Wild, C. P. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol. Biomarkers Prev. 14, 1847–1850 (2005).

Article  CAS  PubMed  Google Scholar 

Argentieri, M. A. et al. Integrating the environmental and genetic architectures of aging and mortality. Nat. Med. 31, 1016–1025 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foreman, A. L. et al. Adopting mechanistic molecular biology approaches in exposome research for causal understanding. Environ. Sci. Technol. 58, 7256–7269 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barzilay, R. et al. Exposome and trans-syndromal developmental trajectories toward psychosis. Biol. Psychiatry Glob. Open Sci. 2, 197–205 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ibanez, A. et al. Neuroecological links of the exposome and One Health. Neuron 112, 1905–1910 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, F. et al. Environmental neuroscience linking exposome to brain structure and function underlying cognition and behavior. Mol. Psychiatry 28, 17–27 (2023).

Article  CAS  PubMed  Google Scholar 

Dallere, S. et al. The exposome from neurodevelopment to neurodegeneration: a narrative review. Neurosci. Biobehav. Rev. 176, 106247 (2025).

Article  CAS  PubMed  Google Scholar 

Robinson, H. et al. The effect of the “exposome” on developmental brain health and cognitive outcomes. Neuropsychopharmacology 51, 169–184 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Zhang, P. et al. Defining the scope of exposome studies and research needs from a multidisciplinary perspective. Environ. Sci. Technol. Lett. 8, 839–852 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez, H. et al. The exposome of healthy and accelerated aging across 40 countries. Nat. Med. 31, 3089–3100 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lebow-Skelley, E. et al. Defining the exposome using popular education and concept mapping with communities in Atlanta, Georgia. Front. Public Health 10, 842539 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ibanez, A. Inspired by struggle: a personal journey to global precision brain health. iScience 28, 111918 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Zeng, X., Sun, Y., Zhiying, Z., Hua, L. & Yuan, Z. Chronic pain-induced functional and structural alterations in the brain: a multi-modal meta-analysis. J. Pain 28, 104740 (2025).

Article  PubMed  Google Scholar 

Schwartz, S. S., Herman, M. E., Tun, M. T. H., Barone, E. & Butterfield, D. A. The double life of glucose metabolism: brain health, glycemic homeostasis, and your patients with type 2 diabetes. BMC Med. 22, 582 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakrabarti, A. et al. The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. Cell. Mol. Life Sci. 79, 80 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, Q. et al. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. J. Neuroinflammation 16, 53 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Needham, B. D., Kaddurah-Daouk, R. & Mazmanian, S. K. Gut microbial molecules in behavioural and neurodegenerative conditions. Nat. Rev. Neurosci. 21, 717–731 (2020).

Article  CAS  PubMed  Google Scholar 

Pape, K., Tamouza, R., Leboyer, M. & Zipp, F. Immunoneuropsychiatry — novel perspectives on brain disorders. Nat. Rev. Neurol. 15, 317–328 (2019).

Article  PubMed  Google Scholar 

Kipnis, J. Multifaceted interactions between adaptive immunity and the central nervous system. Science 353, 766–771 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalc, P., Dahnke, R., Hoffstaedter, F. & Gaser, C. Low bone mineral density is associated with gray matter volume decrease in UK Biobank. Front. Aging Neurosci. 15, 1287304 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Li, R. et al. The brain–gut–bone axis in neurodegenerative diseases: insights, challenges, and future prospects. Adv. Sci. 11, 2307971 (2024).

Article  Google Scholar 

Jin, Y., Zhu, D. & He, P. Social causation or social selection? The longitudinal interrelationship between poverty and depressive symptoms in China. Soc. Sci. Med. 249, 112848 (2020).

Article  PubMed  Google Scholar 

Eickhoff, S. B., Yeo, B. T. T. & Genon, S. Imaging-based parcellations of the human brain. Nat. Rev. Neurosci. 19, 672–686 (2018).

Article  CAS  PubMed  Google Scholar 

Ho, T. C. The exposome and the developing adolescent brain: understanding mechanisms of neuroplasticity. Neuropsychopharmacology 51, 328–329 (2026).

Article  PubMed  PubMed Central  Google Scholar 

Tamiz, A. P., Koroshetz, W. J., Dhruv, N. T. & Jett, D. A. A focus on the neural exposome. Neuron 110, 1286–1289 (2022).

Article  CAS  PubMed  Google Scholar 

George, G. C. et al. The Neighborhoods Study: examining the social exposome in Alzheimer’s disease and related dementias. Alzheimers Dement. 21, e70810 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Ibanez, A. & Zimmer, E. R. Time to synergize mental health with brain health. Nat. Ment. Health 1, 441–443 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Genon, S., Eickhoff, S. B. & Kharabian, S. Linking interindividual variability in brain structure to behaviour. Nat. Rev. Neurosci. 23, 307–318 (2022).

Article  CAS  PubMed  Google Scholar 

Hariri, A. R. The neurobiology of individual differences in complex behavioral traits. Annu. Rev. Neurosci. 32, 225–247 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Modabbernia, A., Janiri, D., Doucet, G. E., Reichenberg, A. & Frangou, S. Multivariate patterns of brain-behavior-environment associations in the adolescent brain and cognitive development study. Biol. Psychiatry 89, 510–520 (2021).

Article  PubMed  Google Scholar 

Visoki, E. et al. Classification of suicide attempt risk using environmental and lifestyle factors in 3 large youth cohorts. JAMA Psychiatry 81, 1020–1029 (2024).

Article  PubMed  PubMed Central  Google Scholar