Positioning the role of urine cytology within the diagnostic pathway for UTUC: supportive but inconclusive

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ, Cancer Statistics (2009) Both sexes female both sexes estimated deaths. CA Cancer J Clin 59(4):1–25

Google Scholar 

Rouprêt, M., et al. EAU Guidelines on Urothelial Carcinomas of the Upper Urinary Tract 2023. Edn. presented at the 38th EAU Annual Congress Milan. European Association of Urology Guidelines Office Arnhem, The Netherlands.

Seisen T, Peyronnet B, Dominguez-Escrig JL, Bruins HM, Yuan CY, Babjuk M et al (2016) Oncologic outcomes of Kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU Non-muscle invasive bladder cancer guidelines panel. Eur Urol 70(6):1052–1068

Article  Google Scholar 

Xu AD, Ng CS, Kamat A, Grossman HB, Dinney C, Sandler CM (2010) Significance of upper urinary tract urothelial thickening and filling defect seen on MDCT urography in patients with a history of urothelial neoplasms. Am J Roentgenol 195(4):959–965

Article  Google Scholar 

Grahn A, Melle-Hannah M, Malm C, Jäderling F, Radecka E, Beckman M et al (2017) Diagnostic accuracy of computed tomography urography and visual assessment during ureterorenoscopy in upper tract urothelial carcinoma. BJU Int 119(2):289–297

Article  Google Scholar 

Cowan NC, Turney BW, Taylor NJ, McCarthy CL, Crew JP (2007) Multidetector computed tomography urography for diagnosing upper urinary tract urothelial tumour. BJU Int 99(6):1363–1370. https://doi.org/10.1111/j.1464-410X.2007.06766.x

Article  Google Scholar 

Fritz GA, Schoellnast H, Deutschmann HA, Quehenberger F, Tillich M (2006) Multiphasic multidetector-row CT [MDCT] in detection and staging of transitional cell carcinomas of the upper urinary tract. Eur Radiol 16(6):1244–1252

Article  Google Scholar 

Coleman JA, Clark PE, Bixler BR et al (2023) Diagnosis and management of non-metastatic upper tract urothelial carcinoma: AUA/SUO guideline. J Urol 209(6):1071–1081

Article  Google Scholar 

Gontero, P., et al. Guidelines on Non-muscle-invasive Bladder Cancer [T1, T1 and CIS], in EAU Guidelines, Edn. presented at the 38th EAU Annual Congress Milan. 2023, EAU Guidelines Office, Arnhem, The Netherlands.

Yafi FA, Brimo F, Steinberg J, Aprikian AG, Tanguay S, Kassouf W (2015) Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer. Urol Oncol Semin Orig Investig 33(2):66.e25-66.e31

Google Scholar 

Têtu B. Diagnosis of urothelial carcinoma from urine. Mod Pathol. 2009;22[October 2008]:S53–9.

Messer J, Shariat SF, Brien JC, Herman MP, Ng CK, Scherr DS et al (2011) Urinary cytology has a poor performance for predicting invasive or high-grade upper-tract urothelial carcinoma. BJU Int 108(5):701–705

Article  Google Scholar 

Lodde M, Mian C, Wiener H, Haitel A, Pycha A, Marberger M (2001) Detection of upper urinary tract transitional cell carcinoma with ImmunoCyt: A preliminary report. Urology 58(3):362–366

Article  CAS  Google Scholar 

Dev HS, Poo S, Armitage J, Wiseman O, Shah N, Al-Hayek S (2017) Investigating upper urinary tract urothelial carcinomas: a single-centre 10-year experience. World J Urol 35(1):131–138. https://doi.org/10.1007/s00345-016-1820-8. (Epub 2016 Apr 29 PMID: 27129575)

Article  CAS  Google Scholar 

Epstein JI, Eble JN, Sauter G, Sesterhenn IA, (2004). World Health Organization Classification of tumors: pathology and genetics of tumours of the urinary system and male genital organs World Health Organization Classification of tumors: pathology and genetics of tumours of the urinary system and male genital organs.

