Stevens MS (2015) Restless Legs Syndrome/Willis-Ekbom Disease Morbidity: Burden, Quality of Life, Cardiovascular Aspects, and Sleep. Sleep Med Clin 10, 369–373, xv-xvi. https://doi.org/10.1016/j.jsmc.2015.05.017
Khan M (2023) Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders. Continuum (Minneapolis Minn) 1:1130–1148. https://doi.org/10.1212/CON.0000000000001269
Connor JR, Patton S, Oexle K, Allen R (2016) Iron and restless legs syndrome: Treatment, genetics and pathophysiology. Sleep Med 31:61–70. https://doi.org/10.1016/j.sleep.2016.07.028
Article PubMed PubMed Central Google Scholar
Winkelman JW et al (2025) Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med 21:137–152. https://doi.org/10.5664/jcsm.11390
Article PubMed PubMed Central Google Scholar
Silver N, Allen RP, Senerth J, Earley CJ (2011) A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome. Sleep Med 12:440–444
Best C, Sayegh ALC, Janzen A, Oertel WH, Kramer H (2025) H. RLS shows increased resting state sympathetic activity and decreased sympathetic response capability. J Neurol 272:545. https://doi.org/10.1007/s00415-025-13285-9
Article CAS PubMed PubMed Central Google Scholar
Guo S et al (2017) Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. Front Aging Neurosci 9:171. https://doi.org/10.3389/fnagi.2017.00171
Article CAS PubMed PubMed Central Google Scholar
Gossard TR, Trotti LM, Videnovic A, St Louis EK (2021) Restless Legs Syndrome: Contemporary Diagnosis and Treatment. Neurotherapeutics 18:140–155. https://doi.org/10.1007/s13311-021-01019-4
Article CAS PubMed PubMed Central Google Scholar
Abdulhadi IG, Al-Mahdawi AM, Hamdan FB (2021) Electrophysiological findings in patients with restless legs syndrome. Sleep Med 87:151–157. https://doi.org/10.1016/j.sleep.2021.09.012
Turkoglu SA, Bolac ES, Yildiz S, Kalaycioglu O (2021) Yildiz, N. Presynaptic inhibition in restless legs syndrome. Int J Neurosci 131:213–219. https://doi.org/10.1080/00207454.2020.1737048
Lin Y et al (2018) Impaired Sensorimotor Integration in Restless Legs Syndrome. Front Neurol 9:568. https://doi.org/10.3389/fneur.2018.00568
Article PubMed PubMed Central Google Scholar
Marconi S et al (2012) Group I nonreciprocal inhibition in restless legs syndrome secondary to chronic renal failure. Parkinsonism Relat Disord 18:362–366. https://doi.org/10.1016/j.parkreldis.2011.12.002
Zhao LQ, Wang LN, Hu FY (2010) [The clinical research of restless leg syndrome and Parkinson’s disease]. Zhonghua nei ke za zhi 49:947–950
Scaglione C et al (2008) Group I nonreciprocal inhibition in primary restless legs syndrome. Mov Disord 23:96–100. https://doi.org/10.1002/mds.21794
Paulus W et al (2007) Pathophysiological concepts of restless legs syndrome. Mov Disord 22:1451–1456. https://doi.org/10.1002/mds.21533
Rijsman RM, Stam CJ, de Weerd AW (2005) Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder. Clin Neurophysiol 116:204–210. https://doi.org/10.1016/j.clinph.2004.07.022
Article CAS PubMed Google Scholar
Dafkin C, McKinon W, Kerr S (2019) Restless legs syndrome: Clinical changes in nervous system excitability at the spinal cord level. Sleep Med Rev 47:9–17. https://doi.org/10.1016/j.smrv.2019.05.005
Woods S, Basco J, Clemens S (2023) Effects of iron-deficient diet on sleep onset and spinal reflexes in a rodent model of Restless Legs Syndrome. Front Neurol 14:1160028. https://doi.org/10.3389/fneur.2023.1160028
Article PubMed PubMed Central Google Scholar
Lanza G et al (2024) Targeting the adenosinergic system in restless legs syndrome: A pilot, proof-of-concept placebo-controlled TMS-based protocol. PLoS ONE 19:e0302829. https://doi.org/10.1371/journal.pone.0302829
Article CAS PubMed PubMed Central Google Scholar
Lanza G et al (2017) Central and peripheral nervous system excitability in restless legs syndrome. Sleep Med 31:49–60. https://doi.org/10.1016/j.sleep.2016.05.010
Lanza G, Mogavero MP, Ferri R, Pani T (2025) Motor cortex excitability in restless legs syndrome: A systematic review and insights into pathophysiology via transcranial magnetic stimulation. Sleep Med Rev 79:102027. https://doi.org/10.1016/j.smrv.2024.102027
Nardone R et al (2020) Contribution of transcranial magnetic stimulation in restless legs syndrome: pathophysiological insights and therapeutical approaches. Sleep Med 71:124–134. https://doi.org/10.1016/j.sleep.2019.12.009
Ferreri F, Rossini PM (2004) Neurophysiological investigations in restless legs syndrome and other disorders of movement during sleep. Sleep Med 5:397–399. https://doi.org/10.1016/j.sleep.2004.01.010
Article CAS PubMed Google Scholar
Jeon Y, Huh BK (2009) Spinal cord stimulation for chronic pain. Ann Acad Med Singap 38:998–1003
Tergau F, Wischer S, Paulus W (1999) Motor system excitability in patients with restless legs syndrome. Neurology 52:1060–1063. https://doi.org/10.1212/wnl.52.5.1060
Article CAS PubMed Google Scholar
Pagani-Estévez GL et al (2023) Potential therapeutic benefit of spinal cord stimulation in restless legs syndrome: scoping review and mechanistic considerations. Pain Med 24:S18–s23. https://doi.org/10.1093/pm/pnad089
Walters AS et al (2003) Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4:121–132. https://doi.org/10.1016/s1389-9457(02)00258-7
Bogan RK et al (2023) Efficacy and safety of tonic motor activation (TOMAC) for medication-refractory restless legs syndrome: a randomized clinical trial. Sleep 46. https://doi.org/10.1093/sleep/zsad190
Buchfuhrer MJ et al (2021) Noninvasive neuromodulation reduces symptoms of restless legs syndrome. J Clin Sleep Med 17:1685–1694. https://doi.org/10.5664/jcsm.9404
Article PubMed PubMed Central Google Scholar
Buchfuhrer MJ, Roy A, Rodriguez S, Charlesworth JD (2023) Adjunctive tonic motor activation enables opioid reduction for refractory restless legs syndrome: a prospective, open-label, single-arm clinical trial. BMC Neurol 23:415. https://doi.org/10.1186/s12883-023-03462-6
Article CAS PubMed PubMed Central Google Scholar
Roy A et al (2023) Long-term efficacy and safety of tonic motor activation for treatment of medication-refractory restless legs syndrome: A 24-Week Open-Label Extension Study. Sleep 46. https://doi.org/10.1093/sleep/zsad188
Singh H et al (2024) Efficacy and safety of TOMAC for treatment of medication-naïve and medication-refractory restless legs syndrome: A randomized clinical trial and meta-analysis. Sleep Med 122:141–148. https://doi.org/10.1016/j.sleep.2024.08.017
Article PubMed PubMed Central Google Scholar
Holland MT et al (2016) Epidural Spinal Cord Stimulation: A Novel Therapy in the Treatment of Restless Legs Syndrome. World Neurosurg 92 582.e515-582.e518. https://doi.org/10.1016/j.wneu.2016.05.077
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