Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601
Beach TG, Adler CH (2018) Importance of low diagnostic accuracy for early Parkinson’s disease. Mov Disord 33:1551–1554
Article PubMed PubMed Central Google Scholar
Espay AJ, Schwarzschild MA, Tanner CM, Fernandez HH, Simon DK, Leverenz JB et al (2017) Biomarker-driven phenotyping in Parkinson’s disease: A translational missing link in disease-modifying clinical trials. Mov Disord 32:319–324
Article PubMed PubMed Central Google Scholar
Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM et al (2008) Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods 5:211–212
Article CAS PubMed Google Scholar
Mammana A, Baiardi S, Quadalti C, Rossi M, Donadio V, Capellari S et al (2021) RT-QuIC detection of pathological α-synuclein in skin punches of patients with Lewy body disease. Mov Disord 36:2173–2177
Article CAS PubMed PubMed Central Google Scholar
Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A et al (2020) α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson’s disease patients. Mov Disord 35:268–278
Article CAS PubMed Google Scholar
De Luca CMG, Elia AE, Portaleone SM, Cazzaniga FA, Rossi M, Bistaffa E et al (2019) Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy. Transl Neurodegener 8:24
Article PubMed PubMed Central Google Scholar
Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S et al (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Ann Clin Transl Neurol 3:812–818
Article CAS PubMed PubMed Central Google Scholar
Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X et al (2020) Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy. Nature 578:273–277
Article CAS PubMed PubMed Central Google Scholar
Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B et al (2018) Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathol Commun 6:7
Article PubMed PubMed Central Google Scholar
Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno S-I, Imamichi-Tatano Y et al (2023) Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nat Med 29:1448–1455
Article CAS PubMed PubMed Central Google Scholar
Kluge A, Bunk J, Schaeffer E, Drobny A, Xiang W, Knacke H et al (2022) Detection of neuron-derived pathological α-synuclein in blood. Brain 145:3058–3071
Vivacqua G, Mason M, De Bartolo MI, Węgrzynowicz M, Calò L, Belvisi D et al (2023) Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson’s Disease. Mov Disord 38:153–155
Article CAS PubMed Google Scholar
Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orrù CD et al (2020) Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies. Acta Neuropathol 140:49–62
Article CAS PubMed PubMed Central Google Scholar
Russo MJ, Orru CD, Concha-Marambio L, Giaisi S, Groveman BR, Farris CM et al (2021) High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease. Acta Neuropathol Commun 9:179
Article CAS PubMed PubMed Central Google Scholar
Brockmann K, Quadalti C, Lerche S, Rossi M, Wurster I, Baiardi S et al (2021) Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies. Acta Neuropathol Commun 9:175
Article CAS PubMed PubMed Central Google Scholar
Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL et al (2021) Alpha-Synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure. Ann Neurol 89:1212–1220
Article CAS PubMed PubMed Central Google Scholar
Rossi M, Baiardi S, Teunissen CE, Quadalti C, van de Beek M, Mammana A et al (2021) Diagnostic value of the CSF α-synuclein real-time quaking-induced conversion assay at the prodromal MCI stage of dementia with Lewy bodies. Neurology 97:e930–e940
Article CAS PubMed PubMed Central Google Scholar
Orrù CD, Ma TC, Hughson AG, Groveman BR, Srivastava A, Galasko D et al (2021) A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy. Ann Clin Transl Neurol 8:374–384
Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I et al (2003) SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Mov Disord 18:467–486
McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor J-P, Weintraub D et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology 89:88–100
Article PubMed PubMed Central Google Scholar
Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement disorder society-sponsored revision of the unified Parkinson’s Disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results: MDS-UPDRS: clinimetric Assessment. Mov Disord 23:2129–2170
Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. J Psychiatr Res 12:189–198
Article CAS PubMed Google Scholar
Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB et al (2009) Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 73:1738–1745
Article CAS PubMed PubMed Central Google Scholar
Roheger M, Xu H, Hoang MT, Eriksdotter M, Garcia-Ptacek S (2022) Conversion between the mini-mental state examination and the Montreal cognitive assessment for patients with different forms of dementia. J Am Med Dir Assoc 23:1986-1989.e1
Thomann AE, Berres M, Goettel N, Steiner LA, Monsch AU (2020) Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment. Alzheimers Res Ther 12:39
Article PubMed PubMed Central Google Scholar
Kang UJ, Boehme AK, Fairfoul G, Shahnawaz M, Ma TC, Hutten SJ et al (2019) Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson’s disease. Mov Disord 34:536–544
Article CAS PubMed PubMed Central Google Scholar
McKenzie N, Piconi G, Culeux A, Hammarin A-L, Stergiou C, Tzartos S et al (2022) Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network. Eur J Neurol 29:2431–2438
Article PubMed PubMed Central Google Scholar
Orrú CD, Groveman BR, Foutz A, Bongianni M, Cardone F, McKenzie N et al (2020) Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD. Ann Clin Transl Neurol 7:2262–2271
Article PubMed PubMed Central Google Scholar
Parkkinen L, O’Sullivan SS, Collins C, Petrie A, Holton JL, Revesz T et al (2011) Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson’s disease. J Parkinsons Dis 1:277–286
Article CAS PubMed PubMed Central Google Scholar
Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH et al (2013) Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease. Brain 136:2419–2431
Article PubMed PubMed Central Google Scholar
Regnault A, Boroojerdi B, Meunier J, Bani M, Morel T, Cano S (2019) Does the MDS-UPDRS provide the precision to assess progression in early Parkinson’s disease? Learnings from the Parkinson’s progression marker initiative cohort. J Neurol 266:1927–1936
Article PubMed PubMed Central Google Scholar
Hurtig HI, Trojanowski JQ, Galvin J, Ewbank D, Schmidt ML, Lee VM et al (2000) Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease. Neurology 54:1916–1921
Article CAS PubMed Google Scholar
Mattila PM, Rinne JO, Helenius H, Dickson DW, Röyttä M (2000) Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson’s disease. Acta Neuropathol 100:285–290
Comments (0)