Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM (2008) The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 2008, 93(5): 1526-40. https://doi.org/10.1210/jc.2008-0125

Limumpornpetch P, Morgan AW, Tiganescu A, Baxter PD, Nyawira Nyaga V, Pujades-Rodriguez M, Stewart PM (2022) The Effect of Endogenous Cushing Syndrome on All-cause and Cause-specific Mortality. J Clin Endocrinol Metab, 2022, 107(8): 2377-88. https://doi.org/10.1210/clinem/dgac265

Reincke M, Fleseriu M (2023) Cushing Syndrome: A Review. JAMA, 2023, 330(2): 170–81. https://doi.org/10.1001/jama.2023.11305

Vassiliadi DA, Tsagarakis S (2019) Diagnosis and management of primary bilateral macronodular adrenal hyperplasia. Endocr Relat Cancer, 2019, 26(10): R567-R81. https://doi.org/10.1530/ERC-19-0240

Cavalcante IP, Berthon A, Fragoso MC, Reincke M, Stratakis CA, Ragazzon B, Bertherat J (2022) Primary bilateral macronodular adrenal hyperplasia: definitely a genetic disease. Nat Rev Endocrinol, 2022, 18(11): 699–711. https://doi.org/10.1038/s41574-022-00718-y

Bertherat J, Bourdeau I, Bouys L, Chasseloup F, Kamenicky P, Lacroix A (2023) Clinical, Pathophysiologic, Genetic, and Therapeutic Progress in Primary Bilateral Macronodular Adrenal Hyperplasia. Endocr Rev, 2023, 44(4): 567–628. https://doi.org/10.1210/endrev/bnac034

Elhassan YS, Alahdab F, Prete A, Delivanis DA, Khanna A, Prokop L, Murad MH, O’reilly M W, Arlt W, Bancos I (2019) Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess: A Systematic Review and Meta-analysis. Ann Intern Med, 2019, 171(2): 107–16. https://doi.org/10.7326/M18-3630

Prete A, Subramanian A, Bancos I, Chortis V, Tsagarakis S, Lang K, Macech M, Delivanis DA, Pupovac ID, Reimondo G, Marina LV, Deutschbein T, Balomenaki M, O’reilly M W, Gilligan LC, Jenkinson C, Bednarczuk T, Zhang CD, Dusek T, Diamantopoulos A, Asia M, Kondracka A, Li D, Masjkur JR, Quinkler M, Ueland GA, Dennedy MC, Beuschlein F, Tabarin A, Fassnacht M, Ivovic M, Terzolo M, Kastelan D, Young WF Jr., Manolopoulos KN, Ambroziak U, Vassiliadi DA, Taylor AE, Sitch AJ, Nirantharakumar K, Arlt W, Investigators* E E-A, Investigators E E-A (2022) Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors: A Cross-Sectional Multicenter Study. Ann Intern Med, 2022, 175(3): 325–34. https://doi.org/10.7326/M21-1737

Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015) Cushing’s syndrome. Lancet, 2015, 386(9996): 913–27. https://doi.org/10.1016/S0140-6736(14)61375-1

Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A, Endocrine S (2015) Treatment of Cushing’s Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 2015, 100(8): 2807-31. https://doi.org/10.1210/jc.2015-1818

Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM (2023) European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol, 2023, 189(1): G1-G42. https://doi.org/10.1093/ejendo/lvad066

Wang W, Lian P, Deng J, Li H, Zhang X (2022) A 30-Year, Single-Center Experience of Unilateral Adrenalectomy for Primary Bilateral Macronodular Adrenal Hyperplasia. Endocr Pract, 2022, 28(7): 690-5. https://doi.org/10.1016/j.eprac.2022.04.011

Yu Z, Gao J, Sun F (2023) The effect of unilateral adrenalectomy on patients with primary bilateral macronodular adrenal hyperplasia. Hormones (Athens), 2023, 22(2): 235–42. https://doi.org/10.1007/s42000-023-00428-8

Albiger NM, Ceccato F, Zilio M, Barbot M, Occhi G, Rizzati S, Fassina A, Mantero F, Boscaro M, Iacobone M, Scaroni C (2015) An analysis of different therapeutic options in patients with Cushing’s syndrome due to bilateral macronodular adrenal hyperplasia: a single-centre experience. Clin Endocrinol (Oxf), 2015, 82(6): 808–15. https://doi.org/10.1111/cen.12763

Xu Y, Rui W, Qi Y, Zhang C, Zhao J, Wang X, Wu Y, Zhu Q, Shen Z, Ning G, Zhu Y (2013) The role of unilateral adrenalectomy in corticotropin-independent bilateral adrenocortical hyperplasias. World J Surg, 2013, 37(7): 1626-32. https://doi.org/10.1007/s00268-013-2059-9

