How does oxytocin modulate human behavior?

Gruber CW. Physiology of invertebrate oxytocin and vasopressin neuropeptides. Exp Physiol. 2014;99:55–61.

Article  PubMed  CAS  Google Scholar 

Carter CS. Oxytocin and human evolution. Curr Top Behav Neurosci. 2018;35:291–319.

Article  CAS  Google Scholar 

Shmygol A, Gullam J, Blanks A, Thornton S. Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. Acta Pharmacol Sin. 2006;27:827–32.

Article  PubMed  CAS  Google Scholar 

Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629–83.

Article  PubMed  CAS  Google Scholar 

Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol. 2004;25:150–76.

Article  PubMed  CAS  Google Scholar 

Kendrick KM. Oxytocin, motherhood and bonding. Exp Physiol. 2000;85:111S–124S.

Article  PubMed  CAS  Google Scholar 

Rogers Flattery CN, Coppeto DJ, Inoue K, Rilling JK, Preuss TM, Young LJ. Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species. Brain Struct Funct. 2022;227:1907–19.

Article  PubMed  CAS  Google Scholar 

Rokicki J, Kaufmann T, De Lange AMG, van der Meer D, Bahrami S, Sartorius AM, et al. Oxytocin receptor expression patterns in the human brain across development. Neuropsychopharmacology. 2022;47:1550–60.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jurek B, Neumann ID. The oxytocin receptor: from intracellular signaling to behavior. Physiol Rev. 2018;98:1805–908.

Article  PubMed  CAS  Google Scholar 

Froemke RC, Young LJ. Oxytocin, neural plasticity, and social behavior. Annu Rev Neurosci. 2021;44:359–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Menon R, Neumann ID. Detection, processing and reinforcement of social cues: regulation by the oxytocin system. Nat Rev Neurosci. 2023;24:761–77.

Article  PubMed  CAS  Google Scholar 

Melis MR, Argiolas A. Oxytocin, erectile function and sexual behavior: last discoveries and possible advances. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms221910376.

Article  PubMed  PubMed Central  Google Scholar 

Neumann ID, Slattery DA. Oxytocin in general anxiety and social fear: a translational approach. Biol Psychiatry. 2016;79:213–21.

Article  PubMed  CAS  Google Scholar 

Uvnäs-Moberg K, Handlin L, Petersson M. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Front Psychol. 2015. https://doi.org/10.3389/fpsyg.2014.01529.

Article  PubMed  PubMed Central  Google Scholar 

Veening JG, de Jong TR, Waldinger MD, Korte SM, Olivier B. The role of oxytocin in male and female reproductive behavior. Eur J Pharmacol. 2015;753:209–28.

Article  PubMed  CAS  Google Scholar 

Insel TR, Shapiro LE. Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proc Natl Acad Sci USA. 1992;89:5981–5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Olazábal DE, Sandberg NY. Variation in the density of oxytocin receptors in the brain as mechanism of adaptation to specific social and reproductive strategies. Gen Comp Endocrinol. 2020. https://doi.org/10.1016/j.ygcen.2019.113337.

Article  PubMed  Google Scholar 

Alves E, Fielder A, Ghabriel N, Sawyer M, Buisman-Pijlman FT. Early social environment affects the endogenous oxytocin system: a review and future directions. Front Endocrinol. 2015. https://doi.org/10.3389/fendo.2015.00032.

Article  Google Scholar 

Crockford C, Deschner T, Ziegler TE, Wittig RM. Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review. Front Behav Neurosci. 2014. https://doi.org/10.3389/fnbeh.2014.00068.

Article  PubMed  PubMed Central  Google Scholar 

King LB, Walum H, Inoue K, Eyrich NW, Young LJ. Variation in the oxytocin receptor gene predicts brain region-specific expression and social attachment. Biol Psychiatry. 2016;80:160–9.

Article  PubMed  CAS  Google Scholar 

Ross HE, Freeman SM, Spiegel LL, Ren X, Terwilliger EF, Young LJ. Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. J Neurosci. 2009;29:1312–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahern TH, Olsen S, Tudino R, Beery AK. Natural variation in the oxytocin receptor gene and rearing interact to influence reproductive and nonreproductive social behavior and receptor binding. Psychoneuroendocrinology. 2021. https://doi.org/10.1016/j.psyneuen.2021.105209.

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Zhao W, Kendrick KM. Affective touch in the context of development, oxytocin signaling, and autism. Front Psychol. 2022. https://doi.org/10.3389/fpsyg.2022.967791.

Article  PubMed  PubMed Central  Google Scholar 

Caldwell HK. Oxytocin and sex differences in behavior. Curr Opin Behav Sci. 2018;23:13–20.

Article  Google Scholar 

Insel TR. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron. 2010;65:768–79.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Paletta P, Bass N, Kavaliers M, Choleris E. The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators. Philos Trans R Soc Lond B Biol Sci. 2022. https://doi.org/10.1098/rstb.2021.0058.

Article  PubMed  PubMed Central  Google Scholar 

Burkett JP, Andari E, Johnson ZV, Curry DC, de Waal FB, Young LJ. Oxytocin-dependent consolation behavior in rodents. Science. 2016;351:375–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Burkhart JC, Gupta S, Borrego N, Heilbronner SR, Packer C. Oxytocin promotes social proximity and decreases vigilance in groups of African lions. iScience. 2022. https://doi.org/10.1016/j.isci.2022.104049.

Article  PubMed  PubMed Central  Google Scholar 

Razo RA, Velasco Vazquez ML, Turcanu P, Legrand M, Floch M, Weinstein TAR, et al. Long term effects of chronic intranasal oxytocin on adult pair bonding behavior and brain glucose uptake in titi monkeys (Plecturocebus cupreus). Horm Behav. 2022. https://doi.org/10.1016/j.yhbeh.2022.105126.

Article  PubMed  PubMed Central  Google Scholar 

Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T. Oxytocin promotes social bonding in dogs. Proc Natl Acad Sci USA. 2014;111:9085–90.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif