The mediating role of life course cognitive reserve-enhancing factors in the relationship between adverse childhood experiences and dementia among older adults: evidence from a prospective cohort study in the United States

Frankish H, Horton R (2017) Prevention and management of dementia: a priority for public health. Lancet 390(10113):2614–2615. https://doi.org/10.1016/s0140-6736(17)31756-7

Article  PubMed  Google Scholar 

GBD 2019 Diseases and Injuries Collaborators (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet 396(10258):1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9

Article  Google Scholar 

Livingston G, Huntley J, Liu KY, Costafreda SG, Selbæk G, Alladi S, Ames D, Banerjee S, Burns A, Brayne C, Fox NC, Ferri CP, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Nakasujja N, Rockwood K, Samus Q, Shirai K, Singh-Manoux A, Schneider LS, Walsh S, Yao Y, Sommerlad A, Mukadam N (2024) Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet 404(10452):572–628. https://doi.org/10.1016/s0140-6736(24)01296-0

Article  PubMed  Google Scholar 

Hughes K, Bellis MA, Hardcastle KA, Sethi D, Butchart A, Mikton C, Jones L, Dunne MP (2017) The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Health 2(8):e356–e366. https://doi.org/10.1016/s2468-2667(17)30118-4

Article  PubMed  Google Scholar 

Bick J, Nelson CA (2016) Early adverse experiences and the developing brain. Neuropsychopharmacology 41(1):177–196. https://doi.org/10.1038/npp.2015.252

Article  CAS  PubMed  Google Scholar 

Lin L, Cao B, Chen W, Li J, Zhang Y, Guo VY (2022) Association of Adverse Childhood Experiences and social isolation with later-life cognitive function among adults in China. JAMA Netw Open 5(11):e2241714. https://doi.org/10.1001/jamanetworkopen.2022.41714

Article  PubMed  PubMed Central  Google Scholar 

Lowry E, McInerney A, Schmitz N, Deschênes SS (2022) Adverse childhood experiences and cognitive function in adulthood: examining the roles of depressive symptoms and inflammation in a prospective cohort study. Soc Psychiatry Psychiatr Epidemiol 57(12):2367–2377. https://doi.org/10.1007/s00127-022-02315-w

Article  PubMed  PubMed Central  Google Scholar 

Brown MJ, Kaur A, James T, Avalos C, Addo PNO, Crouch E, Hill NL (2022) Adverse childhood experiences and Subjective Cognitive decline in the US. J Appl Gerontol 41(4):1090–1100. https://doi.org/10.1177/07334648211058718

Article  PubMed  Google Scholar 

Corney KB, West EC, Quirk SE, Pasco JA, Stuart AL, Manavi BA, Kavanagh BE, Williams LJ (2022) The relationship between adverse childhood experiences and Alzheimer’s Disease: a systematic review. Front Aging Neurosci 14:831378. https://doi.org/10.3389/fnagi.2022.831378

Article  PubMed  PubMed Central  Google Scholar 

Huang Z, Jordan JD, Zhang Q (2023) Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease. Transl Neurodegener 12(1):25. https://doi.org/10.1186/s40035-023-00355-z

Article  PubMed  PubMed Central  Google Scholar 

Wilhoite SR, Zaheed AB, Palms JD, Morris EP, Sol K, Martino A, Zahodne LB (2023) Mechanisms underlying the association between adverse childhood experiences and racial disparities in later-life cognition. J Int Neuropsychol Soc 1–11. https://doi.org/10.1017/S1355617723000474

Ma J, Yang Y, Wan Y, Shen C, Qiu P (2021) The influence of childhood adversities on mid to late cognitive function: from the perspective of life course. PLoS ONE 16(8):e0256297. https://doi.org/10.1371/journal.pone.0256297

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whalley LJ, Staff RT, Murray AD, Deary IJ, Starr JM (2013) Genetic and environmental factors in late onset dementia: possible role for early parental death. Int J Geriatr Psychiatry 28(1):75–81. https://doi.org/10.1002/gps.3792

