Katz JN, Arant KR, Loeser RF (2021) Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA 325(6):568–578. https://doi.org/10.1001/jama.2020.22171

Article  PubMed  PubMed Central  CAS  Google Scholar 

Clémence P, Christelle N, Marie-Martine L-C, François R, Serge P (2016) Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med 59(3):134–138. https://doi.org/10.1016/j.rehab.2016.01.006

Article  Google Scholar 

He Y, Li Z, Alexander PG, Ocasio-Nieves BD, Yocum L, Lin H et al (2000) Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models. Biology (Basel) 9(8):194. https://doi.org/10.3390/biology9080194

Sayer AA, Cruz-Jentoft A (2022) Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing 51(10):afac220. https://doi.org/10.1093/ageing/afac220

Article  PubMed  PubMed Central  Google Scholar 

Belluzzi E, Macchi V, Fontanella CG, Carniel EL, Olivotto E, Filardo G et al (2020) Infrapatellar fat pad gene expression and protein production in patients with and without osteoarthritis. Int J Mol Sci 21(17):6016. https://doi.org/10.3390/ijms21176016

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu B, Wang Z, Fu J, Guan H, Lyu Z, Wang W (2021) Sensitivity to thyroid hormones and risk of prediabetes: a cross-sectional study. Front Endocrinol (Lausanne) 12:657114. https://doi.org/10.3389/fendo.2021.657114

Article  PubMed  Google Scholar 

Chen S, Sun X, Zhou G, Jin J, Li Z (2022) Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study. Eur J Med Res 27(1):114. https://doi.org/10.1186/s40001-022-00749-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

McDermott MT (2020) Hyperthyroidism. Ann Intern Med 172(7):ITC49TC64. https://doi.org/10.7326/AITC202004070

Garmendia Madariaga A, Santos Palacios S, Guillen-Grima F, Galofre JC (2014) The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis. J Clin Endocrinol Metab 99(3):923–931. https://doi.org/10.1210/jc.2013-2409PubMed PMID: 24423323

Article  PubMed  CAS  Google Scholar 

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA et al (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87(2):489–499. https://doi.org/10.1210/jcem.87.2.8182

Article  PubMed  CAS  Google Scholar 

Kim BY, Kim SS, Park HK, Kim HS (2020) Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction. J Int Med Res 48(1):300060519897701. https://doi.org/10.1177/0300060519897701

Article  PubMed  Google Scholar 

Bayliss LE, Culliford D, Monk AP, Glyn-Jones S, Prieto-Alhambra D, Judge A et al (2017) The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study. Lancet 389(10077):1424–1430. https://doi.org/10.1016/S0140-6736(17)30059-4

Article  PubMed  PubMed Central  Google Scholar 

C E C, T E M, D T F AN, P W W, C T S (1996) Lack of association between thyroid status and chondrocalcinosis or osteoarthritis: the Framingham osteoarthritis study. J Rheumatol 23(4):711–715

Google Scholar 

Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: a review. Res Synth Methods 10(4):486–496. https://doi.org/10.1002/jrsm.1346

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Small DS, Thompson SG (2017) A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res 26(5):2333–2355. https://doi.org/10.1177/0962280215597579

Article  PubMed  Google Scholar 

Zhang L, Zhang C, Zhang J, Liu A, Wang P, Xu J (2023) A bidirectional Mendelian randomization study of sarcopenia-related traits and knee osteoarthritis. Clin Interv Aging 18:1577–1586. https://doi.org/10.2147/CIA.S424633

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu J, Zhang S, Tian Y, Si H, Zeng Y, Wu Y et al (2022) Genetic causal association between iron status and osteoarthritis: a two-sample Mendelian randomization. Nutrients 14(18):3683. https://doi.org/10.3390/nu14183683

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhao SS, Karhunen V, Morris AP, Gill D (2022) ADAMTS5 as a therapeutic target for osteoarthritis: Mendelian randomisation study. Ann Rheum Dis 81(6):903–904. https://doi.org/10.1136/annrheumdis-2021-222007

Article  PubMed  Google Scholar 

Chen L, Jia C, Yang H (2023) Causal effect of higher glycated hemoglobin (HbA1c) levels on knee osteoarthritis risk: a Mendelian randomization study. Rheumatol Ther 10(1):239–247. https://doi.org/10.1007/s40744-022-00510-4

Article  PubMed  Google Scholar 

Funck-Brentano T, Nethander M, Moverare-Skrtic S, Richette P, Ohlsson C (2019) Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK biobank. Arthritis Rheumatol 71(10):1634–1641. https://doi.org/10.1002/art.40928

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin L, Luo P, Yang M, Wang J, Hou W, Xu P (2022) Causal relationship between osteoporosis and osteoarthritis: a two-sample Mendelian randomized study. Front Endocrinol (Lausanne) 13:1011246. https://doi.org/10.3389/fendo.2022.1011246

Article  PubMed  Google Scholar 

Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z et al (2023) Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample Mendelian randomization study. J Transl Med 21(1):357. https://doi.org/10.1186/s12967-023-04165-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S et al (2021) A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 53(10):1415–1424. https://doi.org/10.1038/s41588-021-00931-x

Article  PubMed  CAS  Google Scholar 

Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, Zheng J et al (2019) Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK biobank data. Nat Genet 51(2):230–236. https://doi.org/10.1038/s41588-018-0327-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG, Consortium E-I (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543–552. https://doi.org/10.1007/s10654-015-0011-z

Article  PubMed  PubMed Central  Google Scholar 

Hartwig FP, Davies NM, Hemani G, Davey Smith G (2016) Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique. Int J Epidemiol 45(6):1717–1726. https://doi.org/10.1093/ije/dyx028

Article  PubMed  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304–314. https://doi.org/10.1002/gepi.21965

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Tilling K, Davey Smith G (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13(11):e1007081. https://doi.org/10.1371/journal.pgen.1007081

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dyrek N, Wikarek A, Niemiec M, Kocelak P (2023) Selected musculoskeletal disorders in patients with thyroid dysfunction, diabetes, and obesity. Reumatologia 61(4):305–317. https://doi.org/10.5114/reum/170312

Article  PubMed  PubMed Central  Google Scholar 

Sachs LM, Buchholz DR (2017) Frogs model man: in vivo thyroid hormone signaling during development. Genesis 55(1–2). https://doi.org/10.1002/dvg.23000