Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via based on transcriptome sequencing analysis

Ajoolabady A, Pratico D, Bahijri S, Eldakhakhny B, Tuomilehto J, Wu F, Ren J (2025) Hallmarks and mechanisms of cellular senescence in aging and disease. Cell Death Discov 11:364

Article  PubMed  PubMed Central  Google Scholar 

Cai L, Chen J, Yuan Q, Zhuang W, Wang G, Xu X, Yao Y, Hu WW (2025) Recent advances in platelet-rich plasma therapy for osteoarthritis: mechanisms and clinical efficacy. J Mater Chem B 13:9001–9022

Article  CAS  PubMed  Google Scholar 

Clough E, Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM et al (2024) NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update. Nucleic Acids Res 52:D138–d144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crowley JL, Soti V (2023) Platelet-Rich Plasma Therapy: An Effective Approach for Managing Knee Osteoarthritis. Cureus 15:e50774

PubMed  PubMed Central  Google Scholar 

da Costa BR, Reichenbach S, Keller N, Nartey L, Wandel S, Jüni P, Trelle S (2017) Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 390:e21–e33

Article  PubMed  Google Scholar 

Damerau A, Rosenow E, Alkhoury D, Buttgereit F, Gaber T (2024) Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis. Front Immunol 15:1385006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dos Santos RG, Santos GS, Alkass N, Chiesa TL, Azzini GO, da Fonseca LF, Dos Santos AF, Rodrigues BL, Mosaner T, Lana JF (2021) The regenerative mechanisms of platelet-rich plasma: A review. Cytokine 144:155560

Article  CAS  PubMed  Google Scholar 

Engeland K (2022) Cell cycle regulation: p53-p21-RB signaling. Cell Death Differ 29:946–960

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finnson KW, Chi Y, Bou-Gharios G, Leask A, Philip A (2012) TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed) 4:251–268

Article  PubMed  Google Scholar 

Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C (2023) Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci 24:6405

He Y, Zhu W, Alexander PG, Hines SE, Bartholomew OG, Zhao C, Liu Q, Lin H (2025) Forkhead box O proteins in chondrocyte aging and diseases. J Orthop Translat 54:167–179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang S, Li X (2024) UBE2C promotes LUAD progression by ubiquitin-dependent degradation of p53 to inactivate the p53/p21 signaling pathway. Discov Oncol 15:589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Isaji Y, Kurasawa Y, Sasaki D, Hayashi M, Kitagawa T (2025) Psychological intervention for knee osteoarthritis: a systematic review and meta-analysis. Psychol Health Med 30:636–662

Article  PubMed  Google Scholar 

Jiang W, Chen H, Lin Y, Cheng K, Zhou D, Chen R, Song C, Zeng L, Yu H (2023) Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritis. Biomed Pharmacother 167:115552

Article  CAS  PubMed  Google Scholar 

Kukurba KR, Montgomery SB (2015) RNA Sequencing and Analysis. Cold Spring Harb Protoc 2015:951–969

Article  PubMed  PubMed Central  Google Scholar 

Li M, Xia Q, Nie Q, Ding L, Huang Z, Jiang Z (2025) Burden of knee osteoarthritis in China and globally: 1990–2045. BMC Musculoskelet Disord 26:582

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Luo P, Yang M, Wang J, Hou W, Xu P (2022) The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Front Mol Biosci 9:1001212

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Sun Y, Pan J, Guo K, Tang Z, Wang X (2024) Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis. Front Endocrinol (Lausanne) 15:1479909

Article  PubMed  PubMed Central  Google Scholar 

Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A (2020) Role of p53 in the Regulation of Cellular Senescence. Biomolecules 10

Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG (2024) ROS production by mitochondria: function or dysfunction? Oncogene 43:295–303

Article  CAS  PubMed  Google Scholar 

Salis Z, Sainsbury A (2024) Association of long-term use of non-steroidal anti-inflammatory drugs with knee osteoarthritis: a prospective multi-cohort study over 4-to-5 years. Sci Rep 14:6593

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M (2022) Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol 18:258–275

Article  PubMed  PubMed Central  Google Scholar 

Shetty S, Maiya GA, Rao Kg M, Vijayan S, George BM (2024) Factors determinant of quality of life after total knee arthroplasty in knee osteoarthritis: A systematic review. J Bodyw Mov Ther 40:1588–1604

Article  PubMed  Google Scholar 

Siddiq MAB, Clegg D, Jansen TL, Rasker JJ (2022) Emerging and New Treatment Options for Knee Osteoarthritis. Curr Rheumatol Rev 18:20–32

Article  CAS  PubMed  Google Scholar 

Suh DK, Yeo WJ, Cheong K, Heo JW, Kim DH, Lee SM, Lee YS, Suh DW (2024) Transcriptome Analysis of Platelet-Rich Plasma-Treated Osteoarthritic Chondrocyte. Biomed Res Int 2024:7680736

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tampere T, Arnout N, Victor J (2025) Total knee arthroplasty: The need for better patient selection. Knee Surg Sports Traumatol Arthrosc 33:784–788

Article  CAS  PubMed  Google Scholar 

Vun J, Iqbal N, Jones E, Ganguly P (2023) Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging. Bioeng (Basel) 10

Wang A, Wu J, Yang S (2025) Integrating the summary data-based mendelian randomization and transcriptomic analysis identifies candidate genes and repositioning targets for asthma. Curr Proteomics 22:100019

Article  Google Scholar 

Wang S, Huo T, Lu M, Zhao Y, Zhang J, He W, Chen H (2025) Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies. Cells 14

Wang YH, Song H, Yu WQ (2025) [Mechanism of regulating PI3K-Akt signaling pathway and inhibiting chondrocyte apoptosis to improve inflammation levels in rats with knee osteoarthritis by Shenzhuo Decoction]. Zhongguo Zhong Yao Za Zhi 50:3389–3398

CAS  PubMed  Google Scholar 

Wei Q, Zhu X, Wang L, Zhang W, Yang X, Wei W (2023) Extracellular matrix in synovium development, homeostasis and arthritis disease. Int Immunopharmacol 121:110453

Article  CAS  PubMed  Google Scholar 

Wu J, Zhu X (2025) Glucosamine hinders IL-1β-induced CHON-001 cell injury and inflammation by inhibiting YY1-mediated TLR8. Lett Drug Des Discovery 22:100003

Article  Google Scholar 

Xu X, Pang Y, Fan X (2025) Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances. Signal Transduct Target Ther 10:190

Article  PubMed  PubMed Central  Google Scholar 

Zahir H, Dehghani B, Yuan X, Chinenov Y, Kim C, Burge A, Bandhari R, Nemirov D, Fava P, Moley P et al (2021) In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis. Sci Rep 11:11493

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang JY, Xiang XN, Wang Q, Wang XX, Guan AJ, He CQ, Yu X, He HC (2025) The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis. Am J Sports Med 53:1428–1439

Article 

Comments (0)

No login
gif