Exposure profiles to Benzophenones and their impacts on thyroid hormones in pregnant women

Korem Kohanim Y, Milo T, Raz M, Karin O, Bar A, Mayo A et al (2022) Dynamics of thyroid diseases and thyroid-axis gland masses. Mol Syst Biol 18(8):e10919

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernal J (2007) Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab 3(3):249–259

Article  CAS  PubMed  Google Scholar 

Kotsopoulou I, Vyas AK, Cory MJ, Chan CS, Jagarapu J, Gill S et al (2022) Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system. J Perinatol 42(12):1576–1586

Article  CAS  PubMed  Google Scholar 

Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C (2017) Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience 342:68–100

Article  CAS  PubMed  Google Scholar 

Brucker-Davis F (1998) Effects of environmental synthetic chemicals on thyroid function. Thyroid 8(9):827–856

Article  CAS  PubMed  Google Scholar 

He J, Xu J, Zheng M, Pan K, Yang L, Ma L et al (2024) Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review. Chemico-Biol Interact 391:110909

Article  CAS  Google Scholar 

Yang Y, Bai X, Lu J, Zou R, Ding R, Hua X (2023) Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis. Front Endocrinol (Lausanne) 14:1283087

Article  PubMed  Google Scholar 

Yilmaz B, Terekeci H, Sandal S, Kelestimur F (2020) Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord 21(1):127–147

Article  CAS  PubMed  Google Scholar 

Monneret C (2017) What is an endocrine disruptor? C R Biol 340(9–10):403–405

Article  PubMed  Google Scholar 

Ouazzani HE, Rouillon S, Venisse N, Sifer-Rivière L, Dupuis A, Cambien G et al (2021) Impact of perinatal environmental health education intervention on exposure to endocrine disruptors during pregnancy-PREVED study: study protocol for a randomized controlled trial. Trials 22(1):876

Article  PubMed  PubMed Central  Google Scholar 

Touhouche S, Guenifed A, Yaker ND, Khelfi A (2023) Phtalates et fonctions reproductrices de la femme: effets réels ou mythes? Toxicologie Analytique et Clinique 36(2): 109-130

Belcher S (2024) Common EDCs and Where They Are Found: Endocrine Society; [Available from: https://www.endocrine.org/topics/edc/what-edcs-are/common-edcs

Sharma S, Surana K, Chaudhary B, Diwaker M (2018) Benzophenone: A ubiquitous scaffold in medicinal chemistry. MedChemComm. 9: 1803-1817

Wnuk W, Michalska K, Krupa A, Pawlak K (2022) Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women? Postepy Dermatol Alergol. 39(1):26–33

Silano V, Bolognesi C, Castle L, Chipman K, Cravedi J-P, Engel KH et al (2017) Safety of benzophenone to be used as flavouring. EFSA J. 15(11):1-33

Huang T-L, Chen Y-C (2022) Synthesis and free radical photopolymerization of one-component type II photoinitiator based on benzophenone segment. J Photochem Photobiol A 429:113900

Article  CAS  Google Scholar 

Krause M, Klit A, Blomberg Jensen M, Søeborg T, Frederiksen H, Schlumpf M et al (2012) Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. Int J Androl 35(3):424–436

Article  CAS  PubMed  Google Scholar 

Muncke J (2011) Endocrine disrupting chemicals and other substances of concern in food contact materials: an updated review of exposure, effect and risk assessment. J Steroid Biochem Mol Biol 127(1–2):118–127

Article  CAS  PubMed  Google Scholar 

Song S, He Y, Huang Y, Huang X, Guo Y, Zhu H et al (2020) Occurrence and transfer of benzophenone-type ultraviolet filters from the pregnant women to fetuses. Sci Total Environ 726:138503

Article  CAS  PubMed  Google Scholar 

Broniowska Ż, Pomierny B, Smaga I, Filip M, Budziszewska B (2016) The effect of UV-filters on the viability of neuroblastoma (SH-SY5Y) cell line. Neurotoxicology 54:44–52

