Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond). 2012;122:143–59.
Article CAS PubMed Google Scholar
Kaur S, Bansal Y, Kumar R, Bansal G. A panoramic review of IL-6: structure, pathophysiological roles and inhibitors. Bioorg Med Chem. 2020;28(5):115327.
Article CAS PubMed Google Scholar
Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15:234–48.
Article CAS PubMed Google Scholar
Kollmann Z, Schneider S, Fux M, Bersinger NA, von Wolff M. Gonadotrophin stimulation in IVF alters the immune cell profile in follicular fluid and the cytokine concentrations in follicular fluid and serum. Hum Reprod. 2017;32:820–31.
Article CAS PubMed Google Scholar
Baskind NE, Orsi NM, Sharma V. Follicular-phase ovarian follicular fluid and plasma cytokine profiling of natural cycle in vitro fertilization patients. Fertil Steril. 2014;102(2):410–8.
Article CAS PubMed Google Scholar
Jones ASK, Shikanov A. Follicle development as an orchestrated signaling network in a 3D organoid. J Biol Eng. 2019. https://doi.org/10.1186/s13036-018-0134-3.
Article PubMed PubMed Central Google Scholar
Wu R, Fujii S, Ryan NK, Van der Hoek KH, Jasper MJ, Sini I, Robertson SA, Robker RL, Norman RJ. Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome. Hum Reprod. 2007;22(2):527–35.
Article CAS PubMed Google Scholar
Field SL, Dasgupta T, Cummings M, Orsi NM. Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation. Mol Reprod. 2014;81(4):284–314.
Kawasaki F, Kawano Y, Kosay Hasan Z, Narahara H, Miyakawa I. The clinical role of interleukin-6 and interleukin-6 soluble receptor in human follicular fluids. Clin Exp Med. 2003;3:27–31.
Article CAS PubMed Google Scholar
Stojanovic Gavrilovic AZ, Cekovic JM, Parandilovic AZ, Nikolov AB, Sazdanovic PS, Velickovic AM, Andjelkovic MV, Sorak MP. IL-6 of follicular fluid and outcome of in vitro fertilization. Medicine. 2022. https://doi.org/10.1097/MD.0000000000029624.
Article PubMed PubMed Central Google Scholar
Yang J, Yang X, Yang H, Bai Y, Zha H, Jiang F, Meng Y. Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate. J Assist Reprod Genet. 2020;37(5):1171–6.
Article PubMed PubMed Central Google Scholar
Vilotić A, Nacka-Aleksić M, Pirković A, Bojić-Trbojević Ž, Dekanski D, Jovanović KM. IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies. Int J Mol Sci. 2022;23(23):14574.
Article PubMed PubMed Central Google Scholar
Mulayim N, Palter SF, Kayisli UA, Senturk L, Arici A. Chemokine receptor expression in human endometrium. Biol Reprod. 2003;68(5):1491–5.
Article CAS PubMed Google Scholar
Zhou M, Xu H, Zhang D, Si C, Zhou X, Zhao H, Liu Q, Xu B, Zhang A. Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization. J Adv Res. 2020;30:15–25.
Article PubMed PubMed Central Google Scholar
Thouas GA, Dominguez F, Green MP, Vilella F, Simon C, Gardner DK. Soluble ligands and their receptors in human embryo development and implantation. Endocr Rev. 2015;36:92–130.
Article CAS PubMed Google Scholar
Sharkey AM, Dellow K, Blayney M, Macnamee M, Charnock-Jones S, Smith SK. Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. Biol Reprod. 1995;53:974–81.
Article CAS PubMed Google Scholar
Yu C, Wang L, Li J, Guo C, Guo X, Zhang X, et al. Ovarian stimulation reduces IL-6 release from mouse and human pre-implantation embryos. Am J Reprod Immunol. 2012;68:199–204.
Article CAS PubMed Google Scholar
Austgulen R, Arntzen KJ, Vatten LJ, Kahn J, Sunde A. Detection of cytokines (interleukin-1, interleukin-6, transforming growth factor-beta) and soluble tumour necrosis factor receptors in embryo culture fluids during in-vitro fertilization. Hum Reprod. 1995;10:171–6.
Article CAS PubMed Google Scholar
Barañao RI, Piazza A, Rumi LS, Polak de Fried E. Determination of IL-1 and IL-6 levels in human embryo culture-conditioned media. Am J Reprod Immunol. 1997;37:191–4.
Cutting R, Morroll D, Roberts SA, Pickering S, Rutherford A, BFS and ACE. Elective single embryo transfer: guidelines for practice British Fertility Society and Association of Clinical Embryologists. Hum Fertil (Camb). 2008;11:131–46.
Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73:1155–8.
Article CAS PubMed Google Scholar
Zhong H, Sun Q, Chen P, Xiong F, Li G, Wan C, et al. Detection of IL-6, IL-10, and TNF-α level in human single-blastocyst conditioned medium using ultrasensitive Single Molecule Array platform and its relationship with embryo quality and implantation: a pilot study. J Assist Reprod Genet. 2020;37:1695–702.
Article PubMed PubMed Central Google Scholar
Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quiñonero A, Simón C. New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies. Fertil Steril. 2015;104:908–14.
Kelley RL, Gardner DK. Addition of interleukin-6 to mouse embryo culture increases blastocyst cell number and influences the inner cell mass to trophectoderm ratio. Clin Exp Reprod Med. 2017;44:119.
Article PubMed PubMed Central Google Scholar
Wooldridge LK, Ealy AD. Interleukin-6 increases inner cell mass numbers in bovine embryos. BMC Dev Biol. 2019. https://doi.org/10.1186/s12861-019-0182-z.
Article PubMed PubMed Central Google Scholar
Meng F, Forrester-Gauntlett B, Turner P, Henderson H, Oback B. Signal inhibition reveals JAK/STAT3 pathway as critical for bovine inner cell mass development. Biol Reprod. 2015. https://doi.org/10.1095/biolreprod.115.134254.
Wooldridge LK, Johnson SE, Cockrum RR, Ealy AD. Interleukin-6 requires JAK to stimulate inner cell mass expansion in bovine embryos. Reproduction. 2019;158:303–12.
Article CAS PubMed Google Scholar
Javvaji PK, Francis JR, Dhali A, Kolte AP, Mech A, Roy SC, Mishra A. Interleukin-6 stimulates in vitro development of late-stage ovine embryos. J Reprod Immunol. 2023. https://doi.org/10.1016/j.jri.2023.104133.
Plana-Carmona M, Stik G, Bulteau R, Segura-Morales C, Alcázar N, Wyatt CDR, Klonizakis A, de Andrés-Aguayo L, Gasnier M, Tian TV, Torcal Garcia G, Vila-Casadesús M, Plachta N, Serrano M, Francesconi M, Graf T. The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling. Stem Cell Reports. 2022;17(9):1991–2004.
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