Kohli RM, Zhang Y (2013) TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502(7472):472–479

Article  PubMed  PubMed Central  CAS  Google Scholar 

Roundtree IA, Evans ME, Pan T, He C (2017) Dynamic RNA modifications in gene expression regulation. Cell 169(7):1187–1200

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akçaöz A, Akgül B (2022) Epitranscriptomics changes the play: m(6)A RNA modifications in apoptosis. Adv Exp Med Biol 1401:163–171

Article  PubMed  Google Scholar 

Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147(4):742–758

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D’Orazi G (2016) Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany NY) 8(4):603–619

Article  PubMed  CAS  Google Scholar 

Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495–516

Article  PubMed  PubMed Central  CAS  Google Scholar 

Norbury CJ, Hickson ID (2001) Cellular responses to DNA damage. Annu Rev Pharmacol Toxicol 41:367–401

Article  PubMed  CAS  Google Scholar 

Häcker G (2000) The morphology of apoptosis. Cell Tissue Res 301(1):5–17

Article  PubMed  Google Scholar 

Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45(3):528–537

Article  PubMed  CAS  Google Scholar 

Hengartner MO (2001) Apoptosis: corralling the corpses. Cell 104(3):325–328

Article  PubMed  CAS  Google Scholar 

Li J, Yuan J (2008) Caspases in apoptosis and beyond. Oncogene 27(48):6194–6206

Article  PubMed  CAS  Google Scholar 

Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281(5381):1312–1316

Article  PubMed  CAS  Google Scholar 

Nicholson DW (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6(11):1028–1042

Article  PubMed  CAS  Google Scholar 

Guicciardi ME, Gores GJ (2009) Life and death by death receptors. Faseb j 23(6):1625–1637

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu X, Lai Y, Hua ZC (2019) Apoptosis and apoptotic body: disease message and therapeutic target potentials. Biosci Rep 39(1):BSR20180992. https://doi.org/10.1042/BSR20180992

Article  PubMed  PubMed Central  CAS  Google Scholar 

Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273(5):2926–2930

Article  PubMed  CAS  Google Scholar 

Liu S, Zhuo L, Wang J, Zhang Q, Li Q, Li G, Yan L, Jin T et al (2020a) METTL3 plays multiple functions in biological processes. Am J Cancer Res 10(6):1631–1646

PubMed  PubMed Central  CAS  Google Scholar 

Pan G, O’Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (1997) The receptor for the cytotoxic ligand TRAIL. Science 276(5309):111–113

Article  PubMed  CAS  Google Scholar 

Zaman S, Wang R, Gandhi V (2014) Targeting the apoptosis pathway in hematologic malignancies. Leuk Lymphoma 55(9):1980–1992

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lomonosova E, Chinnadurai G (2008) BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27(Suppl 1(Suppl 1)):S2–S19

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lopez J, Tait SW (2015) Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer 112(6):957–962

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N (2014) Apoptosis and molecular targeting therapy in cancer. Biomed Res Int 2014:150845

Article  PubMed  PubMed Central  Google Scholar 

Laboratory, Cold Spring Harbor (1943) Cold Spring Harbor perspectives in biology. Cold Spring Harbor Laboratory Press

Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305(5684):626–629

Article  PubMed  CAS  Google Scholar 

Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87(1):99–163

Article  PubMed  CAS  Google Scholar 

Luo X, Budihardjo I, Zou H, Slaughter C, Wang X (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94(4):481–490

Article  PubMed  CAS  Google Scholar 

Vairo G, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, Adams JM (2000) Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation. Mol Cell Biol 20(13):4745–4753

Article  PubMed  PubMed Central  CAS  Google Scholar 

Greider C, Chattopadhyay A, Parkhurst C, Yang E (2002) BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases. Oncogene 21(51):7765–7775

Article  PubMed  CAS  Google Scholar 

Huang DC, O’Reilly LA, Strasser A, Cory S (1997) The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. Embo j 16(15):4628–4638

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fujise K, Zhang D, Liu J, Yeh ET (2000) Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen. J Biol Chem 275(50):39458–39465

Article  PubMed  CAS  Google Scholar 

Harley ME, Allan LA, Sanderson HS, Clarke PR (2010) Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. Embo j 29(14):2407–2420

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jamil S, Stoica C, Hackett TL, Duronio V (2010) MCL-1 localizes to sites of DNA damage and regulates DNA damage response. Cell Cycle 9(14):2843–2855

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pawlikowska P, Leray I, de Laval B, Guihard S, Kumar R, Rosselli F, Porteu F (2010) ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response. Cell Death Differ 17(11):1739–1750

Article  PubMed  CAS  Google Scholar 

Clarke PR, Allan LA, Skowyra A (2018) Timed degradation of Mcl-1 controls mitotic cell death. Mol Cell Oncol 5(6):e1516450

Article  PubMed  PubMed Central  Google Scholar 

Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15(22):2922–2933

PubMed  CAS  Google Scholar 

Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR et al (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292(5517):727–730

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW (2008) Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135(6):1074–1084

Article  PubMed  CAS  Google Scholar 

Let