Effects of diabetic ketoacidosis, islet cell function, and age of onset on pancreas size, morphology, and exocrine function in children with type 1 diabetes: an abdominal MRI study

Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464(7293):1293–1300. https://doi.org/10.1038/nature08933

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ilonen J, Lempainen J, Veijola R (2019) The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol 15(11):635–650. https://doi.org/10.1038/s41574-019-0254-y

Article  CAS  PubMed  Google Scholar 

Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E (2019) Structure and function of the exocrine pancreas in patients with type 1 diabetes. Rev Endocr Metab Disord 20(2):129–149. https://doi.org/10.1007/s11154-019-09501-3

Article  PubMed  Google Scholar 

Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS (2012) Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 308(22):2337–2339. https://doi.org/10.1001/jama.2012.15008

Article  CAS  PubMed  Google Scholar 

Campbell-Thompson ML, Kaddis JS, Wasserfall C, Haller MJ, Pugliese A, Schatz DA et al (2016) The influence of type 1 diabetes on pancreatic weight. Diabetologia 59(1):217–221. https://doi.org/10.1007/s00125-015-3752-z

Article  PubMed  Google Scholar 

Augustine P, Gent R, Louise J, Taranto M, Penno M, Linke R et al (2020) Pancreas size and exocrine function is decreased in young children with recent-onset type 1 diabetes. Diabet Med 37(8):1340–1343. https://doi.org/10.1111/dme.13987

Article  CAS  PubMed  Google Scholar 

Jang S, Kim JH, Choi SY, Park SJ, Han JK (2020) Application of computerized 3D-CT texture analysis of pancreas for the assessment of patients with diabetes. PLoS ONE 15(1):e0227492. https://doi.org/10.1371/journal.pone.0227492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Virostko J, Williams J, Hilmes M, Bowman C, Wright JJ, Du L et al (2019) Pancreas volume declines during the first year after diagnosis of type 1 diabetes and exhibits altered diffusion at disease onset. Diabetes Care 42(2):248–257. https://doi.org/10.2337/dc18-1507

Article  CAS  PubMed  Google Scholar 

Williams AJ, Thrower SL, Sequeiros IM, Ward A, Bickerton AS, Triay JM et al (2012) Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes. J Clin Endocrinol Metab 97(11):E2109–E2113. https://doi.org/10.1210/jc.2012-1815

Article  CAS  PubMed  Google Scholar 

Regnell SE, Peterson P, Trinh L, Broberg P, Leander P, Lernmark Å et al (2016) Pancreas volume and fat fraction in children with type 1 diabetes. Diabet Med 33(10):1374–1379. https://doi.org/10.1111/dme.13115

Article  CAS  PubMed  Google Scholar 

Dhatariya KK, Glaser NS, Codner E, Umpierrez GE (2020) Diabetic ketoacidosis. Nat Rev Dis Primers 6(1):40. https://doi.org/10.1038/s41572-020-0165-1

Article  PubMed  Google Scholar 

Virostko J (2020) Quantitative magnetic resonance imaging of the pancreas of individuals with diabetes. Front Endocrinol (Lausanne) 11:592349. https://doi.org/10.3389/fendo.2020.592349

Article  PubMed  Google Scholar 

Domínguez-Muñoz JE, Alvarez-Castro A, Lariño-Noia J, Nieto L, Iglesias-García J (2012) Endoscopic ultrasonography of the pancreas as an indirect method to predict pancreatic exocrine insufficiency in patients with chronic pancreatitis. Pancreas 41(5):724–728. https://doi.org/10.1097/MPA.0b013e31823b5978

Article  PubMed  Google Scholar 

Tirkes T, Fogel EL, Sherman S, Lin C, Swensson J, Akisik F et al (2017) Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis. Abdom Radiol (NY) 42(2):544–551. https://doi.org/10.1007/s00261-016-0917-2

Article  PubMed  Google Scholar 

Tahapary DL, Pratisthita LB, Fitri NA, Marcella C, Wafa S, Kurniawan F et al (2022) Challenges in the diagnosis of insulin resistance: focusing on the role of HOMA-IR and tryglyceride/glucose index. Diabetes Metab Syndr 16(8):102581. https://doi.org/10.1016/j.dsx.2022.102581