American Diabetes A (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care, 2010, 33 Suppl 1(Suppl 1): S62-9. https://doi.org/10.2337/dc10-S062

Li JJ, Zhao SP, Zhao D, Lu GP, Peng DQ, Liu J, Chen ZY, Guo YL, Wu NQ, Yan SK, Wang ZW, Gao RL (2023) 2023 China Guidelines for Lipid Management. J Geriatr Cardiol, 2023, 20(9): 621–63. https://doi.org/10.26599/1671-5411.2023.09.008

Zeng Q, Li N, Pan XF, Chen L, Pan A (2021) Clinical management and treatment of obesity in China. Lancet Diabetes Endocrinol, 2021, 9(6): 393–405. https://doi.org/10.1016/S2213-8587(21)00047-4

Morelli V, Reimondo G, Giordano R, Della Casa S, Policola C, Palmieri S, Salcuni AS, Dolci A, Mendola M, Arosio M, Ambrosi B, Scillitani A, Ghigo E, Beck-Peccoz P, Terzolo M, Chiodini I (2014) Long-term follow-up in adrenal incidentalomas: an Italian multicenter study. J Clin Endocrinol Metab 2014(993):827–834. https://doi.org/10.1210/jc.2013-3527

Article  CAS  Google Scholar 

Iacobone M, Citton M, Viel G, Boetto R, Bonadio I, Mondi I, Tropea S, Nitti D, Favia G (2012) Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing’s syndrome. Surgery, 2012, 152(6): 991–7. https://doi.org/10.1016/j.surg.2012.08.054

Kawate H, Kohno M, Matsuda Y, Akehi Y, Tanabe M, Horiuchi T, Ohnaka K, Nomura M, Yanase T, Takayanagi R (2014) Long-term study of subclinical Cushing’s syndrome shows high prevalence of extra-adrenal malignancy in patients with functioning bilateral adrenal tumors. Endocr J, 2014, 61(12): 1205-12. https://doi.org/10.1507/endocrj.EJ14-0155

Koh JM, Song K, Kwak MK, Suh S, Kim BJ, Sung TY, Hong JH, Jeong BC, Kim JH, Lee SH (2024) Adrenalectomy Improves Body Weight, Glucose, and Blood Pressure Control in Patients With Mild Autonomous Cortisol Secretion: Results of an Randomized Controlled Trial by the Co-work of Adrenal Research (COAR) Study. Ann Surg, 2024, 279(6): 945–52. https://doi.org/10.1097/SLA.0000000000006183

Dekkers OM, Horvath-Puho E, Jorgensen JO, Cannegieter SC, Ehrenstein V, Vandenbroucke JP, Pereira AM, Sorensen HT (2013) Multisystem morbidity and mortality in Cushing’s syndrome: a cohort study. J Clin Endocrinol Metab, 2013, 98(6): 2277-84. https://doi.org/10.1210/jc.2012-3582

Lacroix A (2009) ACTH-independent macronodular adrenal hyperplasia. Best Pract Res Clin Endocrinol Metab, 2009, 23(2): 245–59. https://doi.org/10.1016/j.beem.2008.10.011

Bouys L, Vaczlavik A, Jouinot A, Vaduva P, Espiard S, Assie G, Libe R, Perlemoine K, Ragazzon B, Guignat L, Groussin L, Bricaire L, Cavalcante IP, Bonnet-Serrano F, Lefebvre H, Raffin-Sanson ML, Chevalier N, Touraine P, Jublanc C, Vatier C, Raverot G, Haissaguerre M, Maione L, Kroiss M, Fassnacht M, Christin-Maitre S, Pasmant E, Borson-Chazot F, Tabarin A, Vantyghem MC, Reincke M, Kamenicky P, North MO, Bertherat J (2022) Identification of predictive criteria for pathogenic variants of primary bilateral macronodular adrenal hyperplasia (PBMAH) gene ARMC5 in 352 unselected patients. Eur J Endocrinol, 2022, 187(1): 123–34. https://doi.org/10.1530/EJE-21-1032

Osswald A, Quinkler M, Di Dalmazi G, Deutschbein T, Rubinstein G, Ritzel K, Zopp S, Bertherat J, Beuschlein F, Reincke M (2019) Long-Term Outcome of Primary Bilateral Macronodular Adrenocortical Hyperplasia After Unilateral Adrenalectomy. J Clin Endocrinol Metab, 2019, 104(7): 2985-93. https://doi.org/10.1210/jc.2018-02204