Baard J, Shariat SF, Roupret M et al (2022) Adherence to guideline recommendations in the management of upper tract urothelial carcinoma: an analysis of the CROES–UTUC registry. World J Urol 40:2755–2763. https://doi.org/10.1007/s00345-022-04168-z

Article  CAS  Google Scholar 

Potretzke AM, Knight BA, Vetter JM, Anderson BG, Hardi AC, Bhayani SB, Figenshau RS (2016) Diagnostic utility of selective upper tract urinary cytology: a systematic review and meta-analysis of the literature. Urology 96:35–43. https://doi.org/10.1016/j.urology.2016.04.030. (Epub 2016 May 2)

Article  Google Scholar 

Freund JE, Duivenvoorden MJC., Sikma BT, Vernooij RWM, Savci-Heijink CD, Legemate JD, de Reijke TM (2020) The Diagnostic yield and concordance of ureterorenoscopic biopsies for grading of upper tract urothelial carcinoma: a dutch nationwide analysis. J Endourology. https://doi.org/10.1089/end.2020.0246

Article  Google Scholar 

Zhang ML, Rosenthal DL, VandenBussche CJ (2017) Upper urinary tract washings outperform voided urine specimens to detect upper tract high-grade urothelial carcinoma. Diagn Cytopathol 45(8):700–704

Article  Google Scholar 

Bibbo M, Gill WB, Harris MJ, Thomsen SWG (1974) Retrograde brushing as a diagnostic procedure of ureteral, renal pelvic and renal calyceal lesions. a preliminary report. Acta Cytol 18(2):137–41

CAS  Google Scholar 

Malm C, Grahn A, Jaremko G, Tribukait B, Brehmer M (2017) Diagnostic accuracy of upper tract urothelial carcinoma: how samples are collected matters. Scand J Urol 51(2):137–145

Article  Google Scholar 

Hentschel AE, van der Toom EE, Vis AN, Ket JCF, Bosschieter J, Heymans MW, van Moorselaar RJA, Steenbergen RDM, Nieuwenhuijzen JA (2021) A systematic review on mutation markers for bladder cancer diagnosis in urine. BJU Int 127(1):12–27. https://doi.org/10.1111/bju.15137. (Epub 2020 Aug 16)

Article  Google Scholar 

Territo A, Gallioli A, Diana P, Boissier R, Fontana M, Gaya JM, Sanguedolce F, Calderón J, Piana A, Fontanet S, Algaba F, Palou J, Breda A (2022) DNA Methylation urine biomarkers test in the diagnosis of upper tract urothelial carcinoma: results from a single-center prospective clinical trial. J Urol 208(3):570–579. https://doi.org/10.1097/JU.0000000000002748. (Epub 2022 May 12)

Article  Google Scholar 

Ghoreifi A, Seyedian SL, Piatti P, Chew YC, Jara B, Sanossian L, Bhasin JM, Yamada T, Fuchs G, Bhanvadia S, Sotelo R, Hung A, Aron M, Desai M, Gill I, Daneshmand S, Liang G, Djaladat H. (1974)A Urine-based DNA Methylation Marker Test to Detect Upper Tract Urothelial Carcinoma: A Prospective Cohort Study. J Urol

Skolarikos A, Griffiths TR, Powell PH, Thomas DJ, Neal DE, Kelly JD (2003) Cytologic analysis of ureteral washings is informative in patients with grade 2 upper tract TCC considering endoscopic treatment. Urology 61(6):1146–1150. https://doi.org/10.1016/s0090-4295[03]00026-8

Article  CAS  Google Scholar 

Renshaw AA (2006) Comparison of ureteral washing and biopsy specimens in the community setting. Cancer 108(1):45–48. https://doi.org/10.1002/cncr.21456. (PMID: 16302250)

Article  Google Scholar 

Zhao Y, Deng FM, Melamed J, Huang WC, Huang H, Ren Q (2021) Diagnostic role of urine cytology and ureteroscopic biopsies in detection of high grade upper tract urothelial carcinoma. Am J Clin Exp Urol 9(3):221–228

Google Scholar 

Comments (0)

No login
gif