Article  CAS  PubMed  Google Scholar 

Wright JJ, Dulaney A, Williams JM, Hilmes MA, Du L, Kang H et al (2023) Longitudinal MRI shows progressive decline in pancreas size and altered pancreas shape in type 1 diabetes. J Clin Endocrinol Metab 108(10):2699–2707. https://doi.org/10.1210/clinem/dgad150

Article  PubMed  PubMed Central  Google Scholar 

Tirkes T, Yadav D, Conwell DL, Territo PR, Zhao X, Persohn SA et al (2023) Diagnosis of chronic pancreatitis using semi-quantitative MRI features of the pancreatic parenchyma: results from the multi-institutional MINIMAP study. Abdom Radiol (NY) 48(10):3162–3173. https://doi.org/10.1007/s00261-023-04000-1

Article  PubMed  Google Scholar 

Al-Mrabeh A, Hollingsworth KG, Steven S, Taylor R (2016) Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity. Diabetologia 59(8):1753–1759. https://doi.org/10.1007/s00125-016-3984-6

Article  PubMed  PubMed Central  Google Scholar 

Macauley M, Percival K, Thelwall PE, Hollingsworth KG, Taylor R (2015) Altered volume, morphology and composition of the pancreas in type 2 diabetes. PLoS ONE 10(5):e0126825. https://doi.org/10.1371/journal.pone.0126825

Article  CAS  PubMed  PubMed Central  Google Scholar 

Virostko J, Wright JJ, Williams JM, Hilmes MA, Triolo TM, Broncucia H et al (2024) Longitudinal assessment of pancreas volume by MRI predicts progression to stage 3 type 1 diabetes. Diabetes Care 47(3):393–400. https://doi.org/10.2337/dc23-1681

Article  PubMed  Google Scholar 

Wright JJ, Williams JM, Letourneau-Freiberg LR, Kandasamy B, Reyes D, Kanegusuku AG et al (2023) Insulin deficiency from insulin gene mutation leads to smaller pancreas. Diabetes Care 46(4):773–776. https://doi.org/10.2337/dc22-2082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silva ME, Vezozzo DP, Ursich MJ, Rocha DM, Cerri GG, Wajchenberg BL (1993) Ultrasonographic abnormalities of the pancreas in IDDM and NIDDM patients. Diabetes Care 16(9):1296–1297. https://doi.org/10.2337/diacare.16.9.1296

Article  CAS  PubMed  Google Scholar 

Nigi L, Maccora C, Dotta F, Sebastiani G (2020) From Immunohistological to anatomical alterations of human pancreas in type 1 diabetes: new concepts on the stage. Diabetes Metab Res Rev 36(4):e3264. https://doi.org/10.1002/dmrr.3264

Article  PubMed  Google Scholar 

Radlinger B, Ramoser G, Kaser S (2020) Exocrine pancreatic insufficiency in type 1 and type 2 diabetes. Curr Diab Rep 20(6):18. https://doi.org/10.1007/s11892-020-01304-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Addio F, Assi E, Maestroni A, Rossi G, Usuelli V, Petrazzuolo A et al (2024) TMEM219 regulates the transcription factor expression and proliferation of beta cells. Front Endocrinol (Lausanne) 15:1306127. https://doi.org/10.3389/fendo.2024.1306127

Article  PubMed  Google Scholar 

Rodriguez-Calvo T, Richardson SJ, Pugliese A (2018) Pancreas pathology during the natural history of type 1 diabetes. Curr Diab Rep 18(11):124. https://doi.org/10.1007/s11892-018-1084-3

Article  PubMed  Google Scholar 

Watanabe H, Kanematsu M, Tanaka K, Osada S, Tomita H, Hara A et al (2014) Fibrosis and postoperative fistula of the pancreas: correlation with MR imaging findings–preliminary results. Radiology 270(3):791–799. https://doi.org/10.1148/radiol.13131194

Article  PubMed  Google Scholar 

Nyenwe EA, Kitabchi AE (2016) The evolution of diabetic ketoacidosis: an update of its etiology, pathogenesis and management. Metabolism 65(4):507–521. https://doi.org/10.1016/j.metabol.2015.12.007

Article  CAS  PubMed  Google Scholar 

Smigoc Schw

Comments (0)

No login
gif