Al-Worafi YM (2023) Liver diseases management in developing countries. In: Al-Worafi YM (ed) Handbook of medical and health sciences in developing countries: Education, Practice, and research. Springer International Publishing, Cham, pp 1–42

Alhusaini A, Fadda L, Hasan IH (2019) Curcumin ameliorates lead-induced hepatotoxicity by suppressing oxidative stress and inflammation, and modulating Akt/GSK-3β signaling pathway. Biomolecules. https://doi.org/10.3390/biom9110703

Article  PubMed  PubMed Central  Google Scholar 

Aninat C, Piton A, Glaise D et al (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75–83. https://doi.org/10.1124/dmd.105.006759

Article  CAS  PubMed  Google Scholar 

Arangia A, Marino Y, Fusco R (2023) Fisetin, a natural polyphenol, ameliorates endometriosis modulating mast cells derived NLRP-3 inflammasome pathway and oxidative stress. Int J Mol Sci. https://doi.org/10.3390/ijms24065076

Article  PubMed  PubMed Central  Google Scholar 

Brattin WJ, Glende EAJ, Recknagel RO (1985) Pathological mechanisms in carbon tetrachloride hepatotoxicity. J Free Radic Biol Med 1:27–38. https://doi.org/10.1016/0748-5514(85)90026-1

Article  CAS  PubMed  Google Scholar 

Chen T-H, Wang H-C, Chang C-J, Lee S-Y (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci. https://doi.org/10.3390/ijms25021314

Article  PubMed  PubMed Central  Google Scholar 

Cheng J, Yan G, Tan W et al (2024) Berberine alleviates fructose-induced hepatic injury via ADK/AMPK/Nrf2 pathway: A novel insight. Biomed Pharmacother 179:117361. https://doi.org/10.1016/j.biopha.2024.117361

Article  CAS  PubMed  Google Scholar 

Cichoż-Lach H, Michalak A (2014) Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol 20:8082–8091. https://doi.org/10.3748/wjg.v20.i25.8082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devarbhavi H, Asrani SK, Arab JP (2023) Global burden of liver disease: 2023 update. J Hepatol 79:516–537. https://doi.org/10.1016/j.jhep.2023.03.017

Article  PubMed  Google Scholar 

Flynn JM, Melov S (2013) SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med 62:4–12. https://doi.org/10.1016/j.freeradbiomed.2013.05.027

Article  CAS  PubMed  Google Scholar 

GÁBOR M, EPERJESSY E (1966) Antibacterial effect of Fisetin and Fisetinidin. Nature 212:1273. https://doi.org/10.1038/2121273a0

Article  PubMed  Google Scholar 

Glancy B, Kane DA, Kavazis AN et al (2021) Mitochondrial lactate metabolism: history and implications for exercise and disease. J Physiol 599:863–888. https://doi.org/10.1113/JP278930

Article  CAS  PubMed  Google Scholar 

Guillouzo A, Corlu A, Aninat C et al (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66–73. https://doi.org/10.1016/j.cbi.2006.12.003

Article  CAS  PubMed  Google Scholar 

Gutmann M, Stimpfl E, Langmann G et al (2023) Differentiated and non-differentiated HepaRG™ cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens. Toxicol Lett 390:15–24. https://doi.org/10.1016/j.toxlet.2023.10.014

Article  CAS  PubMed  Google Scholar 

Hamid ME, Alamri F, Abdelrahim IM et al (2024) Effects of antimicrobial flavonoids against representative bacteria and fungi: a review of the literature. Cureus 16:e62765. https://doi.org/10.7759/cureus.62765

Article  PubMed  PubMed Central  Google Scholar 

Idle JR, Gonzalez FJ (2007) Metabolomics. Cell Metab 6:348–351. https://doi.org/10.1016/J.CMET.2007.10.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jakobson CM, Jarosz DF (2021) Metabolites control stress granule disassembly. Nat Cell Biol 23(10):1053–1055. https://doi.org/10.1038/s41556-021-00768-w

Article  CAS  PubMed  Google Scholar 

Kang KA, Piao MJ, Kim KC et al (2014) Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system. In Vitro Cell Dev Biol 50:66–74. https://doi.org/10.1007/s11626-013-9681-6

Article  CAS  Google Scholar 

Kashyap D, Garg VK, Tuli HS et al (2019) Fisetin and quercetin: promising flavonoids with chemopreventive potential. Biomolecules 9. https://doi.org/10.3390/biom9050174

Khan N, Syed DN, Ahmad N, Mukhtar H (2013) Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal 19:151–162. https://doi.org/10.1089/ars.2012.4901

Article  CAS  PubMed  PubMed Central  Google Scholar 

King A, Selak MA, Gottlieb E (2006) Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 25(34):4675–4682. https://doi.org/10.1038/sj.onc.1209594

Article  CAS  PubMed  Google Scholar 

Koklesova L, Liskova A, Samec M (2021) Protective effects of flavonoids against mitochondriopathies and associated pathologies: focus on the predictive approach and personalized prevention. Int J Mol Sci. https://doi.org/10.3390/ijms22168649

Article  PubMed  PubMed Central  Google Scholar 

Lee S, Hu L (2020) Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction. Med Chem Res Int J Rapid Commun Des Mech Action Biol Act Agents 29:846–867. https://doi.org/10.1007/s00044-020-02539-y

Article  CAS  Google Scholar 

Lee G-H, Bhandary B, Lee E-M et al (2011) The roles of ER stress and P450 2E1 in CCl4-induced steatosis. Int J Biochem Cell Biol 43:1469–1482. https://doi.org/10.1016/j.biocel.2011.06.010

Article  CAS  PubMed  Google Scholar 

Li L, Ji K, Du F et al (2023) Does flavonoid supplementation alleviate Non-Alcoholic fatty liver disease? A systematic review and Meta-Analysis of randomized controlled trials. Mol Nutr Food Res 67:e2300480. https://doi.org/10.1002/mnfr.202300480

Article  CAS  PubMed  Google Scholar 

Liu H, Wang Y, Huang J et al (2024) Analysis on patents of health care products with substances of medicine food homology in China. Chinese Herbal Medicines 16:412–421. https://doi.org/10.1016/j.chmed.2024.03.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Yang J, Hu M et al (2023) Effects of choline deficiency and supplementation on lipid droplet accumulation in bovine primary liver cells in vitro. J Dairy Sci 106:9868–9878. https://doi.org/10.3168/jds.2023-23452

Article  CAS  PubMed  Google Scholar 

Manibusan MK, Odin M, Eastmond DA (2007) Postulated carbon tetrachloride mode of action: a review. J Environ Sci Heal Part C Environ Carcinog Ecotoxicol Rev 25:185–209. https://doi.org/10.1080/10590500701569398

Article  CAS  Google Scholar 

McMillian MK, Grant ER, Zhong Z (2001) Nile red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis. In Vitro & Molecular Toxicology 14:177–190. https://doi.org/10.1089/109793301753407948

Article  CAS  Google Scholar 

Middleton EJ, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751

Article  CAS  PubMed  Google Scholar 

Molagoda IMN, Athapaththu AMGK, Choi YH et al (2021) Fisetin inhibits NLRP3 inflammasome by suppressing TLR4/MD2-mediated mitochondrial ROS production. Antioxidants. https://doi.org/10.3390/antiox10081215

Article