Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 2011;1:a006189.

Article  PubMed  PubMed Central  Google Scholar 

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14:535–62.

Article  PubMed  PubMed Central  Google Scholar 

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, et al. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation. Alzheimers Dement (Amst). 2016;2:27–38.

Article  PubMed  Google Scholar 

Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, et al. Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016;12:292–323.

Article  PubMed  PubMed Central  Google Scholar 

Counts SEIM, Mercado N, Vega IE, Mufson EJ. Biomarkers for the early detection and progression of Alzheimer’s Disease. Neurotherapeutics. 2017;14:35–53.

Article  CAS  PubMed  Google Scholar 

Counts SE, Ikonomovic MD, Mercado N, Vega IE, Mufson EJ. Biomarkers for the early detection and progression of Alzheimer’s disease. Neurotherapeutics. 2017;14:35–53.

Article  CAS  PubMed  Google Scholar 

Ryan NS, Keihaninejad S, Shakespeare TJ, Lehmann M, Crutch SJ, Malone IB, et al. Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer’s disease. Brain. 2013;136:1399–414.

Article  PubMed  PubMed Central  Google Scholar 

Frisoni GB, Fox NC, Jack CR Jr, Scheltens P, Thompson PM. The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol. 2010;6:67–77.

Article  PubMed  PubMed Central  Google Scholar 

Yi SY, Stowe NA, Barnett BR, Dodd K, Yu JJ. Microglial density alters measures of axonal integrity and structural connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5:1061–8.

PubMed  PubMed Central  Google Scholar 

Jagust W. Imaging the evolution and pathophysiology of Alzheimer disease. Nat Rev Neurosci. 2018;19:687–700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Serra L, Cercignani M, Lenzi D, Perri R, Fadda L, Caltagirone C, et al. Grey and white matter changes at different stages of Alzheimer’s disease. J Alzheimers Dis. 2010;19:147–59.

Article  PubMed  Google Scholar 

Aung WY, Mar S, Benzinger TL. Diffusion tensor MRI as a biomarker in axonal and myelin damage. Imaging Med. 2013;5:427–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knight MJ, Wearn A, Coulthard E, Kauppinen RA. T2 Relaxometry and diffusion tensor indices of the hippocampus and entorhinal cortex improve sensitivity and specificity of MRI to detect amnestic mild cognitive impairment and Alzheimer’s disease dementia. J Magn Reson Imaging. 2019;49:445–55.

Article  PubMed  Google Scholar 

Mole JP, Fasano F, Evans J, Sims R, Hamilton DA, Kidd E, et al. Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. Neurobiol Aging. 2020;94:298–310.

Article  CAS  PubMed  Google Scholar 

Montal V, Vilaplana E, Alcolea D, Pegueroles J, Pasternak O, González-Ortiz S, et al. Cortical microstructural changes along the Alzheimer’s disease continuum. Alzheimers Dement. 2018;14:340–51.

Article  PubMed  Google Scholar 

Le Bihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci. 2003;4:469–80.

Article  PubMed  Google Scholar 

Edwards LJ, Kirilina E, Mohammadi S, Weiskopf N. Microstructural imaging of human neocortex in vivo. Neuroimage. 2018;182:184–206.

Article  PubMed  Google Scholar 

Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage. 2012;61:1000–16.

Article  PubMed  Google Scholar 

Nazeri A, Chakravarty MM, Rotenberg DJ, Rajji TK, Rathi Y, Michailovich OV, et al. Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan. J Neurosci. 2015;35:1753–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parker TD, Slattery CF, Zhang J, Nicholas JM, Paterson RW, Foulkes AJM, et al. Cortical microstructure in young onset Alzheimer’s disease using neurite orientation dispersion and density imaging. Hum Brain Mapp. 2018;39:3005–17.

Article  PubMed  PubMed Central  Google Scholar 

Vogt NM, Hunt JF, Adluru N, Dean DC, Johnson SC, Asthana S, et al. Cortical microstructural alterations in mild cognitive impairment and Alzheimer’s disease dementia. Cerebral cortex (New York, NY : 1991). 2020;30:2948–60.

