Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus

Semaan MT, Megerian CA (2006) The pathophysiology of cholesteatoma. Otolaryngol Clin North Am 39:1143–1159

Article  PubMed  Google Scholar 

Aquino JE, Cruz Filho NA, de Aquino JN (2011) Epidemiology of middle ear and mastoid cholesteatomas: study of 1146 cases. Braz J Otorhinolaryngol 77:341–347

Article  PubMed  Google Scholar 

Yung M, Tono T, Olszewska E, Yamamoto Y, Sudhoff H, Sakagami M, Mulder J, Kojima H, İncesulu A, Trabalzini F, Özgirgin N (2017) EAONO/JOS Joint Consensus Statements on the Definitions, Classification and Staging of Middle Ear Cholesteatoma. J Int Adv Otol 13:1–8

Article  PubMed  Google Scholar 

Rosito LS, Netto LS, Teixeira AR, da Costa SS (2016) Sensorineural Hearing Loss in Cholesteatoma. Otol Neurotol 37:214–217

Article  PubMed  Google Scholar 

Falcioni M, Taibah A, Rohit, (2004) Pulsatile tinnitus as a rare presenting symptom of residual cholesteatoma. J Laryngol Otol 118:165–166

Article  CAS  PubMed  Google Scholar 

Hamed MA, Nakata S, Sayed RH, Ueda H, Badawy BS, Nishimura Y, Kojima T, Iwata N, Ahmed AR, Dahy K, Kondo N, Suzuki K (2016) Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives. Clin Exp Otorhinolaryngol 9:298–308

Article  PubMed  PubMed Central  Google Scholar 

Marenda SA, Aufdemorte TB (1995) Localization of cytokines in cholesteatoma tissue. Otolaryngol Head Neck Surg 112:359–368

Article  CAS  PubMed  Google Scholar 

Hamed MA, Nakata S, Shiogama K, Suzuki K, Sayed RH, Nishimura Y, Iwata N, Sakurai K, Badawy BS, Inada KI, Tsuge H, Tsutsumi Y (2017) Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity. Clin Exp Otorhinolaryngol 10:213–220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong JH, Park CW, Tae K, Lee SH, Shin DH, Kim KR, Park YW (2006) Expression of RANKL and OPG in middle ear cholesteatoma tissue. Laryngoscope 116:1180–1184

Article  CAS  PubMed  Google Scholar 

Peek FAW, Huisman MA, Berckmans RJ, Sturk A, Van Loon J, Grote JJ (2003) Lipopolysaccharide concentration and bone resorption in cholesteatoma. Otol Neurotol 24:709–713

Article  CAS  PubMed  Google Scholar 

Schurmann M, Oppel F, Shao S, Volland-Thurn V, Kaltschmidt C, Kaltschmidt B, Scholtz LU, Sudhoff H (2021) Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism. Cell Commun Signal 19:25

Article  PubMed  PubMed Central  Google Scholar 

Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, Yari S, Sato T, Kamakura T, Oshima K, Imai R, Liu YC, Okuzaki D, Hara T, Motooka D, Emoto N, Inohara H, Ishii M (2023) Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun 14:4417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rolvien T, Schmidt FN, Milovanovic P, Jahn K, Riedel C, Butscheidt S, Puschel K, Jeschke A, Amling M, Busse B (2018) Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis. Sci Rep 8:1920

Article  PubMed  PubMed Central  Google Scholar 

Palumbo C, Cavani F, Sena P, Benincasa M, Ferretti M (2012) Osteocyte apoptosis and absence of bone remodeling in human auditory ossicles and scleral ossicles of lower vertebrates: a mere coincidence or linked processes? Calcif Tissue Int 90:211–218

Article  CAS  PubMed  Google Scholar 

Kanzaki S, Takada Y, Ogawa K, Matsuo K (2009) Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerin. J Bone Miner Res 24:43–49

Article  CAS  PubMed  Google Scholar 

Lysaght AC, Yuan Q, Fan Y, Kalwani N, Caruso P, Cunnane M, Lanske B, Stankovic KM (2014) FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice. PLoS ONE 9:e107681

Article  PubMed  PubMed Central  Google Scholar 

Kanzaki S, Ito M, Takada Y, Ogawa K, Matsuo K (2006) Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin. Bone 39:414–419

