Effects of oxytocin administration on non-social executive functions in humans: a preregistered systematic review and meta-analysis

Jurek B, Neumann ID. The oxytocin receptor: from intracellular signaling to behavior. Physiol Rev. 2018;98:1805–908.

Article  PubMed  CAS  Google Scholar 

Schafer EA, Mackenzie K. The action of animal extracts on milk secretion. Proc R Soc Lond B. 1911;84:16–22.

Article  CAS  Google Scholar 

Ott I, Scott JC. The galactagogue action of the thymus and corpus luteum. Exp Biol Med. 1910;8:49–49.

Article  Google Scholar 

Dale HH. On some physiological actions of ergot. J Physiol. 1906;34:163–206.

Article  PubMed  PubMed Central  Google Scholar 

Klopfer PH, Klopfer MS. Maternal “imprinting” in goats: fostering of alien young. Ethology. 1968;25:862–6.

Google Scholar 

Da Costa APC, Guevara-Guzman RG, Ohkura S, Goode JA, Kendrick KM. The role of oxytocin release in the paraventricular nucleus in the control of maternal behaviour in the sheep. J Neuroendocrinol. 1996;8:163–77.

Article  PubMed  Google Scholar 

Carter CS, Williams JR, Witt DM, Insel TR. Oxytocin and social bonding. Ann N Y Acad Sci. 1992;652:204–11.

Article  PubMed  CAS  Google Scholar 

Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature 2005;435:673–6.

Article  PubMed  CAS  Google Scholar 

Leng G, Leng RI, Ludwig M. Oxytocin—a social peptide? Deconstructing the evidence. Philos Trans R Soc B Biol Sci. 2022;377:20210055.

Article  Google Scholar 

Declerck CH, Boone C, Pauwels L, Vogt B, Fehr E. A registered replication study on oxytocin and trust. Nat Hum Behav. 2020;4:646–55.

Article  PubMed  Google Scholar 

Bradley ER, Woolley JD. Oxytocin effects in schizophrenia: reconciling mixed findings and moving forward. Neurosci Biobehav Rev. 2017;80:36–56.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alvares GA, Quintana DS, Whitehouse AJ. Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder. Autism Res. 2017;10:25–41.

Article  PubMed  Google Scholar 

Zak PJ, Stanton AA, Ahmadi S. Oxytocin increases generosity in humans. PLoS ONE. 2007;2:e1128.

Article  PubMed  PubMed Central  Google Scholar 

Lane A, Mikolajczak M, Treinen E, Samson D, Corneille O, de Timary P, et al. Failed replication of oxytocin effects on trust: the envelope task case. PloS ONE. 2015;10:e0137000.

Article  PubMed  PubMed Central  Google Scholar 

Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y. Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biol Psychiatry. 2009;66:864–70.

Article  PubMed  CAS  Google Scholar 

Shamay-Tsoory SG, Abu-Akel A. The social salience hypothesis of oxytocin. Biol Psychiatry. 2016;79:194–202.

Article  PubMed  CAS  Google Scholar 

Kemp AH, Guastella AJ. The role of oxytocin in human affect a novel hypothesis. Curr Dir Psychol Sci. 2011;20:222–31.

Article  Google Scholar 

Wirth MM. Hormones, stress, and cognition: the effects of glucocorticoids and oxytocin on memory. Adapt Hum Behav Physiol. 2015;1:177–201.

Article  Google Scholar 

Quintana DS, Guastella AJ. An allostatic theory of oxytocin. Trends Cogn Sci. 2020;24:515–28.

Article  PubMed  Google Scholar 

Chini B, Leonzino M, Braida D, Sala M. Learning about oxytocin: pharmacologic and behavioral issues. Biol Psychiatry. 2014;76:360–6.

Article  PubMed  CAS  Google Scholar 

Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V. et al. Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biol Psychiatry. 2011;69:875–82.

Article  PubMed  CAS  Google Scholar 

Theodosis DT, Koksma J-J, Trailin A, Langle SL, Piet R, Lodder JC, et al. Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. Mol Cell Neurosci. 2006;31:785–94.

Article  PubMed  CAS  Google Scholar 

Roberts BZ, Young JW, He YV, Cope ZA, Shilling PD, Feifel D. Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats. Neuropharmacology. 2019;150:15–26.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tapp DN, Singstock MD, Gottliebson MS, McMurray MS. Central but not peripheral oxytocin administration reduces risk-based decision-making in male rats. Horm Behav. 2020;125:104840.

Article  PubMed  CAS  Google Scholar 

Russell J, Maguire S, Hunt GE, Kesby A, Suraev A, Stuart J, et al. Intranasal oxytocin in the treatment of anorexia nervosa: Randomized controlled trial during re-feeding. Psychoneuroendocrinology. 2018;87:83–92.

Article  PubMed  CAS  Google Scholar 

Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, et al. Oxytocin Infusion reduces repetitive behaviors in adults with autistic and asperger’s disorders. Neuropsychopharmacology. 2003;28:193–8.

Article  PubMed  CAS  Google Scholar 

Feifel D, MacDonald K, Cobb P, Minassian A. Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophr Res. 2012;139:207–10.

Article  PubMed  Google Scholar 

Michalopoulou PG, Averbeck BB, Kalpakidou AK, Evans S, Bobin T, Kapur S, et al. The effects of a single dose of oxytocin on working memory in schizophrenia. Schizophr Res. 2015;162:62–63.

Article  PubMed  PubMed Central  Google Scholar 

Flanagan JC, Hand A, Jarnecke AM, Moran-Santa Maria MM, Brady KT, Joseph JE. Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder. Exp Clin Psychopharmacol. 2018;26:391–402.

Article  PubMed  PubMed Central  Google Scholar 

Fisher ER, Rocha NP, Morales-Scheihing DA, Venna VR, Furr-Stimming EE, Teixeira AL, et al. The relationship between plasma oxytocin and executive functioning in Huntington’s disease: a pilot study. J Huntingt’s Dis. 2021;10:349–54.

Article  CAS  Google Scholar 

Kapetaniou GE, Reinhard MA, Christian P, Jobst A, Tobler PN, Padberg F, et al. The role of oxytocin in delay of gratification and flexibility in non-social decision making. eLife. 2021;10:e61844.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gross J, De Dreu CKW. Oxytocin conditions trait-based rule adherence. Soc Cogn Affect Neurosci. 2017;12:427–35.

Article  PubMed  Google Scholar 

De Dreu CKW, Baas M, Boot N. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research. Wiley Interdiscip Rev Cogn Sci. 2015;6:409–17.

Article  PubMed  Google Scholar 

Quintana DS, Lischke A, Grace S, Scheele D, Ma Y, Becker B. Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research. Mol Psychiatry. 2021;26:80–91.

Article  PubMed  CAS 

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