Treatment with antidepressant drugs and hyponatremia: a network meta-analysis

Upadhyay A, Jaber BL, Madias NE (2006) Incidence and prevalence of hyponatremia. Am J Med 119:30–35

Article  Google Scholar 

Hoorn EJ, Lindemans J, Zietse R (2006) Development of severe hyponatremia in hospitalized patients: treatment- related risk factors and inadequate management. Nephrol Dial Transpl 21(1):70–76

Article  Google Scholar 

Adrogue HJ, Madias NE, Hyponatremia (2000) N Engl J Med 342(21):1581–1589

Article  CAS  PubMed  Google Scholar 

Ellison DH, Berl T (2007) Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 356(20):2064–2072

Article  CAS  PubMed  Google Scholar 

Corona G, Norello D, Parenti G, Sforza A, Maggi M, Peri A (2018) Hyponatremia, falls and bone fractures: A systematic review and meta-analysis. Clin Endocrinol (Oxf) 89(4):505–513

Article  PubMed  Google Scholar 

Suárez V, Norello D, Sen E, Todorova P, Hackl MJ, Hüser C, Grundmann F, Kubacki T, Becker I, Peri A, Burst V (2020) Impairment of neurocognitive functioning, motor performance, and mood stability in hospitalized patients with euvolemic moderate and profound hyponatremia. Am J Med 133(8):986–993e5

Article  PubMed  Google Scholar 

Norello D, Rastrelli G, Antonio L, Bartfai G, Casanueva FF, Giwercman A, Huhtaniemi IT, O’Neill TW, Punab M, Slowikowska-Hilczer J, Tournoy J, Vanderschueren D, Wu FCW, Maggi M, Peri A (2024) Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains. J Endocrinol Invest 47(4):1005–1014

Article  CAS  PubMed  Google Scholar 

Corona G, Giuliani C, Parenti G, Norello D, Verbalis JG, Forti G, Maggi M, Peri A (2013) Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS ONE 8:e80451

Article  PubMed  PubMed Central  Google Scholar 

Marroncini G, Anceschi C, Naldi L, Fibbi B, Brogi M, Lanzilao L, Fanelli A, Maggi M, Peri A (2023) Hyponatremia-related liver steatofibrosis and impaired spermatogenesis: evidence from a mouse model of the syndrome of inappropriate antidiuresis. J Endocrinol Invest 46(5):967–983

Article  CAS  PubMed  Google Scholar 

Barsony J, Manigrasso MB, Xu Q, Tam H, Verbalis JG (2013) Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats. Age (Dordr) 35(2):271–288

Article  PubMed  Google Scholar 

Sbardella E, Isidori AM, Arnaldi G et al (2018) the: Fluid and Electrolyte Disorders Club of the Italian Society of Endocrinology; Italian Society of Nephrology; and Italian Association of Medical Oncology Approach to hyponatremia according to the clinical setting: consensus statement from the Italian society of endocrinology (SIE), Italian society of nephrology (SIN), and Italian association of medical oncology (AIOM). J Endocrinol Invest 41 1 3–19

Article  CAS  PubMed  Google Scholar 

Liamis G, Milionis H, Elisaf M (2008) A review of drug-induced hyponatremia. Am J Kidney Dis 52(1):144–153

Article  CAS  PubMed  Google Scholar 

Brymer C, Winograd CH (1992) Fluoxetine in elderly patients: is there cause for concern? J Am Geriatr Soc 40(9):902–905

Article  CAS  PubMed  Google Scholar 

Spigset O, Hedenmalm K (1996) Hyponatremia during treatment with Clomipramine, perphenazine, or clozapine: study of therapeutic drug monitoring samples. J Clin Psychopharmacol 16(5):412–414

Article  CAS  PubMed  Google Scholar 

Kirby D, Harrigan S, Ames D (2002) Hyponatraemia in elderly psychiatric patients treated with selective serotonin reuptake inhibitors and Venlafaxine: a retrospective controlled study in an inpatient unit. Int J Geriatr Psychiatry 17(3):231–237

Article  PubMed  Google Scholar 

Movig KL, Leufkens HG, Lenderink AW, Egberts AC (2002) Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly. Eur J Clin Pharmacol 58(2):143–148

Article  CAS  PubMed  Google Scholar 

Chollet F, Tardy J, Albucher JF, Thalamas C, Berard E, Lamy C, Bejot Y, Deltour S, Jaillard A, Niclot P, Guillon B, Moulin T, Marque P, Pariente J, Arnaud C, Loubinoux I (2011) Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol 10(2):123–130

Article  CAS  PubMed  Google Scholar 

Coupland CA, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J (2011) A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database. Health Technol Assess 15(28):1–202

Article  CAS  PubMed  Google Scholar 

Leth-Møller KB, Hansen AH, Torstensson M, Andersen SE, Ødum L, Gislasson G, Torp-Pedersen C, Holm EA (2016) Antidepressants and the risk of hyponatremia: a Danish register-based population study. BMJ Open 6(5):e011200

Article  PubMed  PubMed Central  Google Scholar 

Gandhi S, Shariff SZ, Al-Jaishi A, Reiss JP, Mamdani MM, Hackam DG, Li L, McArthur E, Weir MA, Garg AX (2017) Second-Generation antidepressants and hyponatremia risk: A Population-Based cohort study of older adults. Am J Kidney Dis 69(1):87–96

Article  CAS  PubMed  Google Scholar 

Farmand S, Lindh JD, Calissendorff J, Skov J, Falhammar H, Nathanson D, Mannheimer B (2018) Differences in associations of antidepressants and hospitalization due to hyponatremia. Am J Med 131(1):56–63

Article  CAS  PubMed  Google Scholar 

EFFECTS Trial Collaboration (2020) Safety and efficacy of Fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial. Lancet Neurol 19(8):661–669

Article  Google Scholar 

Fabian TJ, Amico JA, Kroboth PD, Mulsant BH, Reynolds CF 3rd, Pollock BG (2003) Paroxetine-induced hyponatremia in the elderly due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). J Geriatr Psychiatry Neurol 16(3):160–164

Article  PubMed  Google Scholar 

Miller M (2006) Hyponatremia and arginine vasopressin dysregulation: mechanisms, clinical consequences, and management. J Am Geriatr Soc 54(2):345–353

Article  PubMed  Google Scholar 

Wilkinson TJ, Begg EJ, Winter AC, Sainsbury R (1999) Incidence and risk factors for hyponatraemia following treatment with Fluoxetine or Paroxetine in elderly people. Br J Clin Pharmacol 47(2):211–217

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fabian TJ, Amico JA, Kroboth PD, Mulsant BH, Corey SE, Begley AE, Bensasi SG, Weber E, Dew MA, Reynolds CF 3rd, Pollock BG (2004) Paroxetine-induced hyponatremia in older adults. A 12-week prospective study. Arch Intern Med 164(3):327–332

Article  CAS  PubMed  Google Scholar 

Mulrow CD, Williams JW Jr, Chiquette E, Aguilar C, Hitchcock-Noel P, Lee S, Cornell J, Stamm K (2000) Efficacy of newer medications for treating depression in primary care patients. Am J Med 108(1):54–64

Article  CAS  PubMed  Google Scholar 

De Picker L, Van Den Eede F, Dumont G, Moorkens G, Sabbe BG (2014) Antidepressants and the risk of hyponatremia: a class-by-class review of literature. Psychosomatics 55(6):536–547

Article  PubMed  Google Scholar 

Gheysens T, Van Den Eede F, De Picker L (2024) The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds. Eur Psychiatry 67(1):e20

Article  PubMed  PubMed Central  Google Scholar 

Gibbs DM, Vale W (1983) Effect of the serotonin reuptake inhibitor Fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood. Brain Res 280(1):176–179

Article  CAS  PubMed  Google Scholar 

Pérgola PE, Sved AF, Voogt JL, Alper RH (1993) Effect of serotonin on vasopressin release: a comparison to corticosterone, prolactin and Renin. Neuroendocrinology 57(3):550–558

Article  PubMed  Google Scholar 

Jørgensen H, Riis M, Knigge U, Kjaer A, Warberg J (2003) Serotonin receptors involved in vasopressin and Oxytocin secretion. J Neuroendocrinol 15(3):242–249

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