First-in-human Evaluation of Safety and Dosimetry of [64Cu]FBP8: A fibrin-binding PET Probe

Davenport MS, Perazella MA, Yee J et al (2020) Use of Intravenous Iodinated contrast media in patients with kidney disease: Consensus statements from the American College of Radiology and the National Kidney Foundation. Radiology 294:660–668

Article  PubMed  Google Scholar 

Perelli F, Turrini I, Giorgi MG et al (2022) Contrast agents during pregnancy: pros and cons when really needed. Int J Environ Res Public Health 19:16699–16699

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kersey CB, Lele AV, Johnson MN et al (2023) The quality and safety of sedation and monitoring in adults undergoing nonoperative Transesophageal Echocardiography. Am J Cardiol 194:40–45

Article  PubMed  PubMed Central  Google Scholar 

Zierler BK (2004) Ultrasonography and diagnosis of venous thromboembolism. Circulation 109:9–14

Article  Google Scholar 

Thackeray JT, Diekmann J (2022) Fibrin-targeted PET/CMR in Atrial Fibrillation. JACC Cardiovasc Imaging 15:516–518

Article  PubMed  Google Scholar 

Mendiola AS, Yan Z, Dixit K et al (2023) Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol 24:1173–1187

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen T, Zhang Z (2023) Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases. Front Neurosci 17:1–13

Article  Google Scholar 

Kwaan HC, Lindholm PF (2019) Fibrin and fibrinolysis in Cancer. Semin Thromb Hemost 45:413–422

Article  CAS  PubMed  Google Scholar 

Whyte CS, Morrow GB, Mitchell JL, Chowdary P, Mutch NJ (2020) Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. J Thromb Haemost 18:1548–1555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shea BS, Probst CK, Brazee PL et al (2017) Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis. JCI Insight 2

Proal AD, VanElzakker MB, Aleman S et al (2023) SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nat Immunol 24:1616–1627

Article  CAS  PubMed  Google Scholar 

Kolodziej AF, Nair SA, Graham P et al (2012) Fibrin specific peptides derived by Phage Display: characterization of peptides and conjugates for imaging. Bioconjug Chem 23:548–556

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciesienski KL, Yang Y, Ay I et al (2013) Fibrin-targeted PET probes for the detection of thrombi. Mol Pharm 10:1100–1110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boros E, Rybak-Akimova E, Holland JP et al (2014) Pycup—A Bifunctional, cage-like Ligand for 64 Cu Radiolabeling. Mol Pharm 11:617–629

Article  CAS  PubMed  Google Scholar 

Ay I, Blasi F, Rietz TA et al (2014) In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe. Circ Cardiovasc Imaging 7:697–705

Article  PubMed  PubMed Central  Google Scholar 

Oliveira BL, Blasi F, Rietz TA, Rotile NJ, Day H, Caravan P (2015) Multimodal Molecular Imaging reveals high Target Uptake and specificity of 111 In- and 68 Ga-Labeled fibrin-binding probes for Thrombus detection in rats. J Nucl Med 56:1587–1592

Article  CAS  PubMed  Google Scholar 

Blasi F, Oliveira BL, Rietz TA et al (2014) Effect of Chelate Type and Radioisotope on the imaging efficacy of 4 fibrin-specific PET probes. J Nucl Med 55:1157–1163

Article  CAS  PubMed  Google Scholar 

Blasi F, Oliveira BL, Rietz Ta et al (2015) Radiation dosimetry of the fibrin-binding probe 64Cu-FBP8 and its feasibility for positron emission tomography imaging of deep vein thrombosis and pulmonary embolism in rats. J Nucl Med 56:1088–1093

Article  CAS  PubMed  Google Scholar 

Blasi F, Oliveira BL, Rietz TA et al (2015) Multisite Thrombus imaging and fibrin content estimation with a single whole-body PET scan in rats. Arterioscler Thromb Vasc Biol 35:2114–2121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Izquierdo-Garcia D, Désogère P, Philip AL et al (2022) Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance. JACC Cardiovasc Imaging

Book  Google Scholar 

Munchel JK, Misra AK, Collins SA et al (2024) Fibrin-PET Imaging Reveals Ongoing Lung Injury in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med

Google Scholar 

Shidahara M, Tashiro M, Okamura N et al (2013) Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans. EJNMMI Res 3:32–32

Article  PubMed  PubMed Central  Google Scholar 

Martinez-Moller A, Souvatzoglou M, Delso G et al (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50:520–526

Article  PubMed  Google Scholar 

Stabin MG, Siegel JA (2018) RADAR dose estimate report: a compendium of radiopharmaceutical dose estimates based on OLINDA/EXM version 2.0. J Nucl Med 59:154–160

Article  PubMed  Google Scholar 

Pfeifer A, Knigge U, Mortensen J et al (2012) Clinical PET of neuroendocrine tumors using 64Cu-DOTATATE: first-in-humans study. J Nucl Med 53:1207–1215

Article  CAS  PubMed  Google Scholar 

Laforest R, Dehdashti F, Lewis JS, Schwarz SW (2005) Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PET. Eur J Nucl Med Mol Imaging 32:764–770

Article  CAS  PubMed  Google Scholar 

Laforest R, Ghai A, Fraum TJ et al (2023) First-in-human evaluation of safety and dosimetry of 64 Cu-LLP2A for PET imaging. J Nucl Med 64(2):320–328

Sprague DR, Chin FT, Liow JS et al (2007) Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis. J Nucl Med 48:100–107

CAS  PubMed  Google Scholar 

Hindorf C, Glatting G, Chiesa C, Lindén O, Flux G (2010) EANM dosimetry committee guidelines for bone marrow and whole-body dosimetry. Eur J Nucl Med Mol Imaging 37:1238–1250

Article  PubMed  Google Scholar 

Avila-Rodriguez MA, Rios C, Carrasco-Hernandez J et al (2017) Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers. EJNMMI Res 7:98–98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Persson M, El Ali HH, Binderup T et al (2014) Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging. Nucl Med Biol 41:290–295

Article  CAS  PubMed  Google Scholar 

López-Rodríguez V, Galindo-Sarco C, García-Pérez FO, Ferro-Flores G, Arrieta O, Ávila-Rodríguez MA (2016) PET-based human dosimetry of the dimeric α v β 3 integrin ligand 68 Ga-DOTA-E-[c(RGDfK)] 2, a potential tracer for imaging tumor angiogenesis. J Nucl Med 57:404–409

Article  PubMed  Google Scholar 

Izquierdo-Garcia D, Désogère P, Fur ML et al (2023) Biodistribution, Dosimetry, and pharmacokinetics of 68 Ga-CBP8: A type I collagen–targeted PET probe. J Nucl Med 64:775–781

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quinn B, Dauer Z, Pandit-Taskar N, Schoder H, Dauer LT (2016) Radiation dosimetry of 18F-FDG PET/CT: incorporating exam-specific parameters in dose estimates. BMC Med Imaging 16:41–41

Article  PubMed  PubMed Central 

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