Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Kilpatrick DG, Resnick HS, Milanak ME, Miller MW, Keyes KM, Friedman MJ. National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria. J Trauma Stress. 2013;26:537–47.

Article  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.

Etkin A, Wager TD. Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia. Am J Psychiatry. 2007;164:1476–88.

Article  PubMed  PubMed Central  Google Scholar 

Karl A, Schaefer M, Malta L, Dorfel D, Rohleder N, Werner A. A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev. 2006;30:1004–31.

Article  PubMed  Google Scholar 

O’Doherty DCM, Chitty KM, Saddiqui S, Bennett MR, Lagopoulos J. A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder. Psychiatry Res Neuroimaging. 2015;232:1–33.

Article  Google Scholar 

Corbo V, Salat DH, Amick MM, Leritz EC, Milberg WP, McGlinchey RE. Reduced cortical thickness in veterans exposed to early life trauma. Psychiatry Res Neuroimaging. 2014;223:53–60.

Article  Google Scholar 

Geuze E, Westenberg HGM, Heinecke A, de Kloet CS, Goebel R, Vermetten E. Thinner prefrontal cortex in veterans with posttraumatic stress disorder. Neuroimage. 2008;41:675–81.

Article  PubMed  Google Scholar 

Gold AL, Sheridan MA, Peverill M, Busso DS, Lambert HK, Alves S, et al. Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing. J Child Psychol Psychiatry. 2016;57:1154–64.

Article  PubMed  PubMed Central  Google Scholar 

Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, et al. SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans. Mol Psychiatry. 2016;21:357–63.

Article  CAS  PubMed  Google Scholar 

Sullivan DR, Morrison FG, Wolf EJ, Logue MW, Fortier CB, Salat DH, et al. The PPM1F gene moderates the association between PTSD and cortical thickness. J Affect Disord. 2019;259:201–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wrocklage KM, Averill LA, Cobb Scott J, Averill CL, Schweinsburg B, Trejo M, et al. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. Eur Neuropsychopharmacol. 2017;27:515–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bing X, Ming-guo Q, Ye Z, Jing-na Z, Min L, Han C, et al. Alterations in the cortical thickness and the amplitude of low-frequency fluctuation in patients with post-traumatic stress disorder. Brain Res. 2013;1490:225–32.

Article  CAS  PubMed  Google Scholar 

Crombie KM, Ross MC, Letkiewicz AM, Sartin-Tarm A, Cisler JM. Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD. Sci Rep. 2021;11:1825.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ross MC, Sartin-Tarm AS, Letkiewicz AM, Crombie KM, Cisler JM. Distinct cortical thickness correlates of early life trauma exposure and posttraumatic stress disorder are shared among adolescent and adult females with interpersonal violence exposure. Neuropsychopharmacology. 2021;46:741–9.

Article  PubMed  Google Scholar 

Lindemer ER, Salat DH, Leritz EC, McGlinchey RE, Milberg WP. Reduced cortical thickness with increased lifetime burden of PTSD in OEF/OIF Veterans and the impact of comorbid TBI. Neuroimage Clin. 2013;2:601–11.

Article  PubMed  PubMed Central  Google Scholar 

Clausen AN, Clarke E, Phillips RD, Haswell C, Morey RA. Combat exposure, posttraumatic stress disorder, and head injuries differentially relate to alterations in cortical thickness in military Veterans. Neuropsychopharmacology. 2020;45:491–8.

Article  PubMed  Google Scholar 

Woodward SH, Schaer M, Kaloupek DG, Cediel L, Eliez S. Smaller Global and Regional Cortical Volume in Combat-Related Posttraumatic Stress Disorder. Arch Gen Psychiatry. 2009;66:1373.

Article  PubMed  Google Scholar 

Dickie EW, Brunet A, Akerib V, Armony JL. Anterior cingulate cortical thickness is a stable predictor of recovery from post-traumatic stress disorder. Psychol Med. 2013;43:645–53.

Article  CAS  PubMed  Google Scholar 

Heyn SA, Herringa RJ. Longitudinal cortical markers of persistence and remission of pediatric PTSD. Neuroimage Clin. 2019;24:102028.

Article  PubMed  PubMed Central  Google Scholar 

Jeong H, Lee YJ, Kim N, Jeon S, Jun JY, Yoo SY, et al. Increased medial prefrontal cortical thickness and resilience to traumatic experiences in North Korean refugees. Sci Rep. 2021;11:14910.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lyoo IK, Kim JE, Yoon SJ, Hwang J, Bae S, Kim DJ. The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma. Arch Gen Psychiatry. 2011;68:701.

