Abdallah IZ (2002) Physiological changes induced by long term administration of saccharin compared with aspartame to male albino rats. The Egypt J Hosp Med 8(1):70-81

Article  Google Scholar 

Abdelaziz I, Ashour AE (2010) Effect of saccharin on albino rats’ blood indices and the therapeutic action of vitamins C and E. Human Exp Toxicol 30(2):129–137

Article  Google Scholar 

Abhilash MMV, Paul S, Varghese MV, Nair RH (2011) Effect of long term intake of aspartame on antioxidant defense status in liver. Food Chem Toxicol 49:1203–1207

Article  CAS  PubMed  Google Scholar 

Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121–126

Article  CAS  PubMed  Google Scholar 

Agamy NF, Ismail H, Youssef MI, Fawzi M (2008) Comparative study on the effects of steviosides and aspartame on glucose, urea and creatinine levels of normal and type 2 diabetic rats. J High Inst Public Health 38:102–112

Article  Google Scholar 

Ali S, Hussain S, Khan R, Mumtaz S, Ashraf N, Andleeb S, Shakir HA, Tahir HM, Khan MKA, Ulhaq M (2019) Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits. Environ Sci Pollut Res 26(4):3909–3920

Article  CAS  Google Scholar 

Ali S, Awan Z, Mumtaz S, Shakir HA, Ahmad F, Tahir HM, Ulhaq M (2020) Cardiac toxicity of heavy metals (cadmium and mercury) and pharmacological intervention by vitamin C in rabbits. Environ Sci Pollut Res Int 27(23):29266–29279

Article  CAS  PubMed  Google Scholar 

Alkafafy MES, Ibrahim ZS, Ahmed MM, El-Shazly SA (2015) Impact of aspartame and saccharin on the rat liver: biochemical, molecular and histological approach. Int J Immunopathol Pharmacol 28:247–255

Article  CAS  PubMed  Google Scholar 

Ara C, Asmatullah BN, Ali S, Batool F, Shakir HA, Arshad A (2020) Abnormal steroidogenesis, oxidative stress and reprotoxicity following prepubertal exposure to butyl paraben in mice and protective effect of Curcuma longa. Environ Sci Pollut. https://doi.org/10.1007/s11356-020-10819-8

Article  Google Scholar 

Ashok I, Sheeladevi R, Wankhar D (2013) Long term effect of aspartame (artificial sweetener) on membrane homeostatic imbalance and histopathology in the rat brain. Free Rad Antioxi 3:S42–S49

CAS  Google Scholar 

Association AD (1998) Use of nutritive and non-nutritive Sweeteners. J Am Diet Assoc 98:580

Google Scholar 

Bellisle F (2015) Intense sweeteners, appetite for the sweet taste, and relationship to weight management. Curr Obes Rep 4(1):106–110

Article  PubMed  PubMed Central  Google Scholar 

Bunout D (1999) Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. Nutrition 15(7–8):583–589

Article  CAS  PubMed  Google Scholar 

Burtis C, Ashwood ER (1999) Fundamental of clinical biochemistry, 4th edn. Saunders Com, New York

Google Scholar 

Chandra J, Samali A, Orrenius S (2000) Triggering and modulation of apoptosis by oxidative stress. Free Rad Bio Med 29:323–333

Article  CAS  Google Scholar 

Dar AA, Arumugam N (2013) Lignans of sesame: purification methods, biological activities and biosynthesis–a review. Bioorg Chem 50:1–10

Article  CAS  PubMed  Google Scholar 

Dar KK, Ali S, Ejaz M, Nasreen S, Ashraf N, Gillani SF, Shafi N, Safeer S, Khan MA, Andleeb S, Mughal TA (2019) In vivo induction of hepatocellular carcinoma by diethylnitrosoamine and pharmacological intervention in balb c mice using Bergenia ciliata extracts. Braz J Biol 79(4):629–638

Article  CAS  PubMed  Google Scholar 

Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, Vasan RS (2007) Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation 116(5):480–488

Article  PubMed  Google Scholar 

El-Sokkary GH, Khidr BM, Saleh SM (2016) Aspartame-induced oxidative stress on liver and kidney in normal and diabetic adult male rats. Ind J Appl Res 6(8):511

Google Scholar 

Fagherazzi G, Vilier A, Saes Sartorelli D, Lajous M, Balkau B, Clavel-Chapelon F (2013) Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l’Education Nationale-European prospective Investigation into cancer and nutrition cohort. Am J Clin Nutr 97:517–523

Article  CAS  PubMed  Google Scholar 

Hassan MI (2016) Low intake of aspartame induced weight gain and damage of brain and liver cells in weanling Syrian hamsters. J Food Nutr Res 4:152–156

