Addington J, Heinssen R (2012) Prediction and prevention of psychosis in youth at clinical high risk. Annu Rev Clin Psychol 8:269–289

Article  PubMed  Google Scholar 

Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzmán M, Galve-Roperh I (2005) The endocannabinoid system drives neural progenitor proliferation. FASEB J 19:1704–1706

Article  CAS  PubMed  Google Scholar 

Beggiato S, Ieraci A, Zuccarini M, Di, Iorio P, Schwarcz R, Ferraro L (2022) Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence. Front Psychiatry 13:996406

Article  PubMed  PubMed Central  Google Scholar 

Berding G, Schneider U, Gielow P, Buchert R, Donnerstag F, Brandau W, Knapp WH, Emrich HM, Muller-Vahl K (2006) Feasibility of central cannabinoid CB1 receptor imaging with [124I]AM281 PET demonstrated in a schizophrenic patient. Psychiatry Res 147:249–256

Article  CAS  PubMed  Google Scholar 

Białoń M, Wąsik A (2022) Advantages and limitations of animal Schizophrenia models. Int J Mol Sci 23:5968

Article  PubMed  PubMed Central  Google Scholar 

Booth WT, Walker NB, Lowther WT, Howlett AC (2019) Cannabinoid Receptor Interacting Protein 1a (CRIP1a): function and structure. Molecules 24:3672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H (1992) Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology 109:489–496

Article  CAS  PubMed  Google Scholar 

Díaz-Alonso J, Guzmán M, I (2012) Galve-Roperh, endocannabinoids via CB1 receptorsact as neurogenic niche cues during cortical development. Philos Trans R Soc Lond Ser B Biol Sci 367:3229–3241

Article  Google Scholar 

Donegan JJ, Tyson JA, Branch SY, Beckstead MJ, Anderson SA, Lodge DJ (2017) Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Mol Psychiatry 22:1492–1501

Article  CAS  PubMed  Google Scholar 

Fernandez-Espejo E, Viveros MP, Nunez L, Ellenbroek BA, de Rodriguez F (2009) Role of cannabis and endocannabinoids in the genesis of schizophrenia. Psychopharmacology 206:531–549

Article  CAS  PubMed  Google Scholar 

Flagstad P, Mork A, Glenthoj BY, van Beek J, Michael-Titus AT, Didriksen M (2004) Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology 29:2052–2064

Article  CAS  PubMed  Google Scholar 

García-Gutiérrez MS, Navarrete F, Gasparyan A, Austrich-Olivares A, Sala F, Manzanares J (2020) Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders. Biomolecules 10:1575

Geyer MA, Swerdlow NR, Mansbach RS, Braff DL (1990) Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 25:485–498

Article  CAS  PubMed  Google Scholar 

Goulding SM, Holtzman CW, Trotman HD, Ryan AT, Macdonald AN, Shapiro DI, Brasfield JL, Walker EF (2013) The prodrome and clinical risk for psychotic disorders. Child Adolesc Psychiatr Clin N Am 22:557–567

Article  PubMed  PubMed Central  Google Scholar 

Grace AA (2017) Dopamine system dysregulation and the pathophysiology of schizophrenia: insights from the methylazoxymethanol acetate model. Biol Psychiatry 81:5–8

Article  CAS  PubMed  Google Scholar 

Hoareau C, Hazane F, Le Pen G, Krebs MO (2006) Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus. Brain Res 1097:43–51

Article  CAS  PubMed  Google Scholar 

Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54(2):161–202

Article  CAS  PubMed  Google Scholar 

Hwang IK, Yoo KY, Kim DH, Lee BU, Kwon YG, Won MH (2007) Time course of changes in pyridoxal 5’-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Exp Neurol 206:114–125

Article  CAS  PubMed  Google Scholar 

Jeanclos E, Albersen M, Ramos RJJ, Raab A, Wilhelm C, Hommers L, Lesch KP, Verhoeven-Duif NM, Gohla A (2019) Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice. Biochim Biophys Acta Mol Basis Dis 1865:193–205

Article  CAS  PubMed  Google Scholar 

Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC, Squire LR, Gage FH (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 16:147–154

Article  PubMed  PubMed Central  Google Scholar 

Jung HY, Kim DW, Nam SM, Kim JW, Chung JY, Won MH, Seong JK, Yoon YS, Yoo DY, Hwang IK (2017) Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway. Biochim Biophys Acta Gen Subj 1861:3142–3153

Article  CAS  PubMed  Google Scholar 

Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, O’Donovan M, Correll CU, Kane JM, van Os J, Insel TR (2015) Schizophrenia. Nat Rev Dis Primers 1:15067

Article  PubMed  Google Scholar 

Kállai V, Tóth A, Gálosi R, Szabó I, Petykó Z, Karádi Z, Kállai J, Lénárd L (2015) MAM-E17 schizophrenia rat model. Psychiatr Hung 30:4–17

PubMed  Google Scholar 

Keshavan MS, Giedd J, Lau JY, Lewis DA, Paus T (2014) Changes in the adolescent brain and the pathophysiology of psychotic disorders. Lancet Psychiatry 1:549–558

Article  PubMed  Google Scholar 

Khodamoradi M, Tirgar F, Ghazvini H, Rafaiee R, Tamijani SMS, Karimi N, Yadegari A, Khachaki AS, Akhtari J (2022) Role of the cannabinoid CB1 receptor in methamphetamine-induced social and recognition memory impairment. Neurosci Lett 779:136634

Article  CAS  PubMed  Google Scholar 

Krishna AP, Ramakrishna T (2004) Effect of pyridoxine deficiency on the structural and functional development of hippocampus. Indian J Physiol Pharmacol 48:304–310

CAS  PubMed  Google Scholar 

Kuypers NJ, Hoane MR (2010) Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat. J Neurotrauma 27:1275–1282

Article  PubMed  PubMed Central  Google Scholar 

Lesh TA, Niendam TA, Minzenberg MJ, Carter CS (2011) Cognitive control deficits in schizophrenia: mechanisms and meaning. Neuropsychopharmacology 36:316–338

Article  PubMed  Google Scholar 

Li XH, Xue C, Liu MQ, Zhang MY, Zhou Y, Xiao X, Wang J, Xu XJ, Shi Y, Zhang WN (2021) Attractin gene lack in rats leads to the deficiency in both activity and spatial learning and memory. Neuroscience 466:101–108

Article  CAS  PubMed  Google Scholar 

Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK (2005) Clinical antipsychotic trials of intervention effectiveness, I. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353:1209-1223

Malone DT, Taylor DA (2006) The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behav Brain Res 166:101–109

Article  CAS  PubMed  Google Scholar 

Meyer U, Feldon J (2010) Epidemiology-driven neurodevelopmental animal models of schizophrenia. Prog Neurobiol 90:285–326

Article  PubMed  Google Scholar 

Meyer-Lindenberg A (2010) From maps to mechanisms through neuroimaging of schizophrenia. Nature 468:194–202

Article  CAS  PubMed  Google Scholar