‘Coenzyme Q (2012) 10.’ in LiverTox: clinical and research information on Drug-Induced liver injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD))

Abd El-Salam MA, Smith CEP, Pan CX (2022) Insights on recent innovations in bladder cancer immunotherapy. Cancer Cytopathol 130:667–683

Article  CAS  PubMed  Google Scholar 

Alimohammadi M, Rahimi A, Faramarzi F, Golpour M, Jafari-Shakib R, Alizadeh-Navaei R, Rafiei A (2021) Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials. Inflammopharmacology 29:579–593

Article  CAS  PubMed  Google Scholar 

Arenas-Jal M, Suñé-Negre JM, García-Montoya E (2020) Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf 19:574–594

Article  CAS  PubMed  Google Scholar 

Baird L, Yamamoto M (2020) The molecular mechanisms regulating the KEAP1-NRF2 pathway. Mol Cell Biol, 40

Banek S, Hoeh B, Cano Garcia C, Koll F, Köllermann J, Chun FKH, Wenzel M (2024) Metastatic squamous cell carcinoma of the urinary bladder: urgent call for new therapies. Urol Int 108:1–8

Article  CAS  PubMed  Google Scholar 

Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J (2021) Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind. Placebo-Controlled Trial, Nutrients, p 13

Google Scholar 

Claps F, Pavan N, Ongaro L, Tierno D, Grassi G, Trombetta C, Scaggiante B (2023) BCG-Unresponsive Non-Muscle-Invasive bladder cancer: current treatment landscape and novel emerging molecular targets. Int J Mol Sci, 24

Cui L, Zhou Q, Zheng X, Sun B, Zhao S (2020) Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway. Free Radic Biol Med 161:23–31

Article  CAS  PubMed  Google Scholar 

Dadali T, Diers AR, Kazerounian S, Muthuswamy SK, Awate P, Ng R, Sarangarajan R (2021) Elevated levels of mitochondrial CoQ(10) induce ROS-mediated apoptosis in pancreatic cancer. Sci Rep 11:5749

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobruch J, Oszczudłowski M (2021) Bladder Cancer: Current Challenges and Future Directions, Medicina (Kaunas), 57

Fladerer JP, Grollitsch S (2023) Comparison of coenzyme Q10 (Ubiquinone) and reduced coenzyme Q10 (Ubiquinol) as supplement to prevent cardiovascular disease and reduce cardiovascular mortality. Curr Cardiol Rep 25:1759–1767

Article  PubMed  PubMed Central  Google Scholar 

Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, Sanchez-Alcazar JA (2014) Clinical applications of coenzyme Q10. Front Biosci (Landmark Ed) 19:619–633

Article  CAS  PubMed  Google Scholar 

Hamid A, Syadza YZ, Yausep OE, Christanto RBI, Muharia BHR, Mochtar CA (2023) The expression of stem cells markers and its effects on the propensity for recurrence and metastasis in bladder cancer: A systematic review. PLoS ONE 18:e0269214

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hargreaves I, Heaton RA, Mantle D (2020) Disorders of human coenzyme Q10 metabolism: an overview. Int J Mol Sci, 21

Hargreaves IP (2014) Coenzyme Q10 as a therapy for mitochondrial disease. Int J Biochem Cell Biol 49:105–111

Article  CAS  PubMed  Google Scholar 

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Gan B (2022) A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun 13:2206

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SQ, Tan TS, Kawamukai M, Chen ES (2017) Cellular factories for coenzyme Q(10) production. Microb Cell Fact 16:39

Article  PubMed  PubMed Central  Google Scholar 

Li T, Jiang D, Wu K (2020) p62 promotes bladder cancer cell growth by activating KEAP1/NRF2-dependent antioxidative response. Cancer Sci 111:1156–1164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Xue WJ (2020) BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res 39:123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Pi J, Zhang Q (2022) Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway. Redox Biol 54:102389

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L (2024) Advances in diagnosis and treatment of bladder cancer. BMJ 384:e076743

Article  CAS  PubMed  Google Scholar 

Lu YY, Zhu CY, Ding YX, Wang B, Zhao SF, Lv J, Qi WW (2023) Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway. Cell Death Discov 9:450

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mantle D, Hargreaves IP (2024) Coenzyme Q10 and autoimmune disorders: an overview. Int J Mol Sci, 25

Miedziaszczyk M, Cieślewicz A, Jabłecka A (2021) Efficacy of coenzyme Q10 in supportive therapy of the cardiovascular diseases and in the prevention of cardiotoxicity caused by chemotherapy. Pol Merkur Lekarski 49:158–161

PubMed  Google Scholar 

Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. Int J Mol Sci, 23

Pfail JL, Small AC, Cumarasamy S, Galsky MD (2021) Real world outcomes of patients with bladder cancer: effectiveness versus efficacy of modern treatment paradigms. Hematol Oncol Clin North Am 35:597–612

Article  PubMed  Google Scholar 

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Bitto A (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763

Article  PubMed  PubMed Central  Google Scholar 

Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ (2018) Effects of coenzyme Q10 on Statin-Induced myopathy: an updated Meta-Analysis of randomized controlled trials. J Am Heart Assoc 7:e009835

Article  PubMed  PubMed Central  Google Scholar 

Rauchová H (2021) Coenzyme Q10 effects in neurological diseases. Physiol Res 70:S683–s714

Article  PubMed  PubMed Central  Google Scholar 

Shidal C, Yoon HS, Zheng W, Wu J, Franke AA, Blot WJ, Cai Q (2021) Prospective study of plasma levels of coenzyme Q10 and lung cancer risk in a low-income population in the southeastern united States. Cancer Med 10:1439–1447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sue-Ling CB, Abel WM, Sue-Ling K (2022) Coenzyme Q10 as adjunctive therapy for cardiovascular disease and hypertension: A systematic review. J Nutr 152:1666–1674

Article  PubMed  Google Scholar 

Sundararaghavan VL, Sindhwani P, Hinds TD Jr (2017) Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas? Oncotarget 8:3640–3648

Article  PubMed  PubMed Central  Google Scholar 

Tafazoli A (2017) Coenzyme Q10 in breast cancer care. Future Oncol 13:1035–1041

Article  CAS  PubMed  Google Scholar 

Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D (2021) Advances in bladder cancer biology and therapy. Nat Rev Cancer 21:104–121

Article  CAS  PubMed  Google Scholar 

Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Hwang TI (2020) Miconazole contributes to NRF2 activation by noncanonical P62-KEAP1 pathway in bladder cancer cells. Drug Des Devel Ther 14:1209–1218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang B, Wang Y, Zhang J, Hu C, Jiang J, Li Y, Peng Z (2023) ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Arch Toxicol 97:1439–1451

Article  CAS