CAS  Google Scholar 

Hsu DZ, Li YH, Chu PY, Chien SP, Chuang YC, Liu MY (2006) Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3, 4-methylenedioxyphenol in rats. Shock 25(3):300–305

Article  CAS  PubMed  Google Scholar 

Hussain S, Ali S, Mumtaz S, Shakir HA, Ahmad F, Tahir HM, Ulhaq M (2020) Dose and duration-dependent toxicological evaluation of lead acetate in chicks. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-08016-8

Article  Google Scholar 

Hwang LS (2005) Bailey’s industrial oil and fat products. John Wiley, Hoboken

Google Scholar 

Iman MM (2011) Effect of aspartame on some oxidative stress parameters in liver and kidney of rats. Afr J Pharm Pharmacol 5(6):678–682

Article  Google Scholar 

Kamal IH, Moustafa AF, Abd El-Galil AM, Abdullah NM (2000) Biochemical studies on alitame, a dipeptide non-nutritive sweetener on healthy and diabetic rats compared to aspartame. The New Egypt J Med 23(2):40–47

Google Scholar 

Khan R, Ali S, Mumtaz M, Andleeb S, Ulhaq M, Tahir HM, Khan MKA, Khan MA, Shakir HA (2019) Toxicological effects of heavy metals (cadmium and mercury) on blood and thyroid gland and pharmacological intervention by vitamin c in rabbits. Environ Sci Pollut Res 26(16):16727–16741

Article  CAS  Google Scholar 

Lowry OH, Rosenbrough NJ, Randal RJ (1951) Protein measurement with the Folin-phenol reagent. J Biol Chem 193:265–275

Article  CAS  PubMed  Google Scholar 

Magnuson BA, Burdock G, Doull J, Kroes RM, Marsh GM, Pariza MW, Williams GM (2007) Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Critic Rev Toxicol 37(8):629–727

Article  CAS  Google Scholar 

Magnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG (2016) Biological fate of low-calorie sweeteners. Nutr Rev 74(11):670–689

Article  PubMed  Google Scholar 

Mattes RD, Popkin BM (2009) Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr 89(1):1–14

Article  CAS  PubMed  Google Scholar 

Mazurek S, Szostak R (2011) Quantification of aspartame in commercial sweeteners by FT-Raman spectroscopy. Food Chem 125(3):1051–1057

Article  CAS  Google Scholar 

Mercola J (2006) Sweet deception: why Splenda, Nutrasweet, and the FDA may be hazardous to your health. Thomas Nelson, Nashville

Google Scholar 

Mitra S, Venkataranganna M, Sundaram R, Gopumadhavan S (1998) Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J Ethnopharmacol 63(3):181–186

Article  CAS  PubMed  Google Scholar 

Mughal TA, Saleem MZ, Ali S, Bashir AKK, MM, Babar M, Khan MA, (2019) Evaluation of hepatotoxicity of carbon tetrachloride and pharmacological intervention by vitamin E in balb c mice. Pak J Zoo 51(2):755–761

Article  CAS  Google Scholar 

Mumtaz S, Ali S, Khan R, Andleeb S, Ulhaq M, Khan MA, Shakir HA (2019) The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits. Environ Sci Pollut Res Int 26(14):14087–14096

Article  CAS  PubMed  Google Scholar 

Muriel P (2009) Role of free radicals in liver diseases. Hepatol Int 3(4):526–536

Article  PubMed  PubMed Central  Google Scholar 

Namiki M (1995) The chemistry and physiological functions of sesame. Food Rev Int 11(2):281–329

Article  CAS  Google Scholar 

Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S (2008) The current state of serum biomarkers of hepatotoxicity. Toxicology 245(3):194–205

Article  CAS  PubMed  Google Scholar 

Pohannish RP (2002) Sittig’s handbook of toxic and hazardous chemicals and carcinogens. Noyes/William Andrew, Norwich

Google Scholar 

Prins HK, Loose JA (1969) Glutathione “Chapter 4.” In: Yunis JJ (ed) Biochemical in red cell genetics. Aca-demic Press, London, pp 126–129

Google Scholar 

Prokic M, Paunovic M, Matic M, Djordjevic N, Ognjanovic B, Stajn A, Saicic Z (2015) Effect of aspartame on biochemical and oxidative stress parameters in rat blood. Arch Biol Sci 67(2):535–545

Article  Google Scholar 

Ramesh B, Saravanan R, Pugalendi KV (2005) Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food 8(3):377–381

Article  CAS  PubMed  Google Scholar 

Rycerz K, Jaworska-Adamu JE (2013) Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathol 51(1):10–17

Article  CAS  PubMed  Google Scholar 

Shahdi-Pashaki S, Teymourian E, Tavakkoli-Moghaddam R (2018) New approach based on group technology for the consolidation problemin cloud computing-mathematical model and genetic algorithm. Comput Appl Math 37(1