Debillon E, Velayoudom-Cephise FL, Salenave S, Caron P, Chaffanjon P, Wagner T, Massoutier M, Lambert B, Benoit M, Young J, Tabarin A, Chabre O (2015) Unilateral Adrenalectomy as a First-Line Treatment of Cushing’s Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia. J Clin Endocrinol Metab, 2015, 100(12): 4417-24. https://doi.org/10.1210/jc.2015-2662

Albiger NM, Regazzo D, Rubin B, Ferrara AM, Rizzati S, Taschin E, Ceccato F, Arnaldi G, Pecori Giraldi F, Stigliano A, Cerquetti L, Grimaldi F, De Menis E, Boscaro M, Iacobone M, Occhi G, Scaroni C (2017) A multicenter experience on the prevalence of ARMC5 mutations in patients with primary bilateral macronodular adrenal hyperplasia: from genetic characterization to clinical phenotype. Endocrine, 2017, 55(3): 959–68. https://doi.org/10.1007/s12020-016-0956-z

Bouys L, Vaduva P, Jouinot A, Violon F, Vaczlavik A, Barat M, Charchar H, Chasseloup F, Kamilaris C, Espiard S, Haissaguerre M, Raverot G, Kroiss M, Berthon A, Perlemoine K, Tauveron I, Guignat L, Libe R, Groussin L, Assie G, Pasmant E, Reincke M, Borson-Chazot F, Ferriere A, Vantyghem MC, Stratakis CA, Kamenicky P, Fragoso M, Chansavang A, Ragazzon B, Bertherat J (2025) KDM1A genetic alterations, a rare cause of primary bilateral macronodular adrenal hyperplasia, strongly associated with food-dependent Cushing’s syndrome: results of its systematic germline screening in 301 index cases and genotype/phenotype correlation. Eur J Endocrinol, 2025, 192(2): 119–27. https://doi.org/10.1093/ejendo/lvaf016

Di Dalmazi G, Vicennati V, Garelli S, Casadio E, Rinaldi E, Giampalma E, Mosconi C, Golfieri R, Paccapelo A, Pagotto U, Pasquali R (2014) Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing’s syndrome: a 15-year retrospective study. Lancet Diabetes Endocrinol, 2014, 2(5): 396–405. https://doi.org/10.1016/S2213-8587(13)70211-0

Khan U (2019) Nonfunctioning and Subclinical Cortisol Secreting Adrenal Incidentalomas and their Association with Metabolic Syndrome: A Systematic Review. Indian J Endocrinol Metab, 2019, 23(3): 332–46. https://doi.org/10.4103/ijem.IJEM_52_19

Zhou J, Zhang M, Bai X, Cui S, Pang C, Lu L, Pang H, Guo X, Wang Y, Xing B (2019) Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China. Int J Endocrinol, 2019, 20197159696. https://doi.org/10.1155/2019/7159696

Espiard S, Drougat L, Libe R, Assie G, Perlemoine K, Guignat L, Barrande G, Brucker-Davis F, Doullay F, Lopez S, Sonnet E, Torremocha F, Pinsard D, Chabbert-Buffet N, Raffin-Sanson ML, Groussin L, Borson-Chazot F, Coste J, Bertagna X, Stratakis CA, Beuschlein F, Ragazzon B, Bertherat J (2015) ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal Hyperplasia: Clinical and Functional Consequences. J Clin Endocrinol Metab, 2015, 100(6): E926-35. https://doi.org/10.1210/jc.2014-4204

Akaza I, Yoshimoto T, Iwashima F, Nakayama C, Doi M, Izumiyama H, Hirata Y (2011) Clinical outcome of subclinical Cushing’s syndrome after surgical and conservative treatment. Hypertens Res, 2011, 34(10): 1111-5. https://doi.org/10.1038/hr.2011.90

Morelli V, Frigerio S, Aresta C, Passeri E, Pugliese F, Copetti M, Barbieri AM, Fustinoni S, Polledri E, Corbetta S, Arosio M, Scillitani A, Chiodini I (2022) Adrenalectomy Improves Blood Pressure and Metabolic Control in Patients With Possible Autonomous Cortisol Secretion: Results of a RCT. Front Endocrinol (Lausanne), 2022, 13898084. https://doi.org/10.3389/fendo.2022.898084

Perogamvros I, Vassiliadi DA, Karapanou O, Botoula E, Tzanela M, Tsagarakis S (2015) Biochemical and clinical benefits of unilateral adrenalectomy in patients with subclinical hypercortisolism and bilateral adrenal incidentalomas. Eur J Endocrinol, 2015, 173(6): 719–25. https://doi.org/10.1530/EJE-15-0566