Google Scholar 

Nazeri A, Mulsant BH, Rajji TK, Levesque ML, Pipitone J, Stefanik L, et al. Gray matter neuritic microstructure deficits in schizophrenia and bipolar disorder. Biol Psychiatry. 2017;82:726–36.

Article  PubMed  Google Scholar 

Kamagata K, Zalesky A, Hatano T, Ueda R, Di Biase MA, Okuzumi A, et al. Gray matter abnormalities in idiopathic parkinson’s disease: evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging. Hum Brain Mapp. 2017;38:3704–22.

Article  PubMed  PubMed Central  Google Scholar 

Rossini PM, Rossi S, Babiloni C, Polich J. Clinical neurophysiology of aging brain: from normal aging to neurodegeneration. Prog Neurobiol. 2007;83:375–400.

Article  CAS  PubMed  Google Scholar 

Vogt NM, Hunt JFV, Adluru N, Ma Y, Van Hulle CA, Iii DCD, et al. Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults. Alzheimers Dement. 2022;18(1):65–76. https://doi.org/10.1002/alz.12364.

Article  CAS  PubMed  Google Scholar 

Koscik RL, La Rue A, Jonaitis EM, Okonkwo OC, Johnson SC, Bendlin BB, et al. Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer’s prevention. Dement Geriatr Cogn Disord. 2014;38:16–30.

Article  PubMed  Google Scholar 

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, et al. Mild Cognitive impairment in late middle age in the wisconsin registry for alzheimer’s prevention study: prevalence and characteristics using robust and standard neuropsychological normative data. Arch Clin Neuropsychol. 2016;31:675–88.

Article  PubMed  PubMed Central  Google Scholar 

De Santi S, Pirraglia E, Barr W, Babb J, Williams S, Rogers K, et al. Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline. Neuropsychology. 2008;22:469–84.

Article  PubMed  PubMed Central  Google Scholar 

Johnson SC, Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Berman SE, et al. The wisconsin registry for alzheimer’s prevention: a review of findings and current directions. Alzheimers Dement (Amst). 2017;10:130–42.

Article  PubMed  Google Scholar 

Van Hulle C, Jonaitis EM, Betthauser TJ, Batrla R, Wild N, Kollmorgen G, et al. An examination of a novel multipanel of CSF biomarkers in the Alzheimer’s disease clinical and pathological continuum. Alzheimers Dement. 2021;17:431–45.

Article  PubMed  Google Scholar 

Andersson JLR, Sotiropoulos SN. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage. 2016;125:1063–78.

Article  PubMed  Google Scholar 

Garyfallidis E, Brett M, Amirbekian B, Rokem A, van der Walt S, Descoteaux M, et al. Dipy, a library for the analysis of diffusion MRI data. Front Neuroinform. 2014;8:8.

Article  PubMed  PubMed Central  Google Scholar 

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. FSL Neuroimage. 2012;62:782–90.

Article  PubMed  Google Scholar 

Tournier JD, Smith R, Raffelt D, Tabbara R, Dhollander T, Pietsch M, Christiaens D, et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019;202:116137. https://doi.org/10.1016/j.neuroimage.2019.116137.

Daducci A, Canales-Rodríguez EJ, Zhang H, Dyrby TB, Alexander DC, Thiran JP. Accelerated microstructure imaging via convex optimization (AMICO) from diffusion MRI data. Neuroimage. 2015;105:32–44.

Article  PubMed  Google Scholar 

Fukutomi H, Glasser MF, Zhang H, Autio JA, Coalson TS, Okada T, et al. Neurite imaging reveals microstructural variations in human cerebral cortical gray matter. Neuroimage. 2018;182:488–99.

Article  PubMed  Google Scholar 

Slattery CF, Zhang J, Paterson RW, Foulkes AJM, Carton A, Macpherson K, et al. ApoE influences regional white-matter axonal density loss in Alzheimer’s disease. Neurobiol Aging. 2017;57:8–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown CA, Jiang Y, Smith CD, Gold BT. Age and Alzheimer’s pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities. Cortex. 2018;104:58–74.

Article  PubMed  PubMed Central