Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601

Article  PubMed  Google Scholar 

Beach TG, Adler CH (2018) Importance of low diagnostic accuracy for early Parkinson’s disease. Mov Disord 33:1551–1554

Article  PubMed  PubMed Central  Google Scholar 

Espay AJ, Schwarzschild MA, Tanner CM, Fernandez HH, Simon DK, Leverenz JB et al (2017) Biomarker-driven phenotyping in Parkinson’s disease: A translational missing link in disease-modifying clinical trials. Mov Disord 32:319–324

Article  PubMed  PubMed Central  Google Scholar 

Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM et al (2008) Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods 5:211–212

Article  CAS  PubMed  Google Scholar 

Mammana A, Baiardi S, Quadalti C, Rossi M, Donadio V, Capellari S et al (2021) RT-QuIC detection of pathological α-synuclein in skin punches of patients with Lewy body disease. Mov Disord 36:2173–2177

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A et al (2020) α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson’s disease patients. Mov Disord 35:268–278

Article  CAS  PubMed  Google Scholar 

De Luca CMG, Elia AE, Portaleone SM, Cazzaniga FA, Rossi M, Bistaffa E et al (2019) Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy. Transl Neurodegener 8:24

Article  PubMed  PubMed Central  Google Scholar 

Fairfoul G, McGuire LI, Pal S, Ironside JW, Neumann J, Christie S et al (2016) Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Ann Clin Transl Neurol 3:812–818

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X et al (2020) Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy. Nature 578:273–277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B et al (2018) Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathol Commun 6:7

Article  PubMed  PubMed Central  Google Scholar 

Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno S-I, Imamichi-Tatano Y et al (2023) Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nat Med 29:1448–1455

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kluge A, Bunk J, Schaeffer E, Drobny A, Xiang W, Knacke H et al (2022) Detection of neuron-derived pathological α-synuclein in blood. Brain 145:3058–3071

Article  PubMed  Google Scholar 

Vivacqua G, Mason M, De Bartolo MI, Węgrzynowicz M, Calò L, Belvisi D et al (2023) Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson’s Disease. Mov Disord 38:153–155

Article  CAS  PubMed  Google Scholar 

Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orrù CD et al (2020) Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies. Acta Neuropathol 140:49–62

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russo MJ, Orru CD, Concha-Marambio L, Giaisi S, Groveman BR, Farris CM et al (2021) High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease. Acta Neuropathol Commun 9:179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brockmann K, Quadalti C, Lerche S, Rossi M, Wurster I, Baiardi S et al (2021) Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies. Acta Neuropathol Commun 9:175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL et al (2021) Alpha-Synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure. Ann Neurol 89:1212–1220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi M, Baiardi S, Teunissen CE, Quadalti C, van de Beek M, Mammana A et al (2021) Diagnostic value of the CSF α-synuclein real-time quaking-induced conversion assay at the prodromal MCI stage of dementia with Lewy bodies. Neurology 97:e930–e940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orrù CD, Ma TC, Hughson AG, Groveman BR, Srivastava A, Galasko D et al (2021) A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy. Ann Clin Transl Neurol 8:374–384

Article  PubMed  Google Scholar 

Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I et al (2003) SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Mov Disord 18:467–486

Article  PubMed  Google Scholar 

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor J-P, Weintraub D et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology 89:88–100

Article  PubMed  PubMed Central  Google Scholar 

Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement disorder society-sponsored revision of the unified Parkinson’s Disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results: MDS-UPDRS: clinimetric Assessment. Mov Disord 23:2129–2170

Article  PubMed  Google Scholar 

Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. J Psychiatr Res 12:189–198

Article  CAS  PubMed  Google Scholar 

Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB et al (2009) Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 73:1738–1745

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roheger M, Xu H, Hoang MT, Eriksdotter M, Garcia-Ptacek S (2022) Conversion between the mini-mental state examination and the Montreal cognitive assessment for patients with different forms of dementia. J Am Med Dir Assoc 23:1986-1989.e1

Article  PubMed  Google Scholar 

Thomann AE, Berres M, Goettel N, Steiner LA, Monsch AU (2020) Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment. Alzheimers Res Ther 12:39

Article  PubMed  PubMed Central  Google Scholar 

Kang UJ, Boehme AK, Fairfoul G, Shahnawaz M, Ma TC, Hutten SJ et al (2019) Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson’s disease. Mov Disord 34:536–544

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenzie N, Piconi G, Culeux A, Hammarin A-L, Stergiou C, Tzartos S et al (2022) Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network. Eur J Neurol 29:2431–2438

Article  PubMed  PubMed Central  Google Scholar 

Orrú CD, Groveman BR, Foutz A, Bongianni M, Cardone F, McKenzie N et al (2020) Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD. Ann Clin Transl Neurol 7:2262–2271

Article  PubMed  PubMed Central  Google Scholar 

Parkkinen L, O’Sullivan SS, Collins C, Petrie A, Holton JL, Revesz T et al (2011) Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson’s disease. J Parkinsons Dis 1:277–286

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH et al (2013) Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease. Brain 136:2419–2431

Article  PubMed  PubMed Central  Google Scholar 

Regnault A, Boroojerdi B, Meunier J, Bani M, Morel T, Cano S (2019) Does the MDS-UPDRS provide the precision to assess progression in early Parkinson’s disease? Learnings from the Parkinson’s progression marker initiative cohort. J Neurol 266:1927–1936

Article  PubMed  PubMed Central  Google Scholar 

Hurtig HI, Trojanowski JQ, Galvin J, Ewbank D, Schmidt ML, Lee VM et al (2000) Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease. Neurology 54:1916–1921

Article  CAS  PubMed  Google Scholar 

Mattila PM, Rinne JO, Helenius H, Dickson DW, Röyttä M (2000) Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson’s disease. Acta Neuropathol 100:285–290

Article  CAS  PubMed 

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