Kidney Considerations in Pediatric Obesity

Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl. 2022;12(1):7–11.

Article  Google Scholar 

Kibria GMA, Crispen R. Prevalence and trends of chronic kidney disease and its risk factors among US adults: An analysis of NHANES 2003–18. Prev Med Rep. 2020;20:101193.

United States Renal Data System. 2020 USRDS annual data report: epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2020.

Chronic Kidney Disease Surveillance System—United States: Centers for Disease Control and Prevention. 2021. Available from: https://nccd.cdc.gov/ckd/.

Eknoyan G, Lameire N, Eckardt K, Kasiske B, Wheeler D, Levin A, et al. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;3(1):5–14.

Google Scholar 

Harada R, Hamasaki Y, Okuda Y, Hamada R, Ishikura K. Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies. Pediatr Nephrol. 2022:1–15.

Mallamaci F, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, et al. ACE inhibition is renoprotective among obese patients with proteinuria. J Am Soc Nephrol. 2011;22(6):1122–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyrén O. Obesity and risk for chronic renal failure. J Am Soc Nephrol. 2006;17(6):1695–702.

Article  CAS  PubMed  Google Scholar 

Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol. 2005;16(7):2134–40.

Article  PubMed  Google Scholar 

Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, et al. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med. 2004;140(3):167–74.

Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G, et al. Metabolic mediators of the eff ects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. 2014.

Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006;144(1):21–8.

Article  PubMed  Google Scholar 

Wang Y, Chen X, Song Y, Caballero B, Cheskin L. Association between obesity and kidney disease: a systematic review and meta-analysis. Kidney Int. 2008;73(1):19–33.

Article  CAS  PubMed  Google Scholar 

Ladhani M, Lade S, Alexander SI, Baur LA, Clayton PA, McDonald S, et al. Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death. Pediatr Nephrol. 2017;32(8):1443–50.

Article  PubMed  Google Scholar 

Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78.

Article  PubMed  Google Scholar 

Trinchieri A, Croppi E, Montanari E. Obesity and urolithiasis: evidence of regional influences. Urolithiasis. 2017;45(3):271–8.

Article  PubMed  Google Scholar 

Wu C, Wang AY, Li G, Wang L. Association of high body mass index with development of interstitial fibrosis in patients with IgA nephropathy. BMC Nephrol. 2018;19(1):381.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berthoux F, Mariat C, Maillard N. Overweight/obesity revisited as a predictive risk factor in primary IgA nephropathy. Nephrol Dial Transplant. 2013;28 Suppl 4:iv160–6.

Yim HE, Han KD, Kim B, Yoo KH. Impact of early-life weight status on urinary tract infections in children: a nationwide population-based study in Korea. Epidemiol Health. 2021;43: e2021005.

Article  PubMed  Google Scholar 

Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain, and the risk of kidney stones. JAMA. 2005;293(4):455–62.

Article  CAS  PubMed  Google Scholar 

Pourghazi F, Mohammadi S, Eslami M, Zoshk MY, Asadi S, Ejtahed HS, et al. Association between childhood obesity and later life kidney disorders: a systematic review. J Ren Nutr. 2023.

Wei L, Li Y, Yu Y, Xu M, Chen H, Li L, et al. Obesity-related glomerulopathy: from mechanism to therapeutic target. Diabetes Metab Syndr Obes. 2021;14:4371–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Freedman DS, Lawman HG, Galuska DA, Goodman AB, Berenson GS. Tracking and variability in childhood levels of BMI: the Bogalusa Heart Study. Obesity. 2018;26(7):1197–202.

Article  PubMed  Google Scholar 

Singh AS, Mulder C, Twisk JW, Van Mechelen W, Chinapaw MJ. Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev. 2008;9(5):474–88.

Article  CAS  PubMed  Google Scholar 

Stierman B, Afful J, Carroll MD, Chen TC, Davy O, Fink S, Fryar CD, Gu Q, Hales CM, Hughes JP, Ostchega Y. National health and nutrition examination survey 2017–March 2020 prepandemic data files development of files and prevalence estimates for selected health outcomes. 2021.

Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17(2):95–107.

Article  CAS  PubMed  Google Scholar 

Garofalo C, Borrelli S, Minutolo R, Chiodini P, De Nicola L, Conte G. A systematic review and meta-analysis suggests obesity predicts onset of chronic kidney disease in the general population. Kidney Int. 2017;91(5):1224–35.

Article  PubMed  Google Scholar 

Chang A, Van Horn L, Jacobs DR Jr, Liu K, Muntner P, Newsome B, et al. Lifestyle-related factors, obesity, and incident microalbuminuria: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am J Kidney Dis. 2013;62(2):267–75.

Article  PubMed  PubMed Central  Google Scholar 

Ferris M, Hogan SL, Chin H, Shoham DA, Gipson DS, Gibson K, et al. Obesity, albuminuria, and urinalysis findings in US young adults from the Add Health Wave III Study. Clin J Am Soc Nephrol. 2007;2(6):1207–14.

Article  PubMed  Google Scholar 

Vivante A, Golan E, Tzur D, Leiba A, Tirosh A, Skorecki K, et al. Body mass index in 1.2 million adolescents and risk for end-stage renal disease. Arch Intern Med. 2012;172(21):1644–50.

Marzuillo P, Grandone A, Di Sessa A, Guarino S, Diplomatico M, Umano GR, et al. Anthropometric and biochemical determinants of estimated glomerular filtration rate in a large cohort of obese children. J Ren Nutr. 2018;28(5):359–62.

Article  CAS  PubMed  Google Scholar 

Di Bonito P, Licenziati MR, Campana G, Chiesa C, Pacifico L, Manco M, et al. Prevalence of mildly reduced estimated GFR by height- or age-related equations in young people with obesity and its association with cardiometabolic risk factors. J Ren Nutr. 2021;31(6):586–92.

Article  PubMed  Google Scholar 

D’Agati VD, Chagnac A, De Vries AP, Levi M, Porrini E, Herman-Edelstein M, et al. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. 2016;12(8):453–71.

Article  CAS  PubMed  Google Scholar 

Kambham N, Markowitz GS, Valeri AM, Lin J, D’Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001;59(4):1498–509.

Article  CAS  PubMed  Google Scholar 

Tsuboi N, Okabayashi Y, Shimizu A, Yokoo T. The renal pathology of obesity. Kidney Int Rep. 2017;2(2):251–60.

Article  PubMed  PubMed Central  Google Scholar 

Joshi PH, Hill JA. Pound-Years. Circ Res. 2017;120(10):1533–4.

Article  CAS  PubMed  Google Scholar 

Chagnac A, Weinstein T, Korzets A, Ramadan E, Hirsch J, Gafter U. Glomerular hemodynamics in severe obesity. Am J Physiol-Renal Physiol. 2000;278(5):F817–22.

Article  CAS  PubMed  Google Scholar 

Yim HE, Yoo KH. Obesity and chronic kidney disease: prevalence, mechanism, and management. Clin Exp Pediatr. 2021;64(10):511.

Chagnac A, Zingerman B, Rozen-Zvi B, Herman-Edelstein M. Consequences of glomerular hyperfiltration: the role of physical forces in the pathogenesis of chronic kidney disease in diabetes and obesity. Nephron. 2019;143(1):38–42.

Article  CAS  PubMed  Google Scholar 

Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008;118(5):1645–56.

CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Wang Z, Chen Y, Dong Y. Kidney damage caused by obesity and its feasible treatment drugs. Int J Mol Sci. 2022;23(2):747.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mangat G, Nair N, Barat O, Abboud B, Pais P, Bagga S, et al. Obesity-related glomerulopathy in children: connecting pathophysiology to clinical care. Clin Kidney J. 2022.

Rüster C, Wolf G. Adipokines promote chronic kidney disease. Nephrol Dial Transplant. 2013;28 Suppl 4:iv8–14.

Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord. 2004;28(Suppl 4):S58-65.

Article  CAS  PubMed  Google Scholar 

Mykkänen L, Zaccaro DJ, Wagenknecht LE, Robbins DC, Gabriel M, Haffner SM. Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study. Diabetes. 1998;47(5):793–800.

Article  PubMed  Google Scholar 

McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, et al. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. Am J Physiol Renal Physiol. 2016;311(4):F793-f804.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarafidis PA, Ruilope LM. Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications. Am J Nephrol. 2006;26(3):232–44.

Article  PubMed  Google Scholar 

Pantoja Zuzuárregui JR, Mallios R, Murphy J. The effect of obesity on kidney length in a healthy pediatric population. Pediatr Nephrol. 2009;24:2023–7.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif