Does a gentamicin-coated intramedullary nail prevent postoperative infection in Gustilo type I and II tibial open fractures? A comparative study and retrospective analysis

McBirnie J. The epidemiology of tibial fractures. J Bone Joint Surg Br Vol. 1995;77(3):417–21.

Google Scholar 

Wennergren D, Bergdahl C, Ekelund J, Juto H, Sundfeldt M, Möller M. Epidemiology and incidence of tibia fractures in the Swedish fracture Register. Injury. 2018;49(11):2068–74.

Article  PubMed  Google Scholar 

Miller NC, Askew AE. Tibia fractures: an overview of evaluation and treatment. Orthop Nurs. 2007;26(4):216–23.

Article  PubMed  Google Scholar 

Tsukayama DT. (1999). Pathophysiology of posttraumatic osteomyelitis. Clinical Orthopaedics and Related Research (1976–2007), 360, 22–29.

Maurer DJ, Merkow RL, Gustilo RB. Infection after intramedullary nailing of severe open tibial fractures initially treated with external fixation. J Bone Joint Surg Am Vol. 1989;71(6):835–8.

Article  CAS  Google Scholar 

Hofmann A, Dietz SO, Pairon P, Rommens PM. The role of intramedullary nailing in treatment of open fractures. Eur J Trauma Emerg Surg. 2015;41(1):39–47.

Article  CAS  PubMed  Google Scholar 

Fuchs T, Stange R, Schmidmaier G, Raschke MJ. The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study. Arch Orthop Trauma Surg. 2011;131(10):1419–25.

Article  PubMed  PubMed Central  Google Scholar 

Metsemakers WJ, Reul M, Nijs S. The use of gentamicin-coated nails in complex open tibia fracture and revision cases: a retrospective analysis of a single centre case series and review of the literature. Injury. 2015;46(12):2433–7.

Article  CAS  PubMed  Google Scholar 

Alıç T, Hassa E. Open fractures from Gustilo and Anderson to the present: a bibliometric analysis with global productivity and research trends. Indian J Orthop. 2022;56(12):2119–32.

Article  PubMed  PubMed Central  Google Scholar 

SAVCI U, Taner AL, I. Ç., Güreser AS, Özkan AT. Wound infections after orthopedic surgery: distribution of microorganisms and their resistance status. Middle East J Med. 2018;10(4):492–7.

Google Scholar 

Gustilo RB, Merkow RL, Templeman D. The management of open fractures. J Bone Joint Surg Am. 1990;72(2):299–304. (PMID: 2406275).

Article  CAS  PubMed  Google Scholar 

Carver DC, Kuehn SB, Weinlein JC. Role of systemic and local antibiotics in the treatment of open fractures. Orthop Clin North Am. 2017;48:137–53.

Article  PubMed  Google Scholar 

Chen AF, Schreiber VM, Washington W, Rao N, Evans AR. What is the rate of methicillin-resistant Staphylococcus aureus and gram-negative infections in open fractures? Clinical orthopaedics and related research. New York LLC: Springer; 2013. pp. 3135–40.

Google Scholar 

Saveli CC, Belknap RW, Morgan SJ, Price CS. The role of prophylactic antibiotics in open fractures in an era of community-acquired methicillin-resistant Staphylococcus aureus. Orthopedics. 2011;34(8):611–6. https://doi.org/10.3928/01477447-20110627-25. quiz 617.

Article  PubMed  Google Scholar 

Hoff WS, Bonadies JA, Cachecho R, Dorlac WC. (2011) East practice management guidelines work group: update to practice management guidelines for prophylactic antibiotic use in open fractures. J. Trauma–Injury, Infect Crit Care 70:751–754.

Berriós-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152:784–91.

Article  PubMed  Google Scholar 

Robinson D, On E, Hadas N, Halperin N, Hofman S, Boldur I. Microbiologic flora contaminating open fractures: its significance in the choice of primary antibiotic agents and the likelihood of deep wound infection. J Orthop Trauma. 1989;3:283–6.

Article  CAS  PubMed  Google Scholar 

Chapman MW. Open Fractures. In: Chapman MW, editor. Operative Orthopaedics. 2nd Edition. Philadelphia: JB Lippincott Company 1993:365–372.

Steiner AK, Kotisso B. Open fractures and internal fixation in a major African hospital. Injury. 1996;27:625–30.

Article  CAS  PubMed  Google Scholar 

Dellinger EP, Caplan ES, Weaver LD, et al. Duration of preventive antibiotic administration for open extremity fractures. Arch Surg. 1988;123:333–9.

Article  CAS  PubMed  Google Scholar 

Patzakis MJ, Wilkins J. Factors influencing infection rate in open fracture wounds. Clin Orthop. 1989;243:36–40.

Article  Google Scholar 

Bergman BR. Antibiotic prophylaxis in open and closed fractures: a controlled trial. Acta Orthop Scand. 1982;53:57–62.

Article  CAS  PubMed  Google Scholar 

Bednar DA, Parikh J. Effect of time delay from injury to primary management on the incidence of deep infection after open fractures of the lower extremities caused by blunt trauma in adults. J Orthop Trauma. 1993;7:532–5.

Article  CAS  PubMed  Google Scholar 

Dellinger EP. Antibiotic prophylaxis in trauma: penetrating abdominal injuries and open fractures. Rev Infect Dis. 1991;13:S847–857.

Article  PubMed  Google Scholar 

Whelan DB, Bhandari M, Stephen D, Kreder H, McKee MD, Zdero R, Schemitsch EH. Development of the radiographic union score for tibial fractures for the assessment of tibial fracture healing after intramedullary fixation. J Trauma Acute Care Surg. 2010;68(3):629–32.

Article  Google Scholar 

United States Food and Drug Administration (USFDA). Office of Device Evaluation, Guidance Document for Industry and CDRH Staff for the Preparation of Investigational device exemptions. and Premarket Approval Application for Bone Growth Stimulator Devices; 1988.

Abboud A, Masrouha K, Hanna T, Saghieh S. Union following biological and rigid fixations of distal tibia extra-articular fractures. Arch Bone Jt Surg. 2020;8(2):162–7. https://doi.org/10.22038/abjs.2019.36760.1972. PMID: 32490046; PMCID: PMC7191982.

Article  PubMed  PubMed Central  Google Scholar 

Ware JE Jr. SF-36 health survey update. Spine. 2000;25(24):3130–9.

Article  PubMed  Google Scholar 

Binkley JM, Stratford PW, Lott SA, Riddle DL, North American Orthopaedic Rehabilitation Research Network. The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application. Phys Ther. 1999;79(4):371–83.

CAS  PubMed  Google Scholar 

Keating JF, O’brien PJ, Blachut PA, Meek RN, Broekhuyse HM. Locking intramedullary nailing with and without reaming for open fractures of the tibial shaft. A prospective, randomized study. JBJS. 1997;79(3):334–41.

Article  CAS  Google Scholar 

Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Börner MG, Chiron P. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. JBJS. 2002;84(12):2123–34.

Article  Google Scholar 

Davis BJ, Roberts PJ, Moorcroft CI, Brown MF, Thomas PB, Wade RH. Reliability of radiographs in defining union of internally fixed fractures. Injury. 2004;35(6):557–61.

Article  CAS  PubMed  Google Scholar 

Johnson EE, Urist MR, Finerman GA. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein. A preliminary report. Clin Orthop Relat Res. 1988;236:249–57. [PubMed] [CrossRef] [Google Scholar].

Article  Google Scholar 

Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M. Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury. 2006;37(2):S105–12.

Article  PubMed  Google Scholar 

Kristensen KD. Tibial shaft fractures: the frequency of local complications in tibial shaft fractures treated by internal compression osteosynthesis. Acta Orthop Scand. 1979;50(5):593–8.

Article  CAS  PubMed  Google Scholar 

Calhoun JH, Mader JT. Treatment of osteomyelitis with a biodegradable antibiotic implant. Clin Orthop Relat Res. 1997;341:206–14.

Article  Google Scholar 

Raschke M, Vordemvenne T, Fuchs T. Limb salvage or amputation? The use of a gentamicin coated nail in a severe, grade IIIc tibia fracture. Eur J Trauma Emerg Surg. 2010;36(6):605–8.

Article  CAS  PubMed  Google Scholar 

Meo D, Cannari D, Petriello FM, Persiani L, P., Villani C. Gentamicin-coated tibia nail in fractures and nonunion to reduce fracture-related infections: a systematic review. Molecules. 2020;25(22):5471.

Gaebler, C., Berger, U., Schandelmaier, P., Greitbauer, M., Schauwecker, H. H., Applegate,B.,… & Vecsei, V. (2001). Rates and odds ratios for complications in closed and open tibial fractures treated with unreamed, small diameter tibial nails: a multicenter analysis of 467 cases. Journal of orthopaedic trauma, 15(6), 415–423.

Schmidmaier G, Wildemann B, Stemberger A, Haas NP, Raschke M. Biodegradable poly (D, L-lactide) coating of implants for continuous release of growth factors. J Biomedical Mater Research: Official J Soc Biomaterials Japanese Soc Biomaterials Australian Soc Biomaterials Korean Soc Biomaterials. 2001;58(4):449–55.

Article  CAS 

Comments (0)

No login
gif