Urinary TIMP-2*IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin

Oeffinger KC, Eshelman DA, Tomlinson GE, Buchanan GR, Foster BM (2000) Grading of late effects in young adult survivors of childhood cancer followed in an ambulatory adult setting. Cancer 88:1687–1695

Article  CAS  PubMed  Google Scholar 

Bottomley SJ, Kassner E (2003) Late effects of childhood cancer therapy. J Pediatr Nurs 18:126–133

Article  PubMed  Google Scholar 

Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS, Schwartz CL, Leisenring W, Robison LL, Childhood Cancer Survivor Study (2006) Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 355:1572–1582

Article  CAS  PubMed  Google Scholar 

Fujieda M, Matsunaga A, Hayashi A, Tauchi H, Chayama K, Sekine T (2009) Children’s toxicology from bench to bed--drug-induced renal injury (2): nephrotoxicity induced by cisplatin and ifosfamide in children. J Toxicol Sci 34(Suppl 2):SP251–S257

Ariceta G, Rodriguez-Soriano J, Vallo A, Navajas A (1997) Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis. Med Pediatr Oncol 28:35–40

Article  CAS  PubMed  Google Scholar 

Goren MP, Wright RK, Horowitz ME (1986) Cumulative renal tubular damage associated with cisplatin nephrotoxicity. Cancer Chemother Pharmacol 18:69–73

Article  CAS  PubMed  Google Scholar 

McMahon KR, Harel-Sterling M, Pizzi M, Huynh L, Hessey E, Zappitelli M (2018) Long-term renal follow-up of children treated with cisplatin, carboplatin, or ifosfamide: a pilot study. Pediatr Nephrol 33:2311–2320

Article  PubMed  Google Scholar 

Skinner R, Parry A, Price L, Cole M, Craft AW, Pearson AD (2009) Persistent nephrotoxicity during 10-year follow-up after cisplatin or carboplatin treatment in childhood: relevance of age and dose as risk factors. Eur J Cancer 45:3213–3219

Article  CAS  PubMed  Google Scholar 

Skinner R, Pearson AD, Price L, Coulthard MG, Craft AW (1992) The influence of age on nephrotoxicity following chemotherapy in children. Br J Cancer 18:S30–S35

CAS  Google Scholar 

Jones CA, McQuillan GM, Kusek JW, Eberhardt MS, Herman WH, Coresh J, Salive M, Jones CP, Agodoa LY (1998) Serum creatinine levels in the US population: third National Health and Nutrition Examination Survey. Am J Kidney Dis 32:992–999

Article  CAS  PubMed  Google Scholar 

Dharnidharka VR, Kwon C, Stevens G (2002) Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 40:221–226

Article  CAS  PubMed  Google Scholar 

Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmele T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA (2013) Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17:R25

Article  PubMed  PubMed Central  Google Scholar 

Meersch M, Schmidt C, Van Aken H, Rossaint J, Gorlich D, Stege D, Malec E, Januszewska K, Zarbock A (2014) Validation of cell-cycle arrest biomarkers for acute kidney injury after pediatric cardiac surgery. PLoS One 9:e110865

Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, Fitzgerald R, Gong MN, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, Letourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Straseski J, Szalados JE, Wilber ST, Walker MG, Wilson J, Wunderink R, Zimmerman J, Kellum JA (2014) Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Respir Crit Care Med 189:932–939

Article  CAS  PubMed  Google Scholar 

Hoste EA, McCullough PA, Kashani K, Chawla LS, Joannidis M, Shaw AD, Feldkamp T, Uettwiller-Geiger DL, McCarthy P, Shi J, Walker MG, Kellum JA (2014) Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. Nephrol Dial Transplant 29:2054–2061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schanz M, Hoferer A, Shi J, Alscher MD, Kimmel M (2017) Urinary TIMP2IGFBP7 for the prediction of platinum-induced acute renal injury. Int J Nephrol Renovasc Dis 10:175–181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Sun Y, Wang S, Dai X, Huang H, Bai Z, Li X, Wang J, Li Y (2019) The effectiveness of urinary TIMP-2 and IGFBP-7 in predicting acute kidney injury in critically ill neonates. Pediatr Res 87:1052–1059

Article  PubMed  Google Scholar 

Abitbol CL, Moxey-Mims M (2016) Chronic kidney disease: low birth weight and the global burden of kidney disease. Nat Rev Nephrol 12:199–200