Article  PubMed  Google Scholar 

Stern Y (2009) Cognitive reserve. Neuropsychologia 47(10):2015–2028. https://doi.org/10.1016/j.neuropsychologia.2009.03.004

Article  PubMed  PubMed Central  Google Scholar 

Elder GH Jr (1998) The Life Course as Developmental Theory. Child Dev 69(1):1–12. https://doi.org/10.1111/j.1467-8624.1998.tb06128.x

Article  PubMed  Google Scholar 

Wang HX, MacDonald SW, Dekhtyar S, Fratiglioni L (2017) Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: a community-based cohort study. PLoS Med 14(3):e1002251. https://doi.org/10.1371/journal.pmed.1002251

Article  PubMed  PubMed Central  Google Scholar 

Whalley LJ, Dick FD, McNeill G (2006) A life-course approach to the aetiology of late-onset dementias. Lancet Neurol 5(1):87–96. https://doi.org/10.1016/s1474-4422(05)70286-6

Article  PubMed  Google Scholar 

Yang L, Wang Z (2020) Early-life conditions and cognitive function in Middle-and old-aged Chinese adults: a longitudinal study. Int J Environ Res Public Health 17(10):3451. https://doi.org/10.3390/ijerph17103451

Article  PubMed  PubMed Central  Google Scholar 

Peng C, Burr JA, Yang D, Lu N (2021) Early child–parent relationship quality and cognitive function in older rural Chinese adults: the mediating role of Educational Attainment. J Aging Health 33(7–8):493–503. https://doi.org/10.1177/0898264321996562

Article  PubMed  Google Scholar 

Bondi MW, Edmonds EC, Salmon DP (2017) Alzheimer’s disease: past, present, and future. J Int Neuropsychol Soc 23(9–10):818–831. https://doi.org/10.1017/S135561771700100X

Article  PubMed  PubMed Central  Google Scholar 

Davies G, Harris SE, Reynolds CA, Payton A, Knight HM, Liewald DC, Lopez LM, Luciano M, Gow AJ, Corley J, Henderson R, Murray C, Pattie A, Fox HC, Redmond P, Lutz MW, Chiba-Falek O, Linnertz C, Saith S, Haggarty P, McNeill G, Ke X, Ollier W, Horan M, Roses AD, Ponting CP, Porteous DJ, Tenesa A, Pickles A, Starr JM, Whalley LJ, Pedersen NL, Pendleton N, Visscher PM, Deary IJ (2014) A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol Psychiatry 19(1):76–87. https://doi.org/10.1038/mp.2012.159

Article  CAS  PubMed  Google Scholar 

Lambert J-C, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin C-F, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau M-T, Choi S-H, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MCD, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O’Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, De Bruijn RFAG, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JSK, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang L-S, Dartigues J-F, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, Van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet 45(12):1452–1458. https://doi.org/10.1038/ng.2802

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shannon OM, Ranson JM, Gregory S, Macpherson H, Milte C, Lentjes M, Mulligan A, McEvoy C, Griffiths A, Matu J, Hill TR, Adamson A, Siervo M, Minihane AM, Muniz-Tererra G, Ritchie C, Mathers JC, Llewellyn DJ, Stevenson E (2023) Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study. BMC Med 21(1):81. https://doi.org/10.1186/s12916-023-02772-3

Article  PubMed  PubMed Central  Google Scholar 

Peloso GM, Beiser AS, Satizabal CL, Xanthakis V, Vasan RS, Pase MP, Destefano AL, Seshadri S (2020) Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study. Neurology 95(10):e1341–e1350. https://doi.org/10.1212/WNL.0000000000010306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Littlejohns TJ, Collister JA, Liu X, Clifton L, Tapela NM, Hunter DJ (2023) Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia. Alzheimers Dement 19(2):467–476. https://doi.org/10.1002/alz.12680

Article  CAS  PubMed  Google Scholar 

Nelson CA, Scott RD, Bhutta ZA, Harris NB, Danese A, Samara M (2020) Adversity in childhood is linked to mental and physical health throughout life. BMJ 371:m3048. https://doi.org/10.1136/bmj.m3048

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