS (2021) Factors associated with perioperative transfusion in lower extremity revision arthroplasty under a restrictive blood management protocol. J Am Acad Orthop Sur 29(8):e404–e409. https://doi.org/10.5435/JAAOS-D-20-00185

Article  Google Scholar 

Hines JT, Hernandez NM, Amundson AW, Pagnano MW, Sierra RJ, Abdel MP (2019) Intravenous tranexamic acid safely and effectively reduces transfusion rates in revision total hip arthroplasty. Bone Joint J. https://doi.org/10.1302/0301-620X.101B6.BJJ-2018-1376.R1

Article  PubMed  Google Scholar 

Kuo FC, Lin PY, Wang JW, Lin PC, Lee MS, Chen AF (2018) Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis. Drug Des Devel Ther 12:3163–3170. https://doi.org/10.2147/DDDT.S175407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Samujh C, Falls TD, Wessel R, Smith L, Malkani AL (2014) Decreased blood transfusion following revision total knee arthroplasty using tranexamic acid. J Arthroplasty. https://doi.org/10.1016/j.arth.2014.03.047

Article  PubMed  Google Scholar 

Wang C, Kang P, Ma J, Yue C, Xie J, Pei F (2016)

Comments (0)

No login
gif