Post-infection erectile dysfunction risk - comparing COVID-19 with other common acute viral infections: a large national claims database analysis

Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181:1016–1035.e19. https://doi.org/10.1016/j.cell.2020.04.035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nägele MP, Haubner B, Tanner FC, Ruschitzka F, Flammer AJ. Endothelial dysfunction in COVID-19: Current findings and therapeutic implications. Atherosclerosis. 2020;314:58–62. https://doi.org/10.1016/j.atherosclerosis.2020.10.014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu KY, Nackeeran S, Horodyski L, Masterson TA, Ramasamy R. COVID-19 infection is associated with new onset erectile dysfunction: insights from a national registry. Sex Med. 2022;10:100478 https://doi.org/10.1016/j.esxm.2021.100478

Article  PubMed  Google Scholar 

Hebert KJ, Matta R, Horns JJ, Paudel N, Das R, McCormick BJ, et al. Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction. Int J Impot Res. 2023:1–5. https://doi.org/10.1038/s41443-023-00687-4

Nassau DE, Best JC, Kresch E, Gonzalez DC, Khodamoradi K, Ramasamy R. Impact of the SARS-CoV-2 virus on male reproductive health. BJU Int. 2022;129:143–50. https://doi.org/10.1111/bju.15573

Article  CAS  PubMed  Google Scholar 

Sansone A, Mollaioli D, Ciocca G, Limoncin E, Colonnello E, Vena W, et al. Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. J Endocrinol Invest. 2021;44:223–31. https://doi.org/10.1007/s40618-020-01350-1

Article  CAS  PubMed  Google Scholar 

Fusco F, D’Anzeo G, Rossi A, Sciorio C, Buonomo AR, d’Emmanuele di Villa Bianca R, et al. Erectile dysfunction in patients with chronic viral hepatitis: a systematic review of the literature. Expert Opin Pharmacother. 2013;14:2533–44. https://doi.org/10.1517/14656566.2013.850073

Article  PubMed  Google Scholar 

Klein RS, Lo Y, Santoro N, Dobs AS. Androgen levels in older men who have or who are at risk of acquiring HIV infection. Clin Infect Dis Publ Infect Dis Soc Am. 2005;41:1794–803. https://doi.org/10.1086/498311

Article  CAS  Google Scholar 

Mäkelä S, Jaatinen P, Miettinen M, Salmi J, Ala-Houhala I, Huhtala H, et al. Hormonal deficiencies during and after Puumala hantavirus infection. Eur J Clin Microbiol Infect Dis. 2010;29:705–13. https://doi.org/10.1007/s10096-010-0918-y

Article  PubMed  Google Scholar 

Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: clinical implications. Allergy Asthma Proc. 2019;40:84–92. https://doi.org/10.2500/aap.2019.40.4202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaynar M, Gomes ALQ, Sokolakis I, Gül M. Tip of the iceberg: erectile dysfunction and COVID-19. Int J Impot Res. 2022;34:152–7. https://doi.org/10.1038/s41443-022-00540-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kresch E, Achua J, Saltzman R, Khodamoradi K, Arora H, Ibrahim E, et al. COVID-19 endothelial dysfunction can cause erectile dysfunction: histopathological, immunohistochemical, and ultrastructural study of the human penis. World J Mens Health. 2021;39:466–9. https://doi.org/10.5534/wjmh.210055

Article  PubMed  PubMed Central  Google Scholar 

Golan R, Muthigi A, Ramasamy R. Pro: does COVID affect male reproductive health? J Urol. 2022;208:786–7. https://doi.org/10.1097/JU.0000000000002846

Article  PubMed  Google Scholar 

Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection. Crit Care. 2020;24:353 https://doi.org/10.1186/s13054-020-03062-7

Article  PubMed  PubMed Central  Google Scholar 

Marchenko V, Zelinskaya I, Toropova Y, Shmakova T, Podyacheva E, Lioznov D, et al. Influenza A virus causes histopathological changes and impairment in functional activity of blood vessels in different vascular beds. Viruses. 2022;14:396 https://doi.org/10.3390/v14020396

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee CG, Yoon HJ, Zhu Z, Link H, Wang Z, Galtney JM, et al. Respiratory syncytial virus stimulation of vascular endothelial cell growth Factor/Vascular permeability factor. Am J Respir Cell Mol Biol. 2000;23:662–9. https://doi.org/10.1165/ajrcmb.23.5.4188

Article  CAS  PubMed  Google Scholar 

Madjid M, Aboshady I, Awan I, Litovsky S, Casscells SW. Influenza and cardiovascular disease: is there a causal relationship? Tex Heart Inst J. 2004;31:4–13.

PubMed  PubMed Central  Google Scholar 

Paudel V. Erectile dysfunction secondary to herpes zoster. J Nepal Health Res Counc. 2020;17:556–7. https://doi.org/10.33314/jnhrc.v17i4.2174

Article  PubMed  Google Scholar 

Rix GH, Carroll DN, MacFarlane JR. Herpes zoster producing temporary erectile dysfunction. Int J Impot Res. 2001;13:352–3. https://doi.org/10.1038/sj.ijir.3900786

Article  CAS  PubMed  Google Scholar 

Erol B, Avci A, Eken C, Ozgok Y. Urinary retention, erectile dysfunction and meningitis due to sacral herpes zoster: a case report and review of the literature. Urol Int. 2009;82:238–41. https://doi.org/10.1159/000200807

Article  CAS  PubMed  Google Scholar 

Kim M, Kim SY, Rou WS, Hwang SW, Lee BS. Erectile dysfunction in patients with liver disease related to chronic hepatitis B. Clin Mol Hepatol. 2015;21:352–7. https://doi.org/10.3350/cmh.2015.21.4.352

Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Jiang C, Cheng X, Ma L, Xin Y, Liu T, et al. Secondary hypogonadism following hand, foot, and mouth disease in an adult: a case report and review of literature. BMC Infect Dis. 2022;22:56 https://doi.org/10.1186/s12879-022-07030-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hutt-Fletcher LM. The long and complicated relationship between epstein-barr virus and epithelial cells. J Virol. 2017;91:e01677–16. https://doi.org/10.1128/JVI.01677-16

Article  PubMed  Google Scholar 

DeLay KJ, Haney N, Hellstrom WJ. Modifying risk factors in the management of erectile dysfunction: a review. World J Mens Health. 2016;34:89–100. https://doi.org/10.5534/wjmh.2016.34.2.89

Article  PubMed  PubMed Central  Google Scholar 

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