Article  PubMed  Google Scholar 

Ronco C, Rizo-Topete L, Serrano-Soto M, Kashani K (2017) Pro: prevention of acute kidney injury: time for teamwork and new biomarkers. Nephrol Dial Transplant 32:408–413

Article  CAS  PubMed  Google Scholar 

Department of Health and Human Services (2014) US Food and Drug Administration. Letter to Astute Medical, Inc

Yang Q-h, Liu D-w, Long Y, Liu H-z, Chai W-z, Wang X-T (2009) Acute renal failure during sepsis: potential role of cell cycle regulation. J Infect 58:459–464

Article  PubMed  Google Scholar 

Witzgall R, Brown D, Schwarz C, Bonventre JV (1994) Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 93:2175–2188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodier F, Campisi J, Bhaumik D (2007) Two faces of p53: aging and tumor suppression. Nucleic Acids Res 35:7475–7484

Article  CAS  PubMed  PubMed Central  Google Scholar 

McMahon KR, Rassekh SR, Schultz KR, Blydt-Hansen T, Cuvelier GDE, Mammen C, Pinsk M, Carleton BC, Tsuyuki RT, Ross CJD, Palijan A, Huynh L, Yordanova M, Crepeau-Hubert F, Wang S, Boyko D, Zappitelli M, Applying Biomarkers to Minimize Long-term Effects of Childhood/Adolescent Cancer Treatment Research Study Group (2020) Epidemiologic characteristics of acute kidney injury during cisplatin infusions in children treated for cancer. JAMA Netw Open 3:e203639

Article  PubMed  PubMed Central  Google Scholar 

McMahon KR, Rod Rassekh S, Schultz KR, Pinsk M, Blydt-Hansen T, Mammen C, Tsuyuki RT, Devarajan P, Cuvelier GD, Mitchell LG, Baruchel S, Palijan A, Carleton BC, Ross CJ, Zappitelli M, Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment Research Group (2017) Design and methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) nephrotoxicity study: a prospective observational cohort study. Can J Kidney Health Dis 4:2054358117690338

Article  PubMed  PubMed Central  Google Scholar 

McMahon KR, Chui H, Rassekh SR, Schultz KR, Blydt-Hansen TD, Mammen C, Pinsk M, Cuvelier GDE, Carleton BC, Tsuyuki RT, Ross CJD, Devarajan P, Huynh L, Yordanova M, Crepeau-Hubert F, Wang S, Cockovski V, Palijan A, Zappitelli M (2021) Urine neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 to detect pediatric cisplatin-associated acute kidney injury. Kidney 360(3):37–50. https://doi.org/10.34067/KID.0004802021

Dong L, Ma Q, Bennett M, Devarajan P (2017) Urinary biomarkers of cell cycle arrest are delayed predictors of acute kidney injury after pediatric cardiopulmonary bypass. Pediatr Nephrol 32:2351–2360

Article  PubMed  PubMed Central  Google Scholar 

Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2:1–138

Google Scholar 

Motwani SS, McMahon GM, Humphreys BD, Partridge AH, Waikar SS, Curhan GC (2018) Development and validation of a risk prediction model for acute kidney injury after the first course of cisplatin. J Clin Oncol 36:682–688

Article  CAS  PubMed  PubMed Central  Google Scholar 

(2010) Common terminology criteria for adverse events (CTCAE), Version 4.0. National Institutes of Health National Cancer Institute, pp 1–194

DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845

Article  CAS  PubMed  Google Scholar 

Bojan M, Pieroni L, Semeraro M, Froissart M (2020) Cell-cycle arrest biomarkers: usefulness for cardiac surgery-related acute kidney injury in neonates and infants. Pediatr Crit Care Med 21:563–570

Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD, TRIBE-AKI Consortium (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol 22:1737–1747

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parikh CR, Thiessen-Philbrook H, Garg AX, Kadiyala D, Shlipak MG, Koyner JL, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Coca SG, TRIBE-AKI Consortium (2013) Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol 8:1079–1088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P, Parikh CR, Goldstein SL (2007) Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care 11:R84

Article  PubMed  PubMed Central  Google Scholar 

Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231–1238

Article  CAS  PubMed  Google Scholar 

Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV (2008) Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int 73:863–869

Article  CAS  PubMed  Google Scholar 

Goldstein SL (2010) Urinary kidney injury biomarkers and urine creatinine normalization: a false premise or not? Kidney Int 78:433–435

Article  CAS  PubMed 

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