Article  CAS  PubMed  Google Scholar 

Delsmann MM, Seist R, Stürznickel J, Schmidt FN, Mansour A, Kobelski MM, Broocks G, Peichl J, Oheim R, Praetorius M, Schinke T, Amling M, Demay MB, Stankovic KM, Rolvien T (2021) Conductive Hearing Loss in the Hyp Mouse Model of X-Linked Hypophosphatemia Is Accompanied by Hypomineralization of the Auditory Ossicles. J Bone Miner Res 36:2317–2328

Article  CAS  PubMed  Google Scholar 

Tucci DL, Doherty JK (2019) Contributions of Contemporary Human Temporal Bone Histopathology to Clinical Otology. Otolaryngol Head Neck Surg 161:725–733

Article  PubMed  Google Scholar 

Pueschel K, Heinemann A, Dietz E, Hellwinkel O, Henners D, Fitzek A (2020) New developments and possibilities in the field of post-mortem medicine mortui vivos docent. Rechtsmedizin 30:425–429

Article  Google Scholar 

van Lenthe GH, Hagenmuller H, Bohner M, Hollister SJ, Meinel L, Muller R (2007) Nondestructive micro-computed tomography for biological imaging and quantification of scaffold-bone interaction in vivo. Biomaterials 28:2479–2490

Article  PubMed  Google Scholar 

Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T (2011) Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol 192:1057–1072

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dempster DW, Compston JE, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR, Parfitt AM (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28:2–17

Article  PubMed  Google Scholar 

Busse B, Djonic D, Milovanovic P, Hahn M, Puschel K, Ritchie RO, Djuric M, Amling M (2010) Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell 9:1065–1075

Article  CAS  PubMed  Google Scholar 

Koehne T, Vettorazzi E, Kusters N, Luneburg R, Kahl-Nieke B, Puschel K, Amling M, Busse B (2014) Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years. Bone 66:31–38

Article  CAS  PubMed  Google Scholar 

Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319–326

Article  CAS  PubMed  Google Scholar 

Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671–675

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan ZF, Smith P, Rauch F, Harris GF (2007) Nanoindentation as a means for distinguishing clinical type of osteogenesis imperfecta. Compos B 38:411–415

Article  Google Scholar 

Relucenti M, Miglietta S, Bove G, Donfrancesco O, Battaglione E, Familiari P, Barbaranelli C, Covelli E, Barbara M, Familiari G (2020) SEM BSE 3D image analysis of human incus bone affected by cholesteatoma ascribes to osteoclasts the bone erosion and VpSEM dEDX analysis reveals new bone formation. Scanning 2020:9371516

Article  PubMed  PubMed Central  Google Scholar 

Imai R, Sato T, Iwamoto Y, Hanada Y, Terao M, Ohta Y, Osaki Y, Imai T, Morihana T, Okazaki S, Oshima K, Okuzaki D, Katayama I, Inohara H (2019) Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling. J Assoc Res Otolaryngol 20:449–459

Article  PubMed  PubMed Central  Google Scholar 

Wiatr A, Strek P, Wiatr M (2021) Patterns of bone damage in patients with chronic middle ear inflammation. Ear Nose Throat J 100:NP438–NP443

Article  Google Scholar 

Koizumi H, Suzuki H, Kawaguchi R, Hashida K, Hohchi N, Ohkubo JI, Tabata T, Kitamura T (2017) Presence of osteoclasts in middle ear cholesteatoma: a study of undecalcified bone sections. Acta Otolaryngol 137:127–130

Article  PubMed  Google Scholar 

Manolagas SC (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115–137

CAS  PubMed  Google Scholar 

Duboeuf F, Burt-Pichat B, Farlay D, Suy P, Truy E, Boivin G (2015) Bone quality and biomechanical function: a lesson from human ossicles. Bone 73:105–110

Article  PubMed  Google Scholar 

Martins O, Victor J, Selesnick S (2012) The relationship between individual ossicular status and conductive hearing loss in cholesteatoma. Otol Neurotol 33:387–392

Article  PubMed  Google Scholar 

Yoon TH, Lee SH, Park MH, Chung JW, Kim HJ (2001) Inhibition of cholesteatomatous bone resorption with pamidronate disodium. Acta Otolaryngol 121:178–181

Article  CAS  PubMed 

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