Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013;32(3–4):643–71. https://doi.org/10.1007/s10555-013-9444-6.

Article  CAS  PubMed  Google Scholar 

Blumenthal RD, Hansen HJ, Goldenberg DM. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Can Res. 2005;65(19):8809–17. https://doi.org/10.1158/0008-5472.CAN-05-0420.

Article  CAS  Google Scholar 

Blumenthal RD, Leon E, Hansen HJ, Goldenberg DM. Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BMC Cancer. 2007;7:2. https://doi.org/10.1186/1471-2407-7-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Booth SN, Jamieson GC, King JP, Leonard J, Oates GD, Dykes PW. Carcinoembryonic antigen in management of colorectal carcinoma. BMJ. 1974;4(5938):183–7. https://doi.org/10.1136/bmj.4.5938.183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buikhuisen JY, Torang A, Medema JP. Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges. Oncogenesis. 2020;9(7):66. https://doi.org/10.1038/s41389-020-00250-6.

Article  PubMed  PubMed Central  Google Scholar 

Burtin P, Gold P, Chu TM. Carcinoembryonic antigen. Scand J Immunol. 1978;8(Suppl 8):27–38.

CAS  Google Scholar 

Chen CC, Yang SH, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS, Chang SC. Is it reasonable to add preoperative serum level of CEA and CA19-9 to staging for colorectal cancer? J Surg Res. 2005;124(2):169–74. https://doi.org/10.1016/j.jss.2004.08.013.

Article  CAS  PubMed  Google Scholar 

Cho S, Shin A, Park SK, Shin HR, Chang SH, Yoo KY. Alcohol drinking, cigarette smoking and risk of colorectal cancer in the korean multi-center cancer cohort. J Cancer Prevent. 2015;20(2):147–52. https://doi.org/10.15430/JCP.2015.20.2.147.

Article  Google Scholar 

Giuliante F, Panettieri E, Ardito F, De Rose A, Pocino K, Autilio C, Paolillo C, Capoluongo ED. Circulating tumor cell-related transcripts in blood as prognostic biomarkers of early recurrence after liver resection for colorectal metastases. Int J Biol Markers. 2019;34(3):269–75. https://doi.org/10.1177/1724600819849438.

Article  CAS  PubMed  Google Scholar 

Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121(3):439–62. https://doi.org/10.1084/jem.121.3.439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu S, Zaidi S, Hassan MI, Mohammad T, Malta TM, Noushmehr H, Nguyen B, Crandall KA, Srivastav J, Obias V, Lin P, Nguyen BN, Yao M, Yao R, King CH, Mazumder R, Mishra B, Rao S, Mishra L. Mutated CEACAMs disrupt transforming growth factor beta signaling and alter the intestinal microbiome to promote colorectal carcinogenesis. Gastroenterology. 2020;158(1):238–52. https://doi.org/10.1053/j.gastro.2019.09.023.

Article  CAS  PubMed  Google Scholar 

Hamada T, Nowak JA, Masugi Y, Drew DA, Song M, Cao Y, Kosumi K, Mima K, Twombly TS, Liu L, Shi Y, da Silva A, Gu M, Li W, Nosho K, Keum N, Giannakis M, Meyerhardt JA, Wu K, Wang M, et al. Smoking and risk of colorectal cancer sub-classified by tumor-infiltrating T cells. J Natl Cancer Inst. 2019;111(1):42–51. https://doi.org/10.1093/jnci/djy137.

Article  CAS  PubMed  Google Scholar 

Hanke B, Riedel C, Lampert S, Happich K, Martus P, Parsch H, Himmler B, Hohenberger W, Hahn EG, Wein A. CEA and CA 19–9 measurement as a monitoring parameter in metastatic colorectal cancer (CRC) under palliative first-line chemotherapy with weekly 24-hour infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA). Ann Oncol Off J Eur Soc Med Oncol. 2001;12(2):221–6. https://doi.org/10.1023/a:1008378412533.

Article  CAS  Google Scholar 

Hauptman N, Glavač D. Colorectal cancer blood-based biomarkers. Gastroenterol Res Pract. 2017;2017:2195361. https://doi.org/10.1155/2017/2195361.