Article  CAS  PubMed  Google Scholar 

Fu J, Yao Y, Huang Z, Huang J, Zhang D, Li X et al (2024) Prenatal exposure to benzophenone-type UV filters and the associations with neonatal birth outcomes and maternal health in South China. Environ Int 189:108797

Article  CAS  PubMed  Google Scholar 

Henkel R (2018) Chapter 12 - Environmental contamination and testicular function. In: Sikka SC, Hellstrom WJG (eds) Bioenvironmental issues affecting Men’s reproductive and sexual health. Academic, Boston, pp 191–208

Chapter  Google Scholar 

Marotta V, Grumetto L, Neri I, Russo G, Tortora A, Izzo G et al (2023) Exposure to bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environ Pollut 316(Pt 1):120478

Article  CAS  PubMed  Google Scholar 

Coperchini F, Croce L, Ricci G, Magri F, Rotondi M, Imbriani M et al (2020) Thyroid disrupting effects of old and new generation PFAS. Front Endocrinol (Lausanne) 11:612320

Article  PubMed  Google Scholar 

Duntas LH, Chiovato L (2025) Editorial: thyroid endocrine disruptors. Front Endocrinol. 16: 1-2

Maia A, Vieira-Coelho MA (2024) The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review. Eur J Pediatr 184(1):111

Article  PubMed  Google Scholar 

Jiménez-Díaz I, Artacho-Cordón F, Vela-Soria F, Belhassen H, Arrebola JP, Fernández MF et al (2016) Urinary levels of bisphenol A, benzophenones and Parabens in Tunisian women: A pilot study. Sci Total Environ 562:81–88

Article  PubMed  Google Scholar 

Krause M, Frederiksen H, Sundberg K, Jørgensen F, Jensen L, Nørgaard P et al (2018) Maternal exposure to UV filters and associations to maternal thyroid hormones and IGF-I/IGFBP3 and birth outcomes. Endocr Connections 7:EC–17

Article  Google Scholar 

Kunisue T, Wu Q, Tajima Y, Aldous K (2010) Analysis of five benzophenone-type UV filters in human urine by liquid chromatography-tandem mass spectrometry. Anal Methods 2: 707-713

Kang H, Kim S, Lee G, Lee I, Lee JP, Lee J et al (2019) Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women. Environ Int 124:354–360

Article  CAS  PubMed  Google Scholar 

Wang L (2013) Characteristic profiles of Benzonphenone-3 and its derivatives in urine of children and adults from the united States and China, vol 47. Environmental science & technology

Google Scholar 

Guo J, Wu C, Zhang J, Li W, Lv S, Lu D et al (2020) Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: the SMBCS study. Sci Total Environ 743:140678

Article  CAS  PubMed  Google Scholar 

Berger K, Gunier RB, Chevrier J, Calafat AM, Ye X, Eskenazi B et al (2018) Associations of maternal exposure to triclosan, Parabens, and other phenols with prenatal maternal and neonatal thyroid hormone levels. Environ Res 165:379–386

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aker AM, Johns L, McElrath TF, Cantonwine DE, Mukherjee B, Meeker JD (2018) Associations between maternal phenol and Paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environ Int 113:341–349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang R, Chen M-j, Ding G-d, Chen X-j, Han X-m, Zhou K et al (2013) Associations of prenatal exposure to phenols with birth outcomes. Environ Pollut 178:115–120

Article  CAS  PubMed  Google Scholar 

Philippat C, Mortamais M, Chevrier C, Petit C, Calafat A, Ye X et al (2011) Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environ Health Perspect 120:464–470

Article  PubMed  PubMed Central  Google Scholar 

Derakhshan A, Shu H, Broeren MAC, Lindh CH, Peeters RP, Kortenkamp A et al (2021) Association of phthalate exposure with thyroid function during pregnancy. Environ Int 157:106795

Article  CAS  PubMed  Google Scholar 

Huang H, Liang J, Tang P, Yu C, Fan H, Liao Q et al (2022) Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China. Environ Sci Pollut Res Int 29(58):87170–87183

Article  CAS 

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