LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis

Alsina M, Arrazubi V, Diez M, Tabernero J (2022) Current developments in gastric cancer: from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol 20:155–170

Article  PubMed  Google Scholar 

Bin YL, Hu HS, Tian F, Wen ZH, Yang MF, Wu BH, Wang LS, Yao J, Li DF (2021) Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect. Front Oncol 11:745209

Article  PubMed  CAS  Google Scholar 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424

Article  PubMed  Google Scholar 

Chen L, Chen W, Zhao C, Jiang Q (2021) LINC01224 Promotes Colorectal Cancer Progression by Sponging miR-2467. Cancer Manag Res 13:733–742

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen M, Lu J, Wei W, Lv Y, Zhang X, Yao Y, Wang L, Ling T, Zou X (2018) Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo. Onco Targets Ther 11:6705–6722

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Y, Wang X (2020) miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res 48:D127-d131

Article  PubMed  CAS  Google Scholar 

Cheng J, Zhuo H, Wang L, Zheng W, Chen X, Hou J, Zhao J, Cai J (2020) Identification of the combinatorial effect of miRNA family regulatory network in different growth patterns of GC. Mol Ther Oncolytics 17:531–546

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng J, Zhuo H, Xu M, Wang L, Xu H, Peng J, Hou J, Lin L, Cai J (2018) Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med 16:216

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dai ZT, Xiang Y, Zhang XY, Zong QB, Wu QF, Huang Y, Shen C, Li JP, Ponnambalam S, Liao XH (2021) Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression. Aging (Albany NY) 13:20302–20318

Article  PubMed  CAS  Google Scholar 

Deng P, Li K, Gu F, Zhang T, Zhao W, Sun M, Hou B (2021) LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis. Mol Med 27:9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Cote G, Martin-Jimenez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940

Article  PubMed  PubMed Central  CAS  Google Scholar 

Feng Q, Wu X, Li F, Ning B, Lu X, Zhang Y, Pan Y, Guan W (2017) miR-27b inhibits gastric cancer metastasis by targeting NR2F2. Protein Cell 8:114–122

Article  PubMed  CAS  Google Scholar 

Gong A, Luo X, Tan Y, Chen H, Luo G (2022) High expression of C10orf91 and LINC01224 in hepatocellular carcinoma and poor prognosis. Am J Transl Res 14:2567–2579

PubMed  PubMed Central  CAS  Google Scholar 

Gu J, Dong L, Wang Y, Nie W, Liu W, Zhao JA (2021) LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis. World J Surg Oncol 19:281

Article  PubMed  PubMed Central  Google Scholar 

Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15:509–524

Article  PubMed  CAS  Google Scholar 

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

Article  PubMed  CAS  Google Scholar 

Kaur P, Nagar S, Bhagwat M, Uddin M, Zhu Y, Vancurova I, Vancura A (2021) Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells. PLoS ONE 16:e0260400

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lei TX, He DJ, Cao J, Lv WG (2022) CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2. Eur J Med Res 27:135

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Z, Liu J, Que L, Tang X (2019) The immunoregulatory protein B7–H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway. J Cancer 10:5770–5784

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin XM, Wang ZJ, Lin YX, Chen H (2021) Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress. World J Surg Oncol 19:312

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Pan C, Guo L, Wu M, Guo J, Peng S, Wu Q, Zuo Q (2016) A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. J Hematol Oncol 9:76

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Cui Y, Ding N, Zhou C (2022) Knockdown of circ_0003928 ameliorates high glucose-induced dysfunction of human tubular epithelial cells through the miR-506-3p/HDAC4 pathway in diabetic nephropathy. Eur J Med Res 27:55

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Sun T, Piao C, Zhang Z, Kong C (2021) METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression. J Transl Med 19:209

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ma S, Fu X, Liu L, Liu Y, Feng H, Jiang H, Liu X, Liu R, Liang Z, Li M, Tian Z, Hu B, Bai Y, Liang B, Liu X (2021) Iron-dependent autophagic cell death induced by radiation in MDA-MB-231 breast cancer cells. Front Cell Dev Biol 9:723801

Article  PubMed  PubMed Central  Google Scholar 

Mao X, Zhou J, Kong L, Zhu L, Yang D, Zhang Z (2023) A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway. Biochem Biophys Res Commun 647:62–71

Article  PubMed  CAS  Google Scholar 

McGeary SE, Lin KS, Shi CY, Pham TM, Bisaria N, Kelley GM, Bartel DP (2019) The biochemical basis of microRNA targeting efficacy. Science 366:eaav1741

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mi Y, Li Q, Liu B, Wang D, Liu Z, Wang T, Wang Y, Zang Y, Zhou Y, Wen Y, Ding Y (2022) Ubiquitous mitochondrial creatine kinase promotes the progression of gastric cancer through a JNK-MAPK/JUN/HK2 axis regulated glycolysis. Gastric Cancer 26:69–81

Article  PubMed  PubMed Central  Google Scholar 

Mu X, Shen Z, Lin Y, Xiao J, Xia K, Xu C, Chen B, Shi R, Zhu A, Sun X, Tao T, Song X, Xuan Q (2022) LncRNA-MALAT1 regulates cancer glucose metabolism in prostate cancer via MYBL2/mTOR Axis. Oxid Med Cell Longev 2022:8693259

Article  PubMed  PubMed Central  Google Scholar 

Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS (2021) NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. Cell Metab 33:2380-2397.e9

Article  PubMed  PubMed Central 

Comments (0)

No login
gif