Al-Maghrebi M, Alnajem AS, Esmaeil A (2020) Epigallocatechin-3-gallate modulates germ cell apoptosis through the SAFE/Nrf2 signaling pathway. Naunyn Schmiedebergs Arch Pharmacol 393:663–671. https://doi.org/10.1007/s00210-019-01776-2

Article  CAS  PubMed  Google Scholar 

Moreira MA, Irigoyen MC, Saad KR et al (2016) N-acetylcysteine reduces the renal oxidative stress and apoptosis induced by hemorrhagic shock. J Surg Res 203:113–120. https://doi.org/10.1016/j.jss.2016.02.020

Article  CAS  PubMed  Google Scholar 

Chen M, Li X, Mu G (2022) Myocardial protective and anti-inflammatory effects of dexmedetomidine in patients undergoing cardiovascular surgery with cardiopulmonary bypass: a systematic review and meta-analysis. J Anesth 36:5–16. https://doi.org/10.1007/s00540-021-02982-0

Article  PubMed  Google Scholar 

Tanyeli A, Guzel Erdogan D, Comakli S et al (2022) Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury. Biotech Histochem 00:1–10. https://doi.org/10.1080/10520295.2022.2036368

Article  CAS  Google Scholar 

Xiao J, Wan W, Zhang Y et al (2021) Administration of dexmedetomidine does not produce long-term protective effect on testicular damage post testicular ischemia-reperfusion injury. Drug Des Devel Ther 15:315–321. https://doi.org/10.2147/DDDT.S293926

Article  PubMed  PubMed Central  Google Scholar 

Tuglu D, Yuvanc E, Yılmaz E et al (2015) The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury. Acta Cir Bras 30:414–421. https://doi.org/10.1590/S0102-865020150060000007

Article  PubMed  Google Scholar 

Heidarizadi S, Rashidi Z, Jalili C, Gholami M (2022) Overview of biological effects of melatonin on testis: A review. Andrologia 54:e14597. https://doi.org/10.1111/and.14597

Article  CAS  PubMed  Google Scholar 

Al-Maghrebi M, Renno WM, Al-Ajmi N (2012) Epigallocatechin-3-gallate inhibits apoptosis and protects testicular seminiferous tubules from ischemia/reperfusion-induced inflammation. Biochem Biophys Res Commun 420:434–439. https://doi.org/10.1016/j.bbrc.2012.03.013

Article  CAS  PubMed  Google Scholar 

Pan S, Chen Y, Zhang X, Xie Y (2020) The JAK2/STAT3 pathway is involved in dexmedetomidine-induced myocardial protection in rats undergoing cardiopulmonary bypass. Ann Transl Med 8:483–483. https://doi.org/10.21037/atm.2020.03.67

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurt A, Kalkan Y, Turut H et al (2018) Topiramate reduces aortic cross-clamping-induced lung injury in male rats. Acta Med (Hradec Kralove, Czech Repub) 61:144–149. https://doi.org/10.14712/18059694.2018.133

Article  CAS  Google Scholar 

Koçyiğit A, Gülmen Ş, Kurtoğlu T et al (2018) The effect of ozone treatment on remote organ myocardial injury in an aortic ischemia-reperfusion model. Turkish J Thorac Cardiovasc Surg 26:207–213. https://doi.org/10.5606/tgkdc.dergisi.2018.15484

Article  Google Scholar 

El-Sisi AEDES, Sokar SS, Shebl AM et al (2021) Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury. Toxicol Appl Pharmacol 410:115340. https://doi.org/10.1016/j.taap.2020.115340

Article  CAS  PubMed  Google Scholar 

Wang TL, Huang YH, Chang H (2005) Somatostatin analogue mimics acute ischemic preconditioning in a rat model of myocardial infarction. J Cardiovasc Pharmacol 45:327–332. https://doi.org/10.1097/01.fjc.0000156823.35210.21

Article  CAS  PubMed  Google Scholar 

Yakusheva A, Titchenko N, Egorova B et al (2019) From octreotide to shorter analogues: Synthesis, radiolabeling, stability. J Label Compd Radiopharm 62:718–728. https://doi.org/10.1002/jlcr.3799

Article  CAS  Google Scholar 

Kalyoncu S, Yilmaz B, Demir M et al (2020) Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress. J Obstet Gynaecol Res 46:2050–2058. https://doi.org/10.1111/jog.14379

Article  CAS  PubMed  Google Scholar 

Olesen HØ, Pors SE, Jensen LB et al (2021) N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue. Hum Reprod 36:429–443. https://doi.org/10.1093/humrep/deaa291

Article  CAS  PubMed  Google Scholar 

Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Hurst V, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H (2020) Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol 18(7):e3000411. https://doi.org/10.1371/journal.pbio.3000411

Johnson PD, Besselsen DG (2002) Practical aspects of experimental design in animal research. ILAR J 43:202–206. https://doi.org/10.1093/ilar.43.4.202

Article  CAS  PubMed  Google Scholar 

Charan J, Kantharia N (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4:303–306. https://doi.org/10.4103/0976-500X.119726

Article  PubMed  PubMed Central  Google Scholar 

Mercantepe F, Tumkaya L, Mercantepe T et al (2023) The effects of dexmedetomidine on abdominal aortic occlusion-induced ovarian injury via oxidative stress and apoptosis. Cells Tissues Organs 212:554–566. https://doi.org/10.1159/000531613

Article  CAS  PubMed  Google Scholar 

Unsal V, Kurutaş EB (2020) Investigation of the effects of octreotide agent on oxidative stress, 8-hydroxy deoxyguanosine in experimental hepatic carcinogenesis rat model. Folia Med 62:70–75. https://doi.org/10.3897/folmed.62.e47735

Article  CAS  Google Scholar 

Ayala TB, Sathyasaikumar KV, Uys JD et al (2021) N-Acetylcysteine Inhibits Kynurenine Aminotransferase II. Neuroscience 444:160–169. https://doi.org/10.1016/j.neuroscience.2020.07.049.N-Acetylcysteine

Article  Google Scholar 

Vukovic R, Kumburovic I, Jovic JJ et al (2019) N-acetylcysteine protects against the anxiogenic response to cisplatin in rats. Biomolecules 9:1–15. https://doi.org/10.3390/biom9120892

Article  CAS  Google Scholar 

Jiang D, Wu D, Zhang Y et al (2012) Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol 187:2249–2253. https://doi.org/10.1016/j.juro.2012.01.029

Article  CAS  PubMed  Google Scholar 

Sönmez M, Ozdemir GM, Kaymak E (2017) The ameliorative effects of vinpocetine on apoptosis and HSP-70 expression in testicular torsion in rats. Biotech Histochem 92:92–99. https://doi.org/10.1080/10520295.2016.1259499

Article  CAS  PubMed  Google Scholar 

Johnsen SG (1970) Testicular biopsy score count – a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2–25. https://doi.org/10.1159/000178170

Article  CAS  PubMed  Google Scholar 

Mete F, Tarhan H, Celik O et al (2017) Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats. Asian J Androl 19:43–46. https://doi.org/10.4103/1008-682X.171570

Article  PubMed  Google Scholar 

Vasankari T, Kujala U, Taimela S et al (1995) Effects of a long acting somatostatin analog on pituitary, adrenal, and testicular function during rest and acute exercise: unexpected stimulation of testosterone secretion. J Clin Endocrinol Metab 80:2–7

Google Scholar 

Aurich JE, Kranski S, Parvizi N, Aurich C (2003) Somatostatin treatment affects testicular function in stallions. Theriogenology 60:163–174. https://doi.org/10.1016/S0093-691X(02)01361-4

Article  CAS  PubMed  Google Scholar 

Ekinci Akdemir FN, Yildirim S, Kandemir FM et al (2019) The antiapoptotic and antioxidant effects of eugenol against cisplatin-induced testicular damage in the experimental model. Andrologia 51:1–8. https://doi.org/10.1111/and.13353

Article  CAS  Google Scholar 

Yadav YC (2019) Effect of cisplatin on pancreas and testies in Wistar rats: biochemical parameters and histology. Heliyon 5:e02247. https://doi.org/10.1016/j.heliyon.2019.e02247

Article