Article  PubMed  Google Scholar 

Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, et al. Combat exposure severity is associated with reduced cortical thickness in combat veterans: a preliminary report. Chronic Stress. 2017;1:1–9.

Clouston SAP, Deri Y, Horton M, Tang C, Diminich E, DeLorenzo C, et al. Reduced cortical thickness in World Trade Center responders with cognitive impairment. Alzheimer’s & Dementia: Diagnosis. Assess Dis Monit. 2020;12:e12059.

Google Scholar 

Demers LA, Olson EA, Crowley DJ, Rauch SL, Rosso IM. Dorsal Anterior Cingulate Thickness Is Related to Alexithymia in Childhood Trauma-Related PTSD. PLoS One. 2015;10:e0139807.

Article  PubMed  PubMed Central  Google Scholar 

Knight LK, Naaz F, Stoica T, Depue BE. Lifetime PTSD and geriatric depression symptomatology relate to altered dorsomedial frontal and amygdala morphometry. Psychiatry Res Neuroimaging. 2017;267:59–68.

Article  PubMed  Google Scholar 

Landré L, Destrieux C, Baudry M, Barantin L, Cottier J-P, Martineau J, et al. Preserved subcortical volumes and cortical thickness in women with sexual abuse-related PTSD. Psychiatry Res Neuroimaging. 2010;183:181–6.

Article  Google Scholar 

Rinne-Albers MA, Boateng CP, van der Werff SJ, Lamers-Winkelman F, Rombouts SA, Vermeiren RR, et al. Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse. Sci Rep. 2020;10:3266.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosada C, Bauer M, Golde S, Metz S, Roepke S, Otte C, et al. Childhood trauma and cortical thickness in healthy women, women with post-traumatic stress disorder, and women with borderline personality disorder. Psychoneuroendocrinology. 2023;153:106118.

Article  PubMed  Google Scholar 

Sun D, Haswell CC, Morey RA, De Bellis MD. Brain structural covariance network centrality in maltreated youth with PTSD and in maltreated youth resilient to PTSD. Dev Psychopathol. 2019;31:557–71.

Article  CAS  PubMed  Google Scholar 

Li S, Huang X, Li L, Du F, Li J, Bi F, et al. Posttraumatic Stress Disorder: Structural Characterization with 3-T MR Imaging. Radiology. 2016;280:537–44.

Article  PubMed  Google Scholar 

Qi S, Mu Y, Liu K, Zhang J, Huan Y, Tan Q, et al. Cortical inhibition deficits in recent onset PTSD after a single prolonged trauma exposure. Neuroimage Clin. 2013;3:226–33.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Zhang Y, Zhao Y, Li Z, Kemp GJ, Wu M, et al. Cortical thickness abnormalities in patients with post-traumatic stress disorder: A vertex-based meta-analysis. Neurosci Biobehav Rev. 2022;134:104519.

Article  PubMed  Google Scholar 

Galatzer-Levy IR, Bryant RA. 636,120 Ways to Have Posttraumatic Stress Disorder. Perspect Psychol Sci. 2013;8:651–62.

Article  PubMed  Google Scholar 

Sotiras A, Resnick SM, Davatzikos C. Finding imaging patterns of structural covariance via Non-Negative Matrix Factorization. Neuroimage. 2015;108:1–16.

Article  PubMed  Google Scholar 

Sotiras A, Toledo JB, Gur RE, Gur RC, Satterthwaite TD, Davatzikos C. Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion. Proc Natl Acad Sci. 2017;114:3527–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui Z, Li H, Xia CH, Larsen B, Adebimpe A, Baum GL, et al. Individual Variation in Functional Topography of Association Networks in Youth. Neuron. 2020;106:340–53.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun D, Adduru VR, Phillips RD, Bouchard HC, Sotiras A, Michael AM, et al. Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach. Neuropsychopharmacology. 2023;48:317–26.

Article  PubMed  Google Scholar 

Kalantar-Hormozi H, Patel R, Dai A, Ziolkowski J, Dong H-M, Holmes A, et al. A cross-sectional and longitudinal study of human brain development: The integration of cortical thickness, surface area, gyrification index, and cortical curvature into a unified analytical framework. Neuroimage. 2023;268:119885.

Article  PubMed  Google Scholar 

Wang F, Lian C, Wu Z, Zhang H, Li T, Meng Y, et al. Developmental topography of cortical thickness during infancy. Proc Natl Acad Sci. 2019;116:15855–60.

Article  CAS 

Comments (0)

No login
gif