Article  PubMed  PubMed Central  Google Scholar 

Hostetter RB, Augustus LB, Mankarious R, Chi KF, Fan D, Toth C, Thomas P, Jessup JM. Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis. J Natl Cancer Inst. 1990;82(5):380–5. https://doi.org/10.1093/jnci/82.5.380.

Article  CAS  PubMed  Google Scholar 

Hundt S, Haug U, Brenner H. Blood markers for early detection of colorectal cancer: a systematic review. Cancer Epidemiol Biomark Prevent A Public Am Assoc Cancer Res Cospons Am Soc Prevent Oncol. 2007;16(10):1935–53. https://doi.org/10.1158/1055-9965.EPI-06-0994.

Article  CAS  Google Scholar 

Jiao Z, Cao S, Li J, Hu N, Gong Y, Wang L, Jin S. Clinical associations of preoperative and postoperative serum CEA and lung cancer outcome. Front Mol Biosci. 2021;8: 686313. https://doi.org/10.3389/fmolb.2021.686313.

Article  PubMed  PubMed Central  Google Scholar 

Kahi CJ, Anderson JC, Rex DK. Screening and surveillance for colorectal cancer: state of the art. Gastrointest Endosc. 2013;77(3):335–50. https://doi.org/10.1016/j.gie.2013.01.002.

Article  PubMed  Google Scholar 

Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X, Cai S. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis. Int J Biol Sci. 2018;14(7):726–35. https://doi.org/10.7150/ijbs.24505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Livingstone AS, Hampson LG, Shuster J, Gold P, Hinchey EJ. Carcinoembryonic antigen in the diagnosis and management of colorectal carcinoma. Curr Status Arch Surg (Chicago, Ill: 1960). 1974;109(2):259–64. https://doi.org/10.1001/archsurg.1974.01360020119023.

Article  CAS  Google Scholar 

Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, Somerfield MR, Hayes DF, Bast RC Jr, ASCO. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(33):5313–27. https://doi.org/10.1200/JCO.2006.08.2644.

Article  CAS  Google Scholar 

Loewenstein MS, Zamcheck N. Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states. Cancer. 1978;42(3 Suppl):1412–8. https://doi.org/10.1002/1097-0142(197809)42:3+%3c1412::aid-cncr2820420805%3e3.0.co;2-8.

Article  CAS  PubMed  Google Scholar 

Mohd Y, Balasubramanian B, Meyyazhagan A, Kuchi Bhotla H, Shanmugam SK, Ramesh Kumar MK, Pappusamy M, Alagamuthu KK, Keshavarao S, Arumugam VA. Extricating the association between the prognostic factors of colorectal cancer. J Gastrointest Cancer. 2021;52(3):1022–8. https://doi.org/10.1007/s12029-020-00535-4.

Article  PubMed  Google Scholar 

Mohd Y, Kumar P, Kuchi Bhotla H, Meyyazhagan A, Balasubramanian B, Ramesh Kumar MK, et al. Transmission jeopardy of adenomatosis polyposis coli and methylenetetrahydrofolate reductase in colorectal cancer. J Renin Angiotensin Aldosterone Syst. 2021;2021:7010706.

Article  PubMed  PubMed Central  Google Scholar 

Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S. A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification. Am J Epidemiol. 2013;178(1):84–100. https://doi.org/10.1093/aje/kws431.

Article  PubMed  PubMed Central  Google Scholar 

Okumura R, Takeda K. Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Exp Mol Med. 2017;49(5): e338. https://doi.org/10.1038/emm.2017.20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pakdel A, Malekzadeh M, Naghibalhossaini F. The association between preoperative serum CEA concentrations and synchronous liver metastasis in colorectal cancer patients. Cancer Biomark Sect A Disease Mark. 2016;16(2):245–52. https://doi.org/10.3233/CBM-150561.

Article  CAS  Google Scholar 

Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal cancer screening: recommendations for physicians and patients from the US multi-society task force on colorectal cancer. Gastroint Endosc. 2017;86(1):18–33. https://doi.org/10.1016/j.gie